Fertility and Sterility
Volume 92, Issue 4 , Pages 1381-1383 , October 2009

Genetic variation in the vitamin D receptor and polycystic ovary syndrome risk

  • Touraj Mahmoudi, M.Sc.

      Affiliations

    • Corresponding Author InformationReprint requests: Touraj Mahmoudi, M.Sc., Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute, 5 Hafez Street, BaniHashem Square,19395-4644, Tehran, Iran (FAX: +982122305236).

Received 29 January 2009 ,Revised 19 April 2009 ,Accepted 5 May 2009.

References 

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  2. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocr Diab. 2006;114:577–583
  3. Panidis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, et al. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin Chem. 2005;51:1691–1697
  4. Mahmoudi T, Gourabi H, Ashrafi M, Yazdi RS, Ezabadi Z. Calciotropic hormones, insulin resistance and the polycystic ovary syndrome. Fertil Steril. Published online February 20, 2009 [Epub ahead of print].
  5. Chiu KC, Chuang LM, Yoon C. The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet. 2001;2:2
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  8. Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In:  Dunaif A,  Givens JR,  Haseltine FP,  Merriam GE,  Hershman SM editor. Polycystic ovary syndrome. Current issues in endocrinology and metabolism. Boston: Blackwell; 1992;p. 377–384
  9. Harris SS, Eccleshall TR, Gross C, Dawson-Hughes B, Feldman D. The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American Black and White women. J Bone Miner Res. 1997;12:1043–1048
  10. Ye WZ, Reis AF, Velho G. Identification of a novel Tru9I polymorphism in the human vitamin D receptor gene. J Hum Genet. 2000;45:56–57
  11. Talor JA, Hirvonen A, Watson M, Pittman G, Mohler JL, Bell DA. Association of prostate cancer with vitamin D receptor gene polymorphism. Cancer Res. 1996;56:4108–4110
  12. Sun G, Vasdev S, Martin GR, Gadag V, Zhang H. Altered calcium homeostasis is correlated with abnormalities of fasting serum glucose, insulin resistance, and β-cell function in the Newfoundland population. Diabetes. 2005;54:3336–3339
  13. Gennari L, Becherini L, Masi L, Gonnelli S, Cepollaro C, Martini S, et al. Vitamin D receptor genotypes and intestinal calcium absorption in postmenopausal women. J Clin Endocrinol Metab. 1997;82:1772–1775
  14. Whitfield GK, Remus LS, Jurutka PW, Zitzer H, Oza AK, Dang HT, et al. Functionally relevant polymorphisms in the human nuclear vitamin D receptor gene. Mol Cell Endocrinol. 2001;177:145–159

 T.M. has nothing to disclose.

 Supported by a grant from the Royan Institute, Tehran, Iran.

PII: S0015-0282(09)01071-1

doi: 10.1016/j.fertnstert.2009.05.002

Fertility and Sterility
Volume 92, Issue 4 , Pages 1381-1383 , October 2009

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