Fertility and Sterility
Volume 92, Issue 4 , Pages 1378-1380, October 2009

Ovarian control of pituitary sensitivity of luteinizing hormone secretion to gonadotropin-releasing hormone in women with the polycystic ovary syndrome

  • Konstantinos Dafopoulos, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Christos Venetis, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Spyros Pournaras, M.D.

      Affiliations

    • Department of Microbiology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Athanasios Kallitsaris, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Ioannis E. Messinis, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • Corresponding Author InformationReprint requests: Ioannis E. Messinis, M.D., Ph.D., Department of Obstetrics and Gynecology, Medical School, University of Thessalia, 41110 Larissa, Greece (FAX: 30-2410-670096).

Received 31 December 2008; received in revised form 15 April 2009; accepted 15 April 2009. published online 25 May 2009.

This study investigated the ovarian control of LH responsiveness to GnRH in anovulatory women with the polycystic ovary syndrome (PCOS). It is suggested that the enhanced pituitary sensitivity of LH secretion to GnRH in anovulatory women with PCOS is not due to a reduced production but rather to a defect in the interaction of ovarian factors on the hypothalamic–pituitary system.

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 K.D. has nothing to disclose. C.V. has nothing to disclose. S.P. has nothing to disclose. A.K. has nothing to disclose. I.E.M. has nothing to disclose.

PII: S0015-0282(09)00899-1

doi:10.1016/j.fertnstert.2009.04.033

Fertility and Sterility
Volume 92, Issue 4 , Pages 1378-1380, October 2009

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