Fertility and Sterility
Volume 93, Issue 2 , Pages 442-446 , 15 January 2010

Serum estradiol levels during controlled ovarian hyperstimulation influence the pregnancy outcome of in vitro fertilization in a concentration-dependent manner

  • Bo Sun Joo, Ph.D.

      Affiliations

    • Center for Reproductive Medicine, Good Moonhwa Hospital, Busan, South Korea
    • ,
  • Sea Hee Park, M.S.

      Affiliations

    • Center for Reproductive Medicine, Good Moonhwa Hospital, Busan, South Korea
    • ,
  • Byeong Min An, M.S.

      Affiliations

    • Center for Reproductive Medicine, Good Moonhwa Hospital, Busan, South Korea
    • ,
  • Kyung Sue Kim, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Good Moonhwa Hospital, Busan, South Korea
    • ,
  • Sung Eun Moon, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Good Moonhwa Hospital, Busan, South Korea
    • ,
  • Hwa Sook Moon, M.D., Ph.D.

      Affiliations

    • Center for Reproductive Medicine, Good Moonhwa Hospital, Busan, South Korea
    • Department of Obstetrics and Gynecology, Good Moonhwa Hospital, Busan, South Korea
    • Corresponding Author InformationReprint requests: Hwa Sook Moon, M.D., Ph.D., Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Good Moonhwa Hospital, 899-8 Bum-il Dong, Busan, 601-062, South, Korea (FAX: 82-51-630-0750).

Received 1 November 2008 ,Revised 20 February 2009 ,Accepted 23 February 2009.

References 

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  2. Navot D, Laufer N, Kopolovic J, Rabinowitz R, Birkenfeld A, Lewin A, et al. Artificially induced endometrial cycles and establishment of pregnancies in the absence of ovaries. N Engl J Med. 1986;314:806–811
  3. Li TC, Cooke ID, Warren MA, Goolamallee M, Graham RA, Aplin JD. Endometrial responses in artificial cycles: a prospective study comparing four different oestrogen dosages. Br J Obstet Gynaecol. 1992;99:751–756
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  8. Yang JH, Wu MY, Chen CD, Jiang MC, Ho HN, Yang YS. Association of endometrial blood flow as determined by a modified colour Doppler technique with subsequent outcome of in-vitro fertilization. Hum Reprod. 1999;14:1606–1610
  9. Schmidt CL, de Ziegler D, Gagliardi CL, Mellon RW, Taney FH, Kuhar MJ, et al. Transfer of cryopreserved-thawed embryos: the natural cycle versus controlled preparation of the endometrium with gonadotropin-releasing hormone agonist and exogenous estradiol and progesterone (GEEP). Fertil Steril. 1989;52:609–616
  10. Farhi J, Weissman A, Steinfeld Z, Shorer M, Nahum H, Levran D. Estradiol supplementation during the luteal phase may improve the pregnancy rate in patients undergoing in vitro fertilization–embryo transfer cycles. Fertil Steril. 2000;73:761–766
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  14. Yu Ng EH, Yeung WS, Yee Lan Lau E, So WW, Ho PC. High serum oestradiol concentrations in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent frozen-thawed embryo transfer cycles. Hum Reprod. 2000;15:250–255
  15. Levi AJ, Drews MR, Bergh PA, Miller BT, Scott RT. Controlled ovarian hyperstimulation does not adversely affect endometrial receptivity in in vitro fertilization cycles. Fertil Steril. 2001;76:670–674
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  17. Testart J, Belaisch-Allart J, Forman R, Gazengel A, Strubb N, Hazout A, et al. Influence of different stimulation treatments on oocyte characteristics and in-vitro fertilizing ability. Hum Reprod. 1989;4:92–97
  18. Kosmas IP, Kolibianakis EM, Devroey P. Association of estradiol levels on the day of hCG administration and pregnancy achievement in IVF: a systematic review. Hum Reprod. 2004;19:2446–2453
  19. Serna J, Cholquevilque JL, Cela V, Martinez-Salazar J, Requena A, Garcia-Velasco JA. Estradiol supplementation during the luteal phase of IVF-ICSI patients: a randomized, controlled trial. Fertil Steril. 2008;90:2190–2195
  20. Blazar AS, Hogan JW, Frankfurter D, Hackett R, Keefe DL. Serum estradiol positively predicts outcomes in patients undergoing in vitro fertilization. Fertil Steril. 2004;81:1707–1709
  21. van der Gaast MH, Eijkemans MJ, van der Net JB, de Boer EJ, Burger CW, van Leeuwen FE, et al. Optimum number of oocytes for a successful first IVF treatment cycle. Reprod Biomed Online. 2006;13:476–480
  22. Mitwally MF, Bhakoo HS, Crickard K, Sullivan MW, Batt RE, Yeh J. Estradiol production during controlled ovarian hyperstimulation correlates with treatment outcome in women undergoing in vitro fertilization-embryo transfer. Fertil Steril. 2006;86:588–596
  23. Valbuena D, Martin J, de Pablo JL, Remohi J, Pellicer A, Simon C. Increasing levels of estradiol are deleterious to embryonic implantation because they directly affect the embryo. Fertil Steril. 2001;76:962–968
  24. Friedler S, Zimerman A, Schachter M, Raziel A, Strassburger D, Ron El R. The midluteal decline in serum estradiol levels is drastic but not deleterious for implantation after in vitro fertilization and embryo transfer in patients with normal or high responses. Fertil Steril. 2005;83:54–60
  25. Fanchin R, Righini C, de Ziegler D, Olivennes F, Ledee N, Frydman R. Effects of vaginal progesterone administration on uterine contractility at the time of embryo transfer. Fertil Steril. 2001;75:1136–1140
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  27. DiLuigi AJ, Nulsen JC. Effects of gonadotropin-releasing hormone agonists and antagonists on luteal function. Curr Opin Obestet Gynecol. 2007;19:258–265

 B.S.J. has nothing to disclose. S.H.P. has nothing to disclose. B.M.A. has nothing to disclose. K.S.K. has nothing to disclose. S.E.M. has nothing to disclose. H.S.M. has nothing to disclose.

PII: S0015-0282(09)00493-2

doi: 10.1016/j.fertnstert.2009.02.066

Fertility and Sterility
Volume 93, Issue 2 , Pages 442-446 , 15 January 2010

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