Fertility and Sterility
Volume 93, Issue 1 , Pages 322-324 , 1 January 2010

Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats

  • Mohd Nizam Haron, M.Sc.

      Affiliations

    • Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Urban J.A. D'Souza, Ph.D.

      Affiliations

    • School of Medicine, Universiti Malaysia Sabah, Sabah, Malaysia
    • ,
  • Hasnan Jaafar, M.D., M.Med. (Pathol.)

      Affiliations

    • Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Rahimah Zakaria, M.B.B.S., Ph.D.

      Affiliations

    • Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
    • ,
  • Harbindar Jeet Singh, Ph.D.

      Affiliations

    • Faculty of Medicine, Universiti Teknologi MARA, Selangor, Malaysia
    • Corresponding Author InformationReprint requests: Harbindar Jeet Singh, Ph.D., Faculty of Medicine, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia (FAX: 60-355442831).

Received 11 September 2008 ,Revised 8 July 2009 ,Accepted 15 July 2009.

References 

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  2. Waelput W, Brouckaert P, Brouckaert D, Tavernier J. A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update. Curr Med Chem. 2006;13:465–475
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  9. Hammoud AO, Wilde N, Gibson M, Parks A, Carrell DT, Meike AW. Male obesity and alteration in sperm parameters. Fertil Steril. 2008;90:2222–2225
  10. Narayana K, D'Souza UJ, Seetharama Rao KP. Ribavirin-induced sperm shape abnormalities in Wistar rat. Mutat Res. 2002;513:193–196
  11. Culling CFA, Allison RT, Barr WT. Cellular pathology technique. London: Butterworths; 1985;27–50
  12. Hermo L, Oko R, Robaire B. Epithelial cells of the epididymis show regional variations with respect to the secretion of endocytosis of immobilin as revealed by light and electron microscope immunocytochemistry. Anat Rec. 1992;232:202–220
  13. Hamrick MW, Della-Fera MA, Choi YH, Hartzell D, Pennington C, Baile CA. Injections of leptin into rat ventromedial hypothalamus increase adipocyte apoptosis in peripheral fat and in bone marrow. Cell Tissue Res. 2007;327:133–141
  14. Agarwal A, Prabakaran SA, Said TM. Prevention of oxidative stress injury to sperm. J Androl. 2005;26:654–660

 M.N.H. has nothing to disclose. U.J.A.D. has nothing to disclose. H.J. has nothing to disclose. R.Z. has nothing to disclose. H.J.S. has nothing to disclose.

 This study was supported by a short-term research grant from Universiti Sains Malaysia.

PII: S0015-0282(09)02491-1

doi: 10.1016/j.fertnstert.2009.07.995

Fertility and Sterility
Volume 93, Issue 1 , Pages 322-324 , 1 January 2010

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