Fertility and Sterility
Volume 92, Issue 4 , Pages 1497.e5-1497.e8 , October 2009

Non-Peutz-Jeghers syndrome associated ovarian sex cord tumor with annular tubules: a case report

  • Vladimir Nosov, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, UCLA Medical Center, University of California, Los Angeles, California
    • Department of Reproductive Medicine and Surgery, Moscow State University for Medicine and Dentistry, Moscow, Russia
    • ,
  • Susan Park, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, UCLA Medical Center, University of California, Los Angeles, California
    • ,
  • Jianyu Rao, M.D.

      Affiliations

    • Department of Pathology, UCLA Medical Center, University of California, Los Angeles, California
    • ,
  • Sanaz Memarzadeh, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, UCLA Medical Center, University of California, Los Angeles, California
    • Corresponding Author InformationReprint requests: Sanaz Memarzadeh, M.D., Ph.D., UCLA Department of Obstetrics and Gynecology, 10833 LeConte Avenue, Room 22-265 CHS, Los Angeles, CA 90095-1740 (FAX: 310-794-9110).

Received 20 April 2009 ,Revised 10 July 2009 ,Accepted 15 July 2009.

References 

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  2. Zumkeller W, Krause U, Holzhausen HJ, Hirsch W, Finke R, Burdach S. Brief report—ovarian sex cord tumor with annular tubules associated with precocious puberty. Med Pediatr Oncol. 2000;35:144–146
  3. Scully RE. Sex cord tumor with annular tubules: a distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer. 1970;25:1107–1121
  4. Young RH, Welch WR, Dickersin GR, Scully RE. Ovarian sex cord tumor with annular tubules: review of 74 cases including 27 with Peutz-Jeghers syndrome and 4 with adenoma malignum of the cervix. Cancer. 1982;50:1384–1402
  5. Scully RE. Hormonally active ovarian tumors. Verh Deutsch Ges Pathol. 1997;81:245–252
  6. Anderson MC, Govan AD, Langley FA, Woodcock AS, Tyagi SP. Ovarian sex cord tumor with annular tubules. Histopathology. 1980;4:137–145
  7. Sohl HM, Azoury RS, Najjar SS. Peutz-Jeghers syndrome associated with precocious puberty. J Pediatr. 1983;103:593–595
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  9. Ahn GH, Chi JG, Lee SK. Ovarian sex cord tumor with annular tubules. Cancer. 1986;57:1066–1073
  10. Kalifat R, de Brux J. Brief communication—ovarian sex cord tumor with annular tubules: an ultrastructural study. Int J Gynecol Pathol. 1987;6:380–388
  11. Laughlin EH. Benign and malignant neoplasms in a family with Peutz-Jeghers syndrome: study of three generations. South Med J. 1991;84:1205–1209
  12. Shen K, Wu PC, Lang JH, Huang RL, Tang MT, Lian LJ. Ovarian sex cord stromal tumors with annular tubules: a report of 6 cases. Gynecol Oncol. 1993;48:180–184
  13. Ayadi-Kaddour A, Bouraoui S, Bellil K, Bellil S, Kchir N, Zitouna MM, et al. Colonic adenocarcinoma and bilateral malignant ovarian sex cord tumor with annular tubules in Peutz-Jeghers syndrome. Pathologica. 2004;96:117–120
  14. Lele SM, Sawh RN, Zaharopoulos P, Adesokan A, Smith M, Linhart JM, et al. Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report. Mod Pathol. 2000;13:466–470
  15. Roth LM. Recent advances in the pathology and classification of ovarian sex cord-stromal tumors. Int J Gynecol Pathol. 2006;25:199–215
  16. Ciriş M, Erhan Y, Zekioglu O, Bayramoglu H. Inhibin alpha and beta expression in ovarian stromal tumors and their histological equivalence. Acta Obstet Gynecol Scand. 2004;83:491–496
  17. Crain JL. Ovarian sex cord tumor with annular tubules: steroid profile. Obstet Gynecol. 1986;68(3 Suppl):75S–79S
  18. Launonen V. Mutations in the human LKB1/STK11 gene. Hum Mutat. 2005;26:291–297
  19. Yinon Y, Beiner ME, Gotlieb WH, Korach Y, Perri T, Ben-Baruch G. Clinical outcome of cystectomy compared with unilateral salpingo-oophorectomy as fertility-sparing treatment of borderline ovarian tumors. Reprod Surg. 2007;88:479–484
  20. Mom CH, Engelen MJ, Willemse PH, Gietema JA, ten Hoor KA, de Vries EG, et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol. 2007;105:365–372
  21. Deavers MT, Malpica A, Liu J, Broaddus R, Silva EG. Ovarian sex cord-stromal tumors: an immunohistochemical study including a comparison of calretinin and inhibin. Mod Pathol. 2003;16:584–590
  22. Choi YL, Kim HS, Ahn G. Immunoexpression of inhibin alpha subunit, inhibin/activin beta A subunit and CD99 in ovarian tumors. Arch Pathol Lab Med. 2000;124:563–569

 V.N. has nothing to disclose. S.P. has nothing to disclose. J.R. has nothing to disclose. S.M. has nothing to disclose.

PII: S0015-0282(09)02498-4

doi: 10.1016/j.fertnstert.2009.07.1002

Fertility and Sterility
Volume 92, Issue 4 , Pages 1497.e5-1497.e8 , October 2009

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