Fertility and Sterility
Volume 93, Issue 4 , Pages 1356-1358, 1 March 2010

Longitudinal assessment of antimüllerian hormone during pregnancy—relationship with maternal adiposity, insulin, and adiponectin

  • Scott M. Nelson, Ph.D.

      Affiliations

    • Corresponding Author InformationReprint requests: Scott M. Nelson, Ph.D., Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow Royal Infirmary, 10 Alexandra Parade, Glasgow, G31 2ER, United Kingdom (FAX: 44-141-552-0873).
    • ,
  • Frances Stewart, M.D.
    • ,
  • Richard Fleming, Ph.D.
    • ,
  • Dilys J. Freeman, Ph.D.

Reproductive and Maternal Medicine, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom

Received 11 June 2009; received in revised form 22 July 2009; accepted 30 July 2009. published online 01 October 2009.

We examined in a prospective longitudinal pregnancy cohort the influence of advancing gestation and baseline maternal adiposity on antimüllerian hormone (AMH) and determined whether maternal hormones (insulin, leptin, adiponectin, E2, and sex hormone–binding globulin) correlate with alterations in AMH. We demonstrate that first-trimester AMH is associated negatively with maternal adiposity, that circulating levels decline during the second and third trimesters of pregnancy, and that in univariate and multivariate models adiponectin is associated positively with AMH during this period of pregnancy-related decline.

Key Words: Anti-müllerian hormone, pregnancy, adiposity, adiponectin, insulin

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 S.M.N. has nothing to disclose. F.S. has nothing to disclose. R.F. has nothing to disclose. D.J.F. has nothing to disclose.

PII: S0015-0282(09)03473-6

doi:10.1016/j.fertnstert.2009.07.1676

Fertility and Sterility
Volume 93, Issue 4 , Pages 1356-1358, 1 March 2010

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