Fertility and Sterility
Volume 92, Issue 4 , Pages 1344-1346 , October 2009

Sperm chromatin anomalies have an adverse effect on the outcome of conventional in vitro fertilization: a study with strictly controlled external factors

  • Long-Jie Gu, Ph.D.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • Graduate School of Peking Union Medical College, Beijing, People's Republic of China
    • ,
  • Zhen-Wen Chen, Ph.D., M.D.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Zhen-Wen Chen, Department of Male Clinical Research, National Research Institute for Family Planning, 12 Dahuisi Road, Haidian District, Beijing, 100081, People's Republic of China (FAX: 86-10-62173650).
    • ,
  • Zi-Jiang Chen, Ph.D., M.D.

      Affiliations

    • Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China
    • ,
  • Jian-Feng Xu, M.Med.

      Affiliations

    • Department of Male Clinical Research, National Research Institute for Family Planning, Beijing, People's Republic of China
    • ,
  • Mei Li, M.Med.

      Affiliations

    • Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, Jinan, People's Republic of China

Received 16 January 2009 ,Revised 5 March 2009 ,Accepted 6 March 2009.

References 

  1. Zini A, Libman J. Sperm DNA damage: importance in the era of assisted reproduction. Curr Opin Urol. 2006;16:428–434
  2. Carrell DT, Liu L, Peterson CM, Jones KP, Hatasaka HH, Erickson L, et al. Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss. Arch Androl. 2003;49:49–55
  3. Bungum M, Humaidan P, Axmon A, Spano M, Bungum L, Erenpreiss J, et al. Sperm DNA integrity assessment in prediction of assisted reproduction technology outcome. Hum Reprod. 2007;22:174–179
  4. Muriel L, Garrido N, Fernandez JL, Remohi J, Pellicer A, de los Santos MJ, et al. Value of the sperm deoxyribonucleic acid fragmentation level, as measured by the sperm chromatin dispersion test, in the outcome of in vitro fertilization and intracytoplasmic sperm injection. Fertil Steril. 2006;85:371–383
  5. Boe-Hansen G, Fedder J, Ersboll AK, Christensen P. The sperm chromatin structure assay as a diagnostic tool in the human fertility clinic. Hum Reprod. 2006;21:1576–1582
  6. Borini A, Tarozzi N, Bizzaro D, Bonu MA, Fava L, Flamigni C, et al. Sperm DNA fragmentation: paternal effect on early post-implantation embryo development in ART. Hum Reprod. 2006;21:2876–2881
  7. Karydis S, Asimakopoulos B, Papadopoulos N, Vakalopoulos I, Al-hasani S, Nikolettos N. ICSI outcome is not associated with the incidence of spermatozoa with abnormal chromatin condensation. In Vivo. 2005;19:921–925
  8. Li Z, Wang L, Cai J, Huang H. Correlation of sperm DNA damage with IVF and ICSI outcomes: a systematic review and meta-analysis. J Assist Reprod Genet. 2006;23:367–376
  9. Gupta S, Goldberg JM, Aziz N, Goldberg E, Krajcir N, Agarwal A. Pathogenic mechanisms in endometriosis-associated infertility. Fertil Steril. 2008;90:247–257
  10. Virro MR, Larson-Cook KL, Evenson DP. Sperm chromatin structure assay (SCSA) parameters are related to fertilization, blastocyst development, and ongoing pregnancy in in vitro fertilization and intracytoplasmic sperm injection cycles. Fertil Steril. 2004;81:1289–1295
  11. Razavi S, Nasr-Esfahani MH, Mardani M, Mafi A, Moghdam A. Effect of human sperm chromatin anomalies on fertilization outcome post-ICSI. Andrologia. 2003;35:238–243
  12. Liu DY, Baker HW. Human sperm bound to the zona pellucida have normal nuclear chromatin as assessed by acridine orange fluorescence. Hum Reprod. 2007;22:1597–1602
  13. Braude P, Bolton V, Moore S. Human gene expression first occurs between the four- and eight-cell stages of preimplantation development. Nature. 1988;332(6163):459–461

 L.-J.G. has nothing to disclose. Z.-W.C. has nothing to disclose. Z.-J.C. has nothing to disclose. J.-F.X. has nothing to disclose. M.L. has nothing to disclose.

PII: S0015-0282(09)00596-2

doi: 10.1016/j.fertnstert.2009.03.031

Fertility and Sterility
Volume 92, Issue 4 , Pages 1344-1346 , October 2009

Article Tools