Fertility and Sterility
Volume 94, Issue 4 , Pages 1320-1327 , September 2010

Infant outcome of 957 singletons born after frozen embryo replacement: The Danish National Cohort Study 1995–2006

  • Anja Pinborg, M.D., D.M.Sci.

      Affiliations

    • Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • Corresponding Author InformationReprint requests: Anja Pinborg, M.D., D.M.Sci., Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark (FAX: 45-35-45-46-49).
    • ,
  • Anne Loft, M.D.

      Affiliations

    • Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Anna-Karina Aaris Henningsen, M.D.

      Affiliations

    • Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
    • ,
  • Steen Rasmussen, M.Sc.

      Affiliations

    • Department of Health Statistics, Danish National Board of Health, Copenhagen, Denmark
    • ,
  • Anders Nyboe Andersen, M.D., D.M.Sci.

      Affiliations

    • Fertility Clinic, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark

Received 1 April 2009 ,Revised 14 May 2009 ,Accepted 21 May 2009.

References 

  1. Zeilmaker GH, Alberda AT, van Gent I, Rijkmans CM, Drogendijk AC. Two pregnancies following transfer of intact frozen-thawed embryos. Fertil Steril. 1984;42:293–296
  2. Andersen AN, Goossens V, Ferraretti AP, Bhattacharya S, Felberbaum R, de Mouzon J, et al. European IVF-monitoring (EIM) Consortium; European Society of Human Reproduction and Embryology (ESHRE). Assisted reproductive technology in Europe, 2004: results generated from European registers by ESHRE. Hum Reprod. 2008;23:756–771
  3. Bergh T, Ericson A, Hillensjö T, Nygren KG, Wennerholm UB. Deliveries and children born after in-vitro fertilisation in Sweden 1982–95: a retrospective cohort study. Lancet. 1999;354:1579–1585
  4. Gerris J, De Neubourg D, De Sutter P, Van Royen E, Mangelschots K, Vercruyssen M. Cryopreservation as a tool to reduce multiple birth. Reprod Biomed Online. 2003;7:286–294
  5. Thurin A, Hausken J, Hillensjö T, Jablonowska B, Pinborg A, Strandell A, et al. Elective single-embryo transfer versus double-embryo transfer in in vitro fertilization. N Engl J Med. 2004;351:2392–2402
  6. Pinborg A. IVF/ICSI twin pregnancies: risks and prevention. Hum Reprod Update. 2005;11:575–593
  7. Wada I, Macnamee MC, Wick K, Bradfield JM, Brinsden PR. Birth characteristics and perinatal outcome of babies conceived from cryopreserved embryos. Hum Reprod. 1994;9:543–546
  8. Sutcliffe AG, D'Souza SW, Cadman J, Richards B, McKinlay IA, Lieberman B. Outcome in children from cryopreserved embryos. Arch Dis Child. 1995;72:290–293
  9. Wennerholm UB, Hamberger L, Nilsson L, Wennergren M, Wikland M, Bergh C. Obstetric and perinatal outcome of children conceived from cryopreserved embryos. Hum Reprod. 1997;12:1819–1825
  10. Wennerholm UB, Albertsson-Wikland K, Bergh C, Hamberger L, Niklasson A, Nilsson L, et al. Postnatal growth and health in children born after cryopreservation of embryos. Lancet. 1998;351:1085–1090
  11. Källén B, Finnström O, Nygren KG, Olausson PO. In vitro fertilization (IVF) in Sweden: infant outcome after different IVF fertilization methods. Fertil Steril. 2005;84:611–617
  12. Källén B, Finnström O, Nygren KG, Olausson PO. In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods. Birth Defects Res. 2005;73:162–169
  13. Belva F, Henriet S, Van den Abbeel E, Camus M, Devroey P, Van der Elst J, et al. Neonatal outcome of 937 children born after transfer of cryopreserved embryos obtained by ICSI and IVF and comparison with outcome data of fresh ICSI and IVF cycles. Hum Reprod. 2008;23:2227–2238
  14. Shih W, Rushford DD, Bourne H, Garrett C, McBain JC, Healy DL, et al. Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection. Hum Reprod. 2008;23:1644–1653
  15. Nygren KG, Finnström O, Källén B, Olausson PO. Population-based Swedish studies of outcomes after in vitro fertilisation. Acta Obstet Gynecol. 2007;86:774–782
