Fertility and Sterility
Volume 93, Issue 1 , Pages 322-324, 1 January 2010

Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats

  • Mohd Nizam Haron, M.Sc.

      Affiliations

    • Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Urban J.A. D'Souza, Ph.D.

      Affiliations

    • School of Medicine, Universiti Malaysia Sabah, Sabah, Malaysia
    • ,
  • Hasnan Jaafar, M.D., M.Med. (Pathol.)

      Affiliations

    • Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Rahimah Zakaria, M.B.B.S., Ph.D.

      Affiliations

    • Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Harbindar Jeet Singh, Ph.D.

      Affiliations

    • Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia
    • Corresponding Author InformationReprint requests: Harbindar Jeet Singh, Ph.D., Faculty of Medicine, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia (FAX: 60-355442831).

Received 11 September 2008; received in revised form 8 July 2009; accepted 15 July 2009. published online 25 August 2009.

Daily intraperitoneal injection of 5–30 μg/kg body weight of leptin for 42 days to adult rats decreases sperm count and increases the fraction of abnormal sperm.

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 M.N.H. has nothing to disclose. U.J.A.D. has nothing to disclose. H.J. has nothing to disclose. R.Z. has nothing to disclose. H.J.S. has nothing to disclose.

 This study was supported by a short-term research grant from Universiti Sains Malaysia.

PII: S0015-0282(09)02491-1

doi:10.1016/j.fertnstert.2009.07.995

Fertility and Sterility
Volume 93, Issue 1 , Pages 322-324, 1 January 2010

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