Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes

Barton, Sara E.; Missmer, Stacey A.; Ashby, Rachel K.; Ginsburg, Elizabeth S.

doi:10.1016/j.fertnstert.2009.07.1672

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Volume 94, Issue 4 , Pages 1292-1295, September 2010

Multivariate analysis of the association between oocyte donor characteristics, including basal follicle stimulating hormone (FSH) and age, and IVF cycle outcomes

Data from the following study were presented in part at the American Society for Reproductive Medicine Annual Meeting, San Francisco, November 2008.

Sara E. Barton, M.D.
- Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
- Reprint requests: Sara E. Barton, M.D., Gynecology Services, ASB1-3, 75 Francis Street, Boston, MA 02115 (FAX: 617-975-0966).
Stacey A. Missmer, Sc.D.
- Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
- Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
- Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Rachel K. Ashby, M.D.
- Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts
Elizabeth S. Ginsburg, M.D.
- Division of Reproductive Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts

Received 18 April 2009; received in revised form 14 July 2009; accepted 21 July 2009. published online 12 October 2009.

Objective

To determine whether oocyte donor FSH and age are independently associated IVF cycle success.

Design

Retrospective cohort study.

Setting

University hospital-based IVF clinic.

Patient(s)

Three hundred twelve donor/recipient pairs undergoing oocyte donation IVF.

Main Outcome Measure(s)

Number of mature oocytes and embryos, clinical pregnancy, and live birth rates.

Result(s)

Donors' basal FSH levels were not associated with IVF cycle outcomes. However, for every year increase in donor age, the number of mature oocytes decreased by 0.39 and the number of embryos decreased by 0.25 resulting in 1 less embryo for each 4-year increase in age, even in young donors. For every 100 pg/mL increase in estradiol on the day of hCG administration, the number of mature oocytes increased by 0.49 and the number of embryos increased by 0.36. For each additional 75 IU of gonadotropin used during stimulation, the likelihood of pregnancy and live birth decreased by 3.5%.

Conclusion(s)

Donor oocyte IVF cycle outcomes were not associated with donor basal FSH. However, donor age and estradiol level on the day of hCG administration were significantly associated with numbers of mature oocytes and embryos obtained, and the amount of gonadotropin used in the stimulation was significantly associated with the likelihood of pregnancy and live birth.

Key Words: Oocyte donation, egg donation, donor FSH, donor age