Fertility and Sterility
Volume 94, Issue 3 , Pages 952-957 , August 2010

Follicular fluid steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection

This work was originally presented and poster awarded 3rd prize at ASRM October 2007 in Washington, DC.

  • Julie D. Lamb, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California
    • ,
  • A. Musa Zamah, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California
    • ,
  • Shehua Shen, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California
    • ,
  • Charles McCulloch, Ph.D.

      Affiliations

    • Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, California
    • ,
  • Marcelle I. Cedars, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California
    • ,
  • Mitchell P. Rosen, M.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California at San Francisco, San Francisco, California
    • Corresponding Author InformationReprint requests: Mitchell P. Rosen, M.D., UCSF Center for Reproductive Health, 2356 Sutter Street, 7th Floor, San Francisco, CA 94115-0916 (FAX: 415-353-7744).

Received 17 September 2008 ,Revised 2 April 2009 ,Accepted 3 April 2009.

References 

  1. Teissier MP, Chable H, Paulhac S, Aubard Y. Comparison of follicle steroidogenesis from normal and polycystic ovaries in women undergoing IVF: relationship between steroid concentrations, follicle size, oocyte quality and fecundability. Hum Reprod. 2000;15:2471–2477
  2. Gougeon A. Regulation of ovarian follicular development in primates: facts and hypotheses. Endocr Rev. 1996;17:121–155
  3. Rosen MP, Zamah AM, Shen S, Dobson AT, McCulloch CE, Rinaudo P, et al. The effect of follicular fluid hormones on oocyte recovery after ovarian stimulation: FSH level predicts oocyte recovery. Reproductive Biology and Endocrinology. 2009;7:35
  4. Andersen CY. Characteristics of human follicular fluid associated with successful conception after in vitro fertilization. J Clin Endocrinol Metab. 1993;77:1227–1234
  5. Fukuda M, Fukuda K, Yding Andersen C, Byskov AG. Healthy and atretic follicles: vaginosonographic detection and follicular fluid hormone profiles. Hum Reprod. 1995;10:1633–1637
  6. Mendoza C, Cremades N, Ruiz-Requena E, Martinez F, Ortega E, Bernabeu S, et al. Relationship between fertilization results after intracytoplasmic sperm injection, and intrafollicular steroid, pituitary hormone and cytokine concentrations. Hum Reprod. 1999;14:628–635
  7. Rosen MP, Shen S, Dobson AT, Rinaudo PF, McCulloch CE, Cedars MI. A quantitative assessment of follicle size on oocyte developmental competence. Fertil Steril. 2008;90:684–690
  8. Reinthaller A, Deutinger J, Riss P, Muller-Tyl E, Fischl F, Bieglmayer C, et al. Relationship between the steroid and prolactin concentration in follicular fluid and the maturation and fertilization of human oocytes. J In Vitro Fert Embryo Transf. 1987;4:228–231
  9. Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N. The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection. Fertil Steril. 2008;90:60–64
  10. Wittmaack FM, Kreger DO, Blasco L, Tureck RW, Mastroianni L, Lessey BA. Effect of follicular size on oocyte retrieval, fertilization, cleavage, and embryo quality in in vitro fertilization cycles: a 6-year data collection. Fertil Steril. 1994;62:1205–1210
  11. Rosen MP, Shen S, Dobson AT, Fujimoto VY, McCulloch CE, Cedars MI. Oocyte degeneration after intracytoplasmic sperm injection: a multivariate analysis to assess its importance as a laboratory or clinical marker. Fertil Steril. 2006;85:1736–1743
  12. Van Blerkom J, Antczak M, Schrader R. The developmental potential of the human oocyte is related to the dissolved oxygen content of follicular fluid: association with vascular endothelial growth factor levels and perifollicular blood flow characteristics. Hum Reprod. 1997;12:1047–1055
  13. Mendoza C, Ruiz-Requena E, Ortega E, Cremades N, Martinez F, Bernabeu R, et al. Follicular fluid markers of oocyte developmental potential. Hum Reprod. 2002;17:1017–1022
  14. Smitz J, Andersen AN, Devroey P, Arce JC. Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients. Hum Reprod. 2007;22:676–687

 J.D.L. has nothing to disclose. A.M.Z. has nothing to disclose. S.S. has nothing to disclose. C.M. has nothing to disclose. M.I.C. has nothing to disclose. M.P.R. has nothing to disclose.

PII: S0015-0282(09)00840-1

doi: 10.1016/j.fertnstert.2009.04.010

Fertility and Sterility
Volume 94, Issue 3 , Pages 952-957 , August 2010

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