Resumption of ovarian function 20 years after chemotherapy-induced ovarian failure: a case report
Received 26 September 2008 ; received in revised form 24 February 2009 ; accepted 25 February 2009 . published online 28 April 2009.
Objective To describe a case of resumption of ovarian function 20 years after chemotherapy-induced ovarian failure.
Setting University teaching hospital.
Patient(s) A 33-year-old nulliparous black woman.
Intervention(s) Progesterone challenge, transvaginal ultrasound (TVS).
Main Outcome Measure(s) Estradiol and FSH hormone levels.
Result(s) Confirmation that ovarian function returned in a women who presented with cyclic vaginal bleeding after a 20-year history of amenorrhea secondary to chemotherapy-induced ovarian failure.
Conclusion(s) Return of ovarian function is possible after prolonged periods in women with chemotherapy-induced ovarian failure.
a School of Medicine, Virginia Commonwealth University Medical Center, Richmond Virginia
b Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia
Reprint requests: Catherine A. Matthews, M.D., 1250 E. Marshall Street, Box 980034, Richmond, VA 23298 (FAX: 804-828-3891).
M.L. has nothing to disclose. C.A.M. has nothing to disclose.
PII: S0015-0282(09)00509-3
doi:10.1016/j.fertnstert.2009.02.082
© 2009 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
ABSTRACT