Fertility and Sterility
Volume 93, Issue 1 , Pages 286-288 , 1 January 2010

A short period of ejaculatory abstinence before intrauterine insemination is associated with higher pregnancy rates

  • Paul B. Marshburn, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte
    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte
    • Corresponding Author InformationReprint requests: Paul B. Marshburn, M.D., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Carolinas Medical Center, 1000 Blythe Blvd., Charlotte, North Carolina 28232-2861 (TEL: 704-355-3153; FAX: 704-355-1941).
    • ,
  • Mark Alanis, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, South Carolina
    • ,
  • Michelle L. Matthews, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte
    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte
    • ,
  • Rebecca Usadi, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte
    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte
    • ,
  • Margaret H. Papadakis, Ph.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte
    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte
    • ,
  • Susan Kullstam, M.S.

      Affiliations

    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte
    • ,
  • Bradley S. Hurst, M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Carolinas Medical Center, Charlotte
    • Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte

Received 20 March 2009 ,Revised 27 June 2009 ,Accepted 8 July 2009.

References 

  1. Verhulst SM, Cohlen BJ, Hughes E, Heineman MJ, Velde ET. Intra-uterine insemination for unexplained subfertility. Cochrane Database Syst Rev. 2006;Oct 18;(4):CD001838
  2. Horvath PM, Bohrer M, Shelden RM, Kemmann E. The relationship of sperm parameters to cycle fecundity in superovulated women undergoing intrauterine insemination. Fertil Steril. 1989;52:288–294
  3. Van Voorhis BJ, Barnett M, Sparks AE, Syrop CH, Rosenthal G, Dawson J. Effect of the total motile sperm count on the efficacy and cost-effectiveness of intrauterine insemination and in vitro fertilization. Fertil Steril. 2001;75:661–668
  4. Freund M. Effect of frequency of emission on semen out-put and an estimate of daily sperm production in man. J Reprod Fertil. 1963;6:269–273
  5. Magnus O, Tollefsrud A, Abyholm T, Purvis K. Effects of varying the abstinence period in the same individuals on sperm quality. Arch Androl. 1991;26:199–203
  6. Jurema MW, Vieira AD, Bankowski B, Petrella C, Zhao Y, Wallach E, et al. Effect of ejaculatory abstinence period on the pregnancy rate after intrauterine insemination. Fertil Steril. 2005;84:678–681
  7. Testart J. Artificial insemination. Rev Prat. 1990;40:2711–2715
  8. Aitken RJ, Clarkson JS, Hargreave TB, Irvine DS, Wu FC. Analysis of the relationship between defective sperm function and the generation of reactive oxygen species in cases of oligozoospermia. J Androl. 1989;10:214–220
  9. Agarwal A, Saleh RA, Bedaiway MA. Role of reactive oxygen species in the pathophysiology of human reproduction. Fertil Steril. 2003;79:829–843
  10. Wilcox AJ, Weinberg CR, Baird DD. Timing of sexual intercourse in relation to ovulation. Effects on the probability of conception, survival of the pregnancy, and sex of the baby. N Engl J Med. 1995;333:1517–1521
  11. Bellinge BS, Copeland CM, Thomas TD, Mazzucchelli RE, O'Neil G, Cohen MJ. The influence of patient insemination on the implanatation rate in an in vitro fertilization and embryo transfer program. Fertil Steril. 1986;46:252–256
  12. von Wolff M, Rosner S, Thone C, Pinheiro RM, Jaukus J, Bruckner T, et al. Intravaginal and intracervical application of seminal plasma in in vitro fertilization of intracytoplasmic sperm injection treatment cycles–a double-blind, placebo-controlled, randomized pilot study. Fertil Steril. 2009;91:167–172

 Supported by the Health Services Foundation, Carolinas Medical Center, Charlotte, North Carolina.

 P.B.M. has nothing to disclose. M.A. has nothing to disclose. M.L.M. has nothing to disclose. R.U. has nothing to disclose. M.H.P. has nothing to disclose. S.K. has nothing to disclose. B.S.H. has nothing to disclose.

PII: S0015-0282(09)02462-5

doi: 10.1016/j.fertnstert.2009.07.972

Fertility and Sterility
Volume 93, Issue 1 , Pages 286-288 , 1 January 2010

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