Fertility and Sterility
Volume 92, Issue 4 , Pages 1497.e1-1497.e4 , October 2009

Is classic pericentric inversion of chromosome 2 inv(2)(p11q13) associated with an increased risk of unbalanced chromosomes?

  • Fatma Ferfouri, M.Sc.

      Affiliations

    • Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France
    • EA 2493, UVSQ, Versailles, France
    • ,
  • Patrice Clement, Pharm.D

      Affiliations

    • Laboratoire Clement, Le Blanc-Mesnil, France
    • ,
  • Denise Molina Gomes, M.D., Ph.D

      Affiliations

    • Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France
    • EA 2493, UVSQ, Versailles, France
    • ,
  • Marie Minz, M.D

      Affiliations

    • Laboratoire Clement, Le Blanc-Mesnil, France
    • ,
  • Edouard Amar, M.D

      Affiliations

    • American Hospital of Paris, Neuilly sur Seine, France
    • ,
  • Jacqueline Selva, M.D., Ph.D.

      Affiliations

    • Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France
    • EA 2493, UVSQ, Versailles, France
    • ,
  • François Vialard, Pharm.D, Ph.D

      Affiliations

    • Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, Poissy, France
    • EA 2493, UVSQ, Versailles, France
    • Corresponding Author InformationReprint requests: François Vialard, Pharm.D., Department of Reproductive Biology, Cytogenetics, Gynecology, and Obstetrics, Centre Hospitalier Poissy Saint Germain, 10 rue du Champ Gaillard, 78 303 Poissy, France (FAX: 33-1-39-27-44-25).

Received 24 April 2009 ,Revised 11 June 2009 ,Accepted 18 June 2009.

References 

  1. Gardner RJM, Sutherland GR. Chromosome abnormalities and genetic counseling. 2nd ed.. New York: Oxford University Press; 1996;
  2. De Braekeleer M, Dao TN. Cytogenetic studies in male infertility: a review. Hum Reprod. 1991;6:245–250
  3. Gabriel-Robez O, Ratomponirina C, Rumpler Y, Marec Le, Luciani JM, Guichaoua MR. Synapsis and synaptic adjustment in an infertile human male heterozygous for a pericentric inversion in chromosome 1. Hum Genet. 1986;72:148–152
  4. Djalali M, Steinbach P, Bullerdiek J, Holmes-Siedle M, Verschraegen-Spae MR, Smith A. The significance of pericentric inversions of chromosome 2. Hum Genet. 1986;72:32–36
  5. Anton E, Blanco J, Egozcue J, Vidal F. Sperm studies in heterozygote inversion carriers: a review. Cytogenet Genome Res. 2005;111:297–304
  6. Morel F, Laudier B, Guerif F, Couet ML, Royere D, Roux C, et al. Meiotic segregation analysis in spermatozoa of pericentric inversion carriers using fluorescence in-situ hybridization. Hum Reprod. 2007;22:136–141
  7. Roux C, Tripogney C, Morel F, Joanne C, Fellmann F, Clavequin MC, et al. Segregation of chromosomes in sperm of Robertsonian translocation carriers. Cytogenet Genome Res. 2005;111:291–296
  8. Lindenbaum RH, Hulten M, McDermott A, Seabright M. The prevalence of translocations in parents of children with regular trisomy 21: a possible interchromosomal effect?. J Med Genet. 1985;22:24–28
  9. Kirkpatrick G, Ferguson KA, Gao H, Tang S, Chow V, Yuen BH, et al. A comparison of sperm aneuploidy rates between infertile men with normal and abnormal karyotypes. Hum Reprod. 2008;23:1679–1683
  10. Douet-Guilbert N, Bris MJ, Amice V, Marchetti C, Delobel B, Amice J, et al. Interchromosomal effect in sperm of males with translocations: report of 6 cases and review of the literature. Int J Androl. 2005;28:372–379
  11. Machev N, Gosset P, Warter S, Treger M, Schillinger M, Viville S. Fluorescence in situ hybridization sperm analysis of six translocation carriers provides evidence of an interchromosomal effect. Fertil Steril. 2005;84:365–373
  12. Escudero T, Lee M, Stevens J, Sandalinas M, Munne S. Preimplantation genetic diagnosis of pericentric inversions. Prenat Diagn. 2001;21:760–766
  13. Vialard F, Hammoud I, Molina-Gomes D, Wainer R, Bergere M, Albert M, et al. Gamete cytogenetic study in couples with implantation failure: aneuploidy rate is increased in both couple members. J Assist Reprod Genet. 2008;25:539–545

 F.F. has nothing to disclose. P.C. has nothing to disclose. D.M.G. has nothing to disclose. M.M. has nothing to disclose. E.A. has nothing to disclose. J.S. has nothing to disclose. F.V. has nothing to disclose.

PII: S0015-0282(09)01420-4

doi: 10.1016/j.fertnstert.2009.06.047

Fertility and Sterility
Volume 92, Issue 4 , Pages 1497.e1-1497.e4 , October 2009

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