  16. Draper ES, Kurinczuk JJ, Abrams KR, Clarke M. Assessment of separate contributions to perinatal mortality of infertility history and treatment: a case-control analysis. Lancet. 1999;22:1746–1749
  17. Basso O, Baird DD. Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort. Hum Reprod. 2003;18:2478–2484
  18. Basso O, Olsen J. Subfecundity and neonatal mortality: longitudinal study within the Danish National Birth Cohort. Br Med J. 2005;330:393–394
  19. Zhu JL, Basso O, Obel C, Bille C, Olsen J. Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. Br Med J. 2006;333:679
  20. Sun Y, Vestergaard M, Christensen J, Zhu JL, Bech BH, Olsen J. Epilepsy and seizures in children of treated and untreated subfertile couples. Hum Reprod. 2007;22:215–220
  21. Zhu JL, Basso O, Obel C, Hvidtjørn D, Olsen J. Infertility, infertility treatment and psychomotor development: the Danish National Birth Cohort. Paediatr Perinat Epidemiol. 2009;23:98–106
  22. Griesinger G, Kolibianakis EM, Diedrich K, Ludwig M. Ovarian stimulation for IVF has no quantitative association with birthweight: a registry study. Hum Reprod. 2008;23:2549–2554
  23. Ombelet W, Martens G, De Sutter P, Gerris J, Bosmans E, Ruyssinck G, et al. Perinatal outcome of 12,021 singleton and 3108 twin births after non-IVF-assisted reproduction: a cohort study. Hum Reprod. 2006;21:1025–1032
  24. Klemetti R, Sevóon T, Gissler M, Hemminiki E. Health of children born after ovulation induction. Fertil Steril. Published online January 24, 2009 [Epub ahead of print].
  25. Aytoz A, Van den Abbeel E, Bonduelle M, Camus M, Joris H, Van Steirteghem A, et al. Obstetric outcome of pregnancies after the transfer of cryopreserved and fresh embryos obtained by conventional in-vitro fertilization and intracytoplasmic sperm injection. Hum Reprod. 1999;14:2619–2624
  26. De Geyter C, De Geyter M, Steimann S, Zhang H, Holzgreve W. Comparative birth weights of singletons born after assisted reproduction and natural conception in previously infertile women. Hum Reprod. 2006;21:705–712
  27. Hansen M, Bower C, Milne E, de Klerk N, Kurinczuk JJ. Assisted reproductive technologies and the risk of birth defects—a systematic review. Hum Reprod. 2005;20:328–338
  28. El-Chaar D, Yang Q, Gao J, Bottomley J, Leader A, Wu Wen S, et al. Risk of birth defects increased in pregnancies conceived by assisted human reproduction. Fertil Steril. Published online October 28, 2008 [Epub ahead of print].
  29. Klemetti R, Gissler M, Sevón T, Koivurova S, Ritvanen A, Hemminki E. Children born after assisted fertilization have an increased rate of major congenital anomalies. Fertil Steril. 2005;84:1300–1307
  30. Lie RT, Lyngstadaas A, Ørstavik KH, Bakketeig LS, Jacobsen G, Tanbo T. Birth defects in children conceived by ICSI compared with children conceived by other IVF-methods; a meta-analysis. Int J Epidemiol. 2005;34:696–701
  31. Källén B, Finnström O, Nygren KG, Olausson PO. In vitro fertilization in Sweden: child morbidity including cancer risk. Fertil Steril. 2005;84:605–610
  32. Lidegaard O, Pinborg A, Andersen AN, Danish IVF. Imprinting diseases National IVF cohort study. Hum Reprod. 2005;20:950–954
  33. Fedder J, Gabrielsen A, Humaidan P, Erb K, Ernst E, Loft A. Malformation rate and sex ratio in 412 children conceived with epididymal or testicular sperm. Hum Reprod. 2007;22:1080–1085
  34. Luke B, Brown MB, Grainger DA, Baker VL, Ginsburg E, Stern JE. Society for Assisted Reproductive Technology Writing Group. The sex ratio of singleton offspring in assisted-conception pregnancies. Fertil Steril. Published online October 31, 2008 [Epub ahead of print].

 A.P. has nothing to disclose. A.L. has nothing to disclose. A.-K.A.H. has nothing to disclose. S.R. has nothing to disclose. A.N.A. has nothing to disclose.

PII: S0015-0282(09)01297-7

doi: 10.1016/j.fertnstert.2009.05.091

Fertility and Sterility
Volume 94, Issue 4 , Pages 1320-1327 , September 2010

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