Fertility and Sterility
Volume 93, Issue 1 , Pages 280-282 , 1 January 2010

Coenzyme Q10 treatment reduces lipid peroxidation, inducible and endothelial nitric oxide synthases, and germ cell–specific apoptosis in a rat model of testicular ischemia/reperfusion injury

  • Bulent Erol, M.D.

      Affiliations

    • Department of Urology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Murat Bozlu, M.D.

      Affiliations

    • Department of Urology, University of Mersin School of Medicine, Mersin, Turkey
    • Corresponding Author InformationReprint requests: Murat Bozlu, M.D., Department of Urology, University of Mersin School of Medicine, Zeytinlibahce Caddesi, 33079-Mersin, Turkey (FAX: 90-324-337-4305).
    • ,
  • Volkan Hanci, M.D.

      Affiliations

    • Department of Anesthesiology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Husnu Tokgoz, M.D.

      Affiliations

    • Department of Urology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Sibel Bektas, M.D.

      Affiliations

    • Department of Pathology, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey
    • ,
  • Gorkem Mungan, M.D.

      Affiliations

    • Department of Biochemistry, Zonguldak Karaelmas University Faculty of Medicine, Zonguldak, Turkey

Received 11 May 2009 ,Revised 9 July 2009 ,Accepted 10 July 2009.

References 

  1. Visser AJ, Heyns CF. Testicular function after torsion of the spermatic cord. BJU Int. 2003;92:200–203
  2. Cuzzocrea S, Riley DP, Caputi AP, Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev. 2001;53:135–159
  3. Lysiak JJ, Nguyen QA, Kirby JL, Turner TT. Ischemia-reperfusion of the murine testis stimulates the expression of proinflammatory cytokines and activation of c-jun N-terminal kinase in a pathway to E-selectin expression. Biol Reprod. 2003;69:202–210
  4. Littarru GP, Tiano L. Clinical aspects of coenzyme Q10: an update. Curr Opin Clin Nutr Metab Care. 2005;8:641–646
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  9. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med. 1991;11:81–128
  10. Yagmurdur H, Ayyildiz A, Karaguzel E, Akgul T, Ustun H, Germiyanoglu C. Propofol reduces nitric oxide–induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. Acta Anaesthesiol Scand. 2008;52:350–357
  11. Turner TT, Tung KS, Tomomasa H, Wilson LW. Acute testicular ischemia results in germ cell–specific apoptosis in the rat. Biol Reprod. 1997;57:1267–1274
  12. Shirashi K, Naito K, Yoshida K. Nitric oxide promotes germ cell necrosis in the delayed phase after experimental teseticular torsion of rat. Biol Reprod. 2001;65:514–521
  13. Chew GT, Watts GF. Coenzyme Q10 and diabetic endotheliopathy: oxidative stress and the “recoupling hypothesis”. QJM. 2004;97:537–548
  14. Zuo Y, Xiang B, Yang J, Sun X, Wang Y, Chang H, et al. Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with APAF-1. Cell Res. 2009;19:449–457
  15. Lysiak JJ, Zheng S, Woodson R, Turner TT. Caspase-9–dependent pathway to murine germ cell apoptosis: mediation by oxidative stress, BAX, and caspase 2. Cell Tissue Res. 2007;328:411–419
  16. Witort E, Pattarino J, Papucci L, Schiavone N, Donnini M, Lapucci A, et al. Autologous lipofilling: coenzyme Q10 can rescue adipocytes from stress-induced apoptotic death. Plast Reconstr Surg. 2007;119:1191–1199
  17. Wu KLH, Hsu C, Chan JYH. Impairment of the mitochondrial respiratory enzyme activity triggers sequential activation of apoptosis-inducing factor–dependent and caspase-dependent signaling pathways to induce apoptosis after spinal cord injury. J Neurochem. 2007;101:1552–1566
  18. Dokmeci D, Kanter M, Inan M, Aydogdu N, Basaran UN, Yalcin O, et al. Protective effects of ibuprofen on testicular torsion/detorsion–induced ischemia/reperfusion injury in rats. Arch Toxicol. 2007;81:655–663

 B.E. has nothing to disclose. M.B. has nothing to disclose. V.H. has nothing to disclose. H.T. has nothing to disclose. S.B. has nothing to disclose. G.M. has nothing to disclose.

PII: S0015-0282(09)02477-7

doi: 10.1016/j.fertnstert.2009.07.981

Fertility and Sterility
Volume 93, Issue 1 , Pages 280-282 , 1 January 2010

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