Fertility and Sterility
Volume 92, Issue 1 , Pages 392.e17-392.e18, July 2009

Resumption of ovarian function 20 years after chemotherapy-induced ovarian failure: a case report

  • Megin Longway, B.A.

      Affiliations

    • School of Medicine, Virginia Commonwealth University Medical Center, Richmond Virginia
    • ,
  • Catherine A. Matthews, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, Virginia
    • Corresponding Author InformationReprint requests: Catherine A. Matthews, M.D., 1250 E. Marshall Street, Box 980034, Richmond, VA 23298 (FAX: 804-828-3891).

Received 26 September 2008; received in revised form 24 February 2009; accepted 25 February 2009. published online 28 April 2009.

Objective

To describe a case of resumption of ovarian function 20 years after chemotherapy-induced ovarian failure.

Design

Case report.

Setting

University teaching hospital.

Patient(s)

A 33-year-old nulliparous black woman.

Intervention(s)

Progesterone challenge, transvaginal ultrasound (TVS).

Main Outcome Measure(s)

Estradiol and FSH hormone levels.

Result(s)

Confirmation that ovarian function returned in a women who presented with cyclic vaginal bleeding after a 20-year history of amenorrhea secondary to chemotherapy-induced ovarian failure.

Conclusion(s)

Return of ovarian function is possible after prolonged periods in women with chemotherapy-induced ovarian failure.

Key Words: Premature ovarian failure, chemotherapy, acute myeloblastic leukemia, ovarian function

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 M.L. has nothing to disclose. C.A.M. has nothing to disclose.

PII: S0015-0282(09)00509-3

doi:10.1016/j.fertnstert.2009.02.082

Fertility and Sterility
Volume 92, Issue 1 , Pages 392.e17-392.e18, July 2009

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