Fertility and Sterility
Volume 94, Issue 4 , Pages 1212-1217 , September 2010

The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer

  • Constanze Banz, M.D.

      Affiliations

    • Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
    • ,
  • Ute Ungethuem, Ph.D.

      Affiliations

    • Laboratory for Functional Genomic Research, Campus Charité Mitte, Berlin, Germany
    • ,
  • Ralf-Juergen Kuban, Ph.D.

      Affiliations

    • Biochemical Institute, Campus Charité Mitte, Berlin, Germany
    • ,
  • Klaus Diedrich, M.D., Ph.D.

      Affiliations

    • Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
    • ,
  • Ernst Lengyel, M.D., Ph.D.

      Affiliations

    • Department of Gynecology and Obstetrics, Section of Gynecologic Oncology, University of Chicago, Chicago, Illinois
    • ,
  • Daniela Hornung, M.D., Ph.D.

      Affiliations

    • Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany
    • Corresponding Author InformationReprint requests: Daniela Hornung, M.D., Ph.D., Department of Gynecology and Obstetrics, University of Schleswig-Holstein, Campus Luebeck, Ratzeburgerallee 160, 23538 Luebeck, Germany (FAX: +49 451 500 2139).

Received 23 November 2008 ,Revised 4 May 2009 ,Accepted 20 June 2009.

