Fertility and Sterility
Volume 92, Issue 4 , Pages 1378-1380 , October 2009

Ovarian control of pituitary sensitivity of luteinizing hormone secretion to gonadotropin-releasing hormone in women with the polycystic ovary syndrome

  • Konstantinos Dafopoulos, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Christos Venetis, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Spyros Pournaras, M.D.

      Affiliations

    • Department of Microbiology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Athanasios Kallitsaris, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • ,
  • Ioannis E. Messinis, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece
    • Corresponding Author InformationReprint requests: Ioannis E. Messinis, M.D., Ph.D., Department of Obstetrics and Gynecology, Medical School, University of Thessalia, 41110 Larissa, Greece (FAX: 30-2410-670096).

Received 31 December 2008 ,Revised 15 April 2009 ,Accepted 15 April 2009.

References 

  1. Balen AH, Conway GS, Kaltsas G, Techatrasak K, Manning PJ, West C, et al. Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients. Hum Reprod. 1995;10:2107–2111
  2. Hendriks ML, Brouwer J, Hompes PG, Homburg R, Lambalk CB. LH as a diagnostic criterion for polycystic ovary syndrome in patients with WHO II oligo/amenorrhoea. Reprod Biomed Online. 2008;16:765–771
  3. Mortimer RH, Lev-Gur M, Freeman R, Fleischer N. Pituitary response to bolus and continuous intravenous infusion of luteinizing hormone-releasing factor in normal women and women with polycystic ovarian syndrome. Am J Obstet Gynecol. 1978;130:630–634
  4. Patel K, Coffler MS, Dahan MH, Malcom PJ, Deutsch R, Chang RJ. Relationship of GnRH-stimulated LH release to episodic LH secretion and baseline endocrine-metabolic measures in women with polycystic ovary syndrome. Clin Endocrinol. 2004;60:67–74
  5. Messinis IE. Ovarian feedback, mechanism of action and possible clinical implications. Hum Reprod Update. 2006;12:557–571
  6. Messinis IE, Lolis D, Papadopoulos L, Tsahalina T, Papanikolaou N, Seferiadis K, et al. Effect of varying concentrations of follicle stimulating hormone on the production of gonadotrophin surge attenuating factor (GnSAF) in women. Clin Endocrinol. 1993;39:45–50
  7. Messinis IE, Lolis D, Zikopoulos K, Tsahalina E, Seferiadis K, Templeton AA. Effect of an increase in FSH on the production of gonadotrophin-surge-attenuating factor in women. J Reprod Fertil. 1994;101:689–695
  8. The Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group 2004. Revised (2003) consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Hum Reprod. 2003;19:41–47
  9. Lolis DE, Tsolas O, Messinis IE. The follicle-stimulating hormone threshold level for follicle maturation in superovulated cycles. Fertil Steril. 1995;63:1272–1277
  10. Wang CF, Lasley BL, Lein A, Yen SC. The functional changes of the pituitary gonadotrophs during the menstrual cycle. J Clin Endocrinol Metab. 1976;42:718–728
  11. Fiad TM, Cunningham SK, McKenna TJ. Role of progesterone deficiency in the development of luteinizing hormone and androgen abnormalities in polycystic ovary syndrome. Eur J Endocrinol. 1996;135:335–339
  12. Dafopoulos K, Kotsovassilis CG, Milingos S, Kallitsaris A, Galazios G, Zintzaras E, et al. Changes in pituitary sensitivity to GnRH in estrogen-treated post-menopausal women: evidence that gonadotrophin surge attenuating factor plays a physiological role. Hum Reprod. 2004;19:1985–1992
  13. Karligiotou E, Kollia P, Kallitsaris A, Messinis IE. Expression of human serum albumin (HSA) mRNA in human granulosa cells: potential correlation of the 95 amino acid long carboxyl terminal of HSA to gonadotrophin surge-attenuating factor. Hum Reprod. 2006;21:644–650
  14. Anderson RA, Groome NP, Baird DT. Inhibin A and inhibin B in women with polycystic ovarian syndrome during treatment with FSH to induce mono-ovulation. Clin Endocrinol. 1998;48:577–584
  15. Smanik EJ, Young HK, Muldoon TG, Mahesh VB. Analysis of the effect of progesterone in vivo on estrogen receptor distribution in the rat anterior pituitary and hypothalamus. Endocrinology. 1983;113:15–22
  16. Blaustein JD, Brown TJ. Progesterone decreases the concentration of hypothalamic and anterior pituitary estrogen receptors in ovariectomized rats. Brain Res. 1984;304:225–236
  17. Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Comparison of follicle-stimulating-hormone-stimulated dimeric inhibin and estradiol responses as indicators of granulosa cell function in polycystic ovary syndrome and normal women. J Clin Endocrinol Metab. 2006;91:2920–2925
  18. Messinis IE, Milingos S, Zikopoulos K, Kollios G, Seferiadis K, Lolis D. Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone. Hum Reprod. 1998;13:1152–1156

 K.D. has nothing to disclose. C.V. has nothing to disclose. S.P. has nothing to disclose. A.K. has nothing to disclose. I.E.M. has nothing to disclose.

PII: S0015-0282(09)00899-1

doi: 10.1016/j.fertnstert.2009.04.033

Fertility and Sterility
Volume 92, Issue 4 , Pages 1378-1380 , October 2009

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