Fertility and Sterility
Volume 93, Issue 1 , Pages 280-282, 1 January 2010

Coenzyme Q10 treatment reduces lipid peroxidation, inducible and endothelial nitric oxide synthases, and germ cell–specific apoptosis in a rat model of testicular ischemia/reperfusion injury

  • Bulent Erol, M.D.

      Affiliations

    • Department of Urology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Murat Bozlu, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    • Corresponding Author InformationReprint requests: Murat Bozlu, M.D., Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079-Mersin, Turkey (FAX: 90-324-337-4305).
    • ,
  • Volkan Hanci, M.D.

      Affiliations

    • Department of Anesthesiology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Husnu Tokgoz, M.D.

      Affiliations

    • Department of Urology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Sibel Bektas, M.D.

      Affiliations

    • Department of Pathology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Gorkem Mungan, M.D.

      Affiliations

    • Department of Biochemistry, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey

Received 11 May 2009; received in revised form 9 July 2009; accepted 10 July 2009. published online 14 August 2009.

In this experimental study, we assessed the preventive effects of coenzyme Q10 (CoQ10) in a rat model of ischemia/reperfusion injury. The results of this study show that CoQ10 administration before the reperfusion period of testicular torsion provides a significant decrease in testicular lipid peroxidation products and expressions of inducible nitric oxide synthase, endothelial nitric oxide synthase, and germ cell-specific apoptosis.

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 B.E. has nothing to disclose. M.B. has nothing to disclose. V.H. has nothing to disclose. H.T. has nothing to disclose. S.B. has nothing to disclose. G.M. has nothing to disclose.

PII: S0015-0282(09)02477-7

doi:10.1016/j.fertnstert.2009.07.981

Fertility and Sterility
Volume 93, Issue 1 , Pages 280-282, 1 January 2010

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