Fertility and Sterility
Volume 92, Issue 2 , Pages 828.e7-828.e10 , August 2009

Singleton birth after preimplantation genetic diagnosis for Huntington disease using whole genome amplification

  • Judy F.C. Chow, M.Phil.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong
    • ,
  • William S.B. Yeung, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong
    • Corresponding Author InformationReprint requests: William S. B. Yeung, Department of Obstetrics and Gynaecology, University of Hong Kong, Pokfulam, Hong Kong (FAX: 852-2816-1947).
    • ,
  • Estella Y.L. Lau, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, Queen Mary Hospital, Pokfulam, Hong Kong
    • ,
  • Stephen T.S. Lam, M.D.

      Affiliations

    • Clinical Genetic Service, Department of Health, Hong Kong
    • ,
  • Tony Tong, M.Sc.

      Affiliations

    • Clinical Genetic Service, Department of Health, Hong Kong
    • ,
  • Ernest H.Y. Ng, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong
    • ,
  • Pak-Chung Ho, M.D.

      Affiliations

    • Department of Obstetrics and Gynaecology, University of Hong Kong, Hong Kong

Received 25 March 2009 ,Revised 20 April 2009 ,Accepted 7 May 2009.

References 

  1. Walker FO. Huntington's disease. Lancet. 2007;369(9557):218–228
  2. Ross CA, Poirier MA. Protein aggregation and neurodegenerative disease. Nat Med. 2004;10(Suppl):S10–S17
  3. Sermon K, Goossens V, Seneca S, Lissens W, De Vos A, Vandervorst M, et al. Preimplantation diagnosis for Huntington's disease (HD): clinical application and analysis of the HD expansion in affected embryos. Prenat Diagn. 1998;18:1427–1436
  4. Moutou C, Gardes N, Viville S. New tools for preimplantation genetic diagnosis of Huntington's disease and their clinical applications. Eur J Hum Genet. 2004;12:1007–1014
  5. Jasper MJ, Hu DG, Liebelt J, Sherrin D, Watson R, Tremellen KP, et al. Singleton births after routine preimplantation genetic diagnosis using exclusion testing (D4S43 and D4S126) for Huntington's disease. Fertil Steril. 2006;85:597–602
  6. Hosono S, Frauqi F, Dean FB. Unbiased whole-genome amplification directly from clinical samples. Genome Res. 2003;13:954–964
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  9. Lledo B, Ten H, Galan FM, Bernabeu R. Preimplantation genetic diagnosis of Marfan syndrome using multiple displacement amplification. Fertil Steril. 2006;86:949–955
  10. Ren Z, Zeng HT, Xu YW, Zhuang GL, Deng J, Zhang C, et al. Preimplantation genetic diagnosis for Duchenne muscular dystrophy by multiple displacement amplification. Fertil Steril. 2009;91:359–364
  11. Burlet P, Frydman N, Gigarel N, Kerbrat V, Tachdjian G, Feyereisen E, et al. Multiple displacement amplification improves PGD for fragile X syndrome. Mol Hum Reprod. 2006;12:647–652
  12. Hellani A, Coskun S, Tbakhi A, Al-Hassan S. Clinical application of multiple displacement amplification in preimplantation genetic diagnosis. Reprod Biomed Online. 2005;10:376–380
  13. Ng EHY, Yeung WSB, Lau EYL, So WWK, Ho PC. High serum oestradiol levels in fresh IVF cycles do not impair implantation and pregnancy rates in subsequent FET cycles. Hum Reprod. 2000;15:250–255
  14. Handyside A, Robinson MD, Simpson RJ, Omar MB, Shaw M-A, Grudzinskas JG, et al. Isothermal whole genom amplification from single and small numbers of cells: a new era for preimplantation genetic diagnosis of inherited disease. Mol Hum Reprod. 2004;10:767–772
  15. Ng EH, Lau EY, Yeung WS, Lau ET, Tang MH, Ho PC. Pre-implantation genetic diagnosis in Hong Kong. Hong Kong Med J. 2003;9:43–47
  16. Chan V, Ng EH, Yam I, Yeung WS, Ho PC, Chan TK. Experience in preimplantation genetic diagnosis for exclusion of homozygous alpha degrees thalassemia. Prenat Diagn. 2006;26:1029–1036
  17. Girardet A, Fernandez C, Claustres M. Efficient strategies for preimplantation genetic diagnosis of spinal muscular atrophy. Fertil Steril. 2008;90(443):e7–12
  18. Esteban JA, Salas M, Blanco L. Fidelity of phi 29 DNA polymerase. Comparison between protein-primed initiation and DNA polymerization. J Biol Chem. 1993;268:2719–2726
  19. Verlinsky Y, Kuliev A. An atlas of preimplantation genetic diagnosis. 2nd ed.. New York: Parthenon Publishing Group; 2005;54

 J.C. has nothing to disclose. W.Y. has nothing to disclose. E.L. has nothing to disclose. S.L. has nothing to disclose. T.T. has nothing to disclose. E.N. has nothing to disclose. P.-C.H. has nothing to disclose.

PII: S0015-0282(09)01083-8

doi: 10.1016/j.fertnstert.2009.05.007

Fertility and Sterility
Volume 92, Issue 2 , Pages 828.e7-828.e10 , August 2009

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