Fertility and Sterility
Volume 93, Issue 4 , Pages 1362-1365 , 1 March 2010

Different phenotypes of polycystic ovary syndrome by Rotterdam criteria are differently steroidogenic but similarly insulin resistant

Presented as a poster at the 62nd Annual Meeting, American Society for Reproductive Medicine, October 21–25, 2006, New Orleans, Louisiana.

  • Yong Wang, Ph.D.

      Affiliations

    • Medical School, Nanjing University, Nanjing, People's Republic of China
    • Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China
    • ,
  • JunWei Qu, M.D.

      Affiliations

    • Medical School, Nanjing University, Nanjing, People's Republic of China
    • Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China
    • ,
  • XiaoKe Wu, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China
    • Corresponding Author InformationReprint requests: Xiaoke Wu, M.D., Ph.D., Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, 150040 China (FAX: +86-451-8213-0094).
    web address
    • ,
  • LiHui Hou, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, People's Republic of China
    • ,
  • Risto Erkkola, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Turku University Central Hospital, Turku, Finland
    • ,
  • Yongyan Wang, M.D.

      Affiliations

    • Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing, People's Republic of China

Received 17 January 2009 ,Revised 30 June 2009 ,Accepted 1 July 2009.

References 

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  3. Ehrmann DA. Polycystic ovary syndrome. N Engl J Med. 2005;352:1223–1236
  4. The Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group 2. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81:19–25
  5. Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale HF, Futterweit W, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab. 2006;91:4237–4245
  6. Wu XK. The concepts of “A tiangui” disorder and phlegm affected “baogong” in traditional Chinese medicine represent the clinical anovulation and pathophysiology in women with polycystic ovary syndrome. [in Chinese] Zhongguo Zongxiyi Jiehe Za Zhi. 2009;29:589–590
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  8. Ke WX, Shan GQ, Hua SY. Different responses of insulin, C-peptide, and testosterone to an oral glucose tolerance test in two groups of women with polycystic ovarian syndrome. Acta Obstet Gynecol Scand. 1996;75:166–169
  9. Wu XK, Zhou SY, Sallinen K, Pollanen P, Erkkola R. Ovarian-adrenal cross-talk in polycystic ovary syndrome: evidence from wedge resection. Eur J Endocrinol. 2000;143:383–388
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  11. Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev. 1997;18:774–800
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  13. Franks S, Mason H, Willis D. Follicular dynamics in the polycystic ovary syndrome. Mol Cell Endocrinol. 2000;163:49–52
  14. Mason HD, Willis DS, Beard RW, Winston RM, Margara R, Franks S. Estradiol production by granulosa cells of normal and polycystic ovaries: relationship to menstrual cycle history and concentrations of gonadotropins and sex steroids in follicular fluid. J Clin Endocrinol Metab. 1994;79:1355–1360
  15. Wachs DS, Coffler MS, Malcom PJ, Chang RJ. Comparison of follicle-stimulating-hormone- stimulated dimeric inhibin and estradiol responses as indicators of granulosa cell function in polycystic ovary syndrome and normal women. J Clin Endocrinol Metab. 2006;91:2920–2925
  16. Webber LJ, Stubbs S, Stark J, Trew GH, Margara R, Hardy K, et al. Formation and early development of follicles in the polycystic ovary. Lancet. 2003;362:1017–1021
  17. Wu X, Sallinen K, Anttila L, Mäkinen M, Luo C, Pöllänen P, et al. Expression of insulin-receptor substrate-1 and −2 in ovaries from women with insulin resistance and from controls. Fertil Steril. 2000;74:564–572
  18. Wu XK, Zhou SY, Liu JX, Pöllänen P, Sallinen K, Mäkinen M, et al. selective Ovarian resistance to insulin signaling in women with polycystic ovary syndrome. Fertil Steril. 2003;80:954–965
  19. Qu J, Wang Y, Wu X, Gao L, Hou L, Erkkola R. Insulin resistance directly contributes to androgenic potential within ovarian theca cells. Fertil Steril. 2009;91:1990–1997
  20. Saleh AM, Khalil HS. Review of nonsurgical and surgical treatment and the role of insulin-sensitizing agents in the management of infertile women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2004;83:614–621
  21. Practice Committee of the American Society for Reproductive Medicine . Use of insulin sensitizing agents in the treatment of polycystic ovary syndrome. Fertil Steril. 2004;82(Suppl 1):S181–S183
  22. La Marca A, Morgante G, Palumbo M, Cianci A, Petraglia F, De Leo V. Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome. Fertil Steril. 2002;78:1234–1239
  23. Koivunen RM, Morin-Papunen LC, Ruokonen A, Tapanainen JS, Martikainen HK. Ovarian steroidogenic response to human chorionic gonadotrophin in obese women with polycystic ovary syndrome: effect of metformin. Hum Reprod. 2001;16:2546–2551
  24. Mansfield R, Galea R, Brincat M, Hole D, Mason H. Metformin has direct effects on human ovarian steroidogenesis. Fertil Steril. 2003;79:956–962
  25. Richardson MC, Ingamells S, Simonis CD, Cameron IT, Sreekumar R, Vijendren A, et al. Stimulation of lactate production in human granulosa cells by metformin and potential involvement of adenosine 5' monophosphate-activated protein kinase. J Clin Endocrinol Metab. 2009;94:670–677

 Y.W. has nothing to disclose. J.Q. has nothing to disclose. X.W. has nothing to disclose. L.H. has nothing to disclose. R.E. has nothing to disclose. Y.W. has nothing to disclose.

 Supported by the National Clinical Research Base of Gynecology in Chinese Medicine, and the Heilongjiang Province Foundation for Outstanding Youths (JC200804).

PII: S0015-0282(09)03476-1

doi: 10.1016/j.fertnstert.2009.07.1678

Fertility and Sterility
Volume 93, Issue 4 , Pages 1362-1365 , 1 March 2010

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