Fertility and Sterility
Volume 92, Issue 4 , Pages 1344-1346, October 2009

Sperm chromatin anomalies have an adverse effect on the outcome of conventional in vitro fertilization: a study with strictly controlled external factors

  • Long-Jie Gu, Ph.D.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • Graduate School of Peking Union Medical College, Beijing, People's Republic of China
    • ,
  • Zhen-Wen Chen, Ph.D., M.D.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Zhen-Wen Chen, Department of Male Clinical Research, National Research Institute for Family Planning, 12 Dahuisi Road, Haidian District, Beijing, 100081, People's Republic of China (FAX: 86-10-62173650).
    • ,
  • Zi-Jiang Chen, Ph.D., M.D.

      Affiliations

    • Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
    • ,
  • Jian-Feng Xu, M.Med.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • ,
  • Mei Li, M.Med.

      Affiliations

    • Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

Received 16 January 2009; received in revised form 5 March 2009; accepted 6 March 2009. published online 14 April 2009.

Conflicting conclusions present in earlier studies on the relationship between sperm chromatin anomalies and outcome of conventional in vitro fertilization (IVF) may result from confounding by poorly controlled external factors. We examined the relationship of sperm chromatin parameters and outcome of conventional IVF while strictly controlling external factors.

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 L.-J.G. has nothing to disclose. Z.-W.C. has nothing to disclose. Z.-J.C. has nothing to disclose. J.-F.X. has nothing to disclose. M.L. has nothing to disclose.

PII: S0015-0282(09)00596-2

doi:10.1016/j.fertnstert.2009.03.031

Fertility and Sterility
Volume 92, Issue 4 , Pages 1344-1346, October 2009

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