References 

  1. Rice VM. Conventional medical therapies for endometriosis. Ann N Y Acad Sci. 2002;955:343–352
  2. Coxhead D, Thomas EJ. The familial inheritance of endometriosis in a British population: a case control study. J Obstet Gynaecol. 1993;13:42–44
  3. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, et al. Ovarian cancer risk associated with varying causes of infertility. Fertil Steril. 2004;82:405–414
  4. Clement PB, Seidman JD, Russell P, Kurman RJ. Diseases of the peritoneum. In:  Kurman RJ editors. Blaustein's pathology of the female genital tract. 5th ed. New York: Springer; 2002;p. 746–768791–905
  5. Stern RC, Dash R, Bentley RC, Snyder MJ, Haney AF, Robboy SJ. Malignancy in endometriosis: frequency and comparison of ovarian and extraovarian types. Int J Gynecol Pathol. 2001;20:133–139
  6. Erzen M, Rakar S, Klancnik B, Syrjänen K. Endometriosis-associated ovarian carcinoma (EAOC): an entity distinct from other ovarian carcinomas as suggested by a nested case-control study. Gynecol Oncol. 2001;83:100–108
  7. Modesitt SC, Tortolero-Luna G, Robinson JB, Gershenson DM, Wolf JK. Ovarian and extraovarian endometriosis–associated cancer. Obstet Gynecol. 2002;100:788–795
  8. Prowse AH, Manek S, Varma R, Liu J, Godwin AK, Maher ER, et al. Molecular genetic evidence that endometriosis is a precursor of ovarian cancer. Int J Cancer. 2006;119:556–562
  9. Ozols RF, Bookman MA, Connolly DC, Daly MB, Godwin AK, Schilder RJ, et al. Focus on epithelial ovarian cancer. Cancer Cell. 2004;5:19–24
  10. Ho HN, Wu MY, Yang YS. Peritoneal cellular immunity and endometriosis. Am J Reprod Immunol. 1997;38:400–412
  11. Oral E, Olive DL, Arici A. The peritoneal environment in endometriosis. Hum Reprod Update. 1996;2:385–398
  12. Nothnick WB. Treating endometriosis as an autoimmune disease. Fertil Steril. 2001;76:223–231
  13. Yoshimura T, Leonard EJ. Secretion by human fibroblasts of monocyte chemoattractant protein-1, the product of gene JE. J Immunol. 1990;144:2377–2383
  14. Arici A, Oral E, Attar E, Tazuke SI, Olive DL. Monocyte chemotactic protein-1 concentration in peritoneal fluid in patients with endometriosis and its modulation in human mesothelial cells. Fertil Steril. 1997;67:1065–1072
  15. Van Damme J, Struyf S, Opdenakker G. Chemokine-protease interactions in cancer. Semin Cancer Biol. 2004;14:201–208
  16. Strizzi L, Bianco C, Normanno N, Salomon D. Cripto-1: a multifunctional modulator during embryogenesis and oncogenesis. Oncogene. 2005;24:5731–5741
  17. D'Antonio A, Losito S, Pignata S, Grassi M, Perrone F, De Luca A, et al. Transforming growth factor alpha, amphiregulin and cripto-1 are frequently expressed in advanced human ovarian carcinomas. Int J Oncol. 2002;21:941–948
  18. Sugawara T, Holt JA, Driscoll D, Strauss JF, Lin D, Miller WF, et al. Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13. Proc Nat Acad Sci U S A. 1995;92:4778–4782
  19. Attar E, Bulun SE. Aromatase and other steroidogenic genes in endometriosis: translational aspects. Hum Reprod Update. 2006;12:49–56
  20. Abd-Elaziz M, Moriya T, Akahira J, Suzuki T, Sasano H. StAR and progesterone producing enzymes (3beta-hydroxysteroid dehydrogenase and cholesterol side-chain cleavage cytochromes P450) in human epithelial ovarian carcinoma: immunohistochemical and real-time PCR studies. Cancer Sci. 2005;96:232–239
  21. Shimomura T, Denda K, Kitamura A, Kawaguchi T, Kito M, Kondo J, et al. Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor. J Biol Chem. 1997;272:6370–6376
  22. Parr C, Watkins G, Mansel RE, Jiang WG. The hepatocyte growth factor regulatory factors in human breast cancer. Clin Cancer Res. 2004;10:202–211
  23. Stimpfl M, Schmid BC, Schiebel I, Tong D, Leodolter S, Obermair A, et al. Expression of mucins and cytokeratins in ovarian cancer cell lines. Cancer Lett. 1999;145:133–141
  24. Fillies T, Werkmeister R, Packeisen J, Brandt B, Morin P, Weingart D, et al. Cytokeratin 8/18 expression indicates poor prognosis in sqamous cell carcinoma of the oral cavity. BMC Cancer. 2006;13:6–10
  25. Kim IM, Ackerson T, Ramakrishna S, Tretiakova M, Wang IC, Kalin TV, et al. The Forkhead Box m1 transcription factor stimulates the proliferation of tumor cells during development of lung cancer. Cancer Res. 2006;66:2153–2161
  26. Campbell IG, Jones TA, Foulkes WD, Trowsdale J. Folate-binding protein is a marker for ovarian cancer. Cancer Res. 1991;51:5329–5338
  27. Hibbs K, Skubitz KM, Pambuccian SE, Casey RC, Burleson KM, Oegema TR, et al. Differential gene expression in ovarian carcinoma. Am J Pathol. 2004;165:397–414
  28. Palan PR, Romney SL. Cellular binding proteins for vitamin A in human carcinomas and in normal tissue. Cancer Res. 1980;40:4221–4224
  29. Zheng JY, Yu D, Foroohar M, Ko E, Chan J, Kim N, et al. Regulation of the expression of the prostate-specific antigen by claudin-7. J Membr Biol. 2003;194:187–197
  30. Kominsky SL, Argani P, Korz D, Evron E, Ramann V, Garrett E, et al. Loss of tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast. Oncogene. 2003;22:2021–2033
  31. Terris B, Blaveri E, Crnogorac-Jurcevic T, Jones M, Missiaglia E, Ruszniewski P, et al. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas. Am J Pathol. 2002;160:1745–1754
  32. Hough CD, Sherman-Baust CA, Pizer ES, Montz FJ, Im DD, Rosenheins NB, et al. Large-scale serial analysis of gene expression reveals genes differentially expressed in ovarian cancer. Cancer Res. 2000;60:6281–6287

 C.B. has nothing to disclose. U.U. has nothing to disclose. R.-J.K. has nothing to disclose. K.D. has nothing to disclose. E.L. has nothing to disclose. D.H. has nothing to disclose.

PII: S0015-0282(09)01412-5

doi: 10.1016/j.fertnstert.2009.06.039

Fertility and Sterility
Volume 94, Issue 4 , Pages 1212-1217 , September 2010

Article Tools