Fertility and Sterility
Volume 93, Issue 7 , Pages 2418-2420, 1 May 2010

Early ovarian hyperstimulation syndrome is completely prevented by gonadotropin releasing-hormone agonist triggering in high-risk oocyte donor cycles: a prospective, luteal-phase follow-up study

Presented at the Annual ESHRE Meeting, Amsterdam, June 28–July 1, 2009.

  • Daniel Bodri, M.D., M.S.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain
    • Universitat Autònoma de Barcelona, Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva, Barcelona, Spain
    • Corresponding Author InformationReprint requests: Daniel Bodri, M.D. M.S., Clínica EUGIN, calle Entença 293-295, 08029 Barcelona, Spain (FAX: +34-93-227-56-05).
    • ,
  • Juan José Guillén, M.D.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain
    • ,
  • Marta Trullenque, M.D.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain
    • ,
  • Katja Schwenn, M.D.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain
    • ,
  • Carolina Esteve, M.D.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain
    • ,
  • Oriol Coll, M.D., Ph.D.

      Affiliations

    • Clínica EUGIN, Barcelona, Spain

Received 19 May 2009; received in revised form 4 July 2009; accepted 11 August 2009. published online 05 October 2009.

In this prospective, follow-up study of 102 high-risk oocyte donors in their luteal phase, we found a complete absence of ovarian hyperstimulation syndrome (no signs of hemoconcentration or ascites) after the donors were triggered with a gonadotropin releasing-hormone (GnRH) agonist. Due to its powerful preventive effect, the GnRH antagonist protocol combined with a GnRH agonist trigger should preferentially be used in egg donors; in conjunction with an effective luteal support or embryo cryopreservation, the protocol could also be applied to high-risk in vitro fertilization patients.

Key Words: GnRH antagonist, GnRH agonist triggering, OHSS, oocyte donation

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 D.B. has nothing to disclose. J.J.G. has nothing to disclose. M.T. has nothing to disclose. K.S. has nothing to disclose. C.E. has nothing to disclose. O.C. has nothing to disclose.

PII: S0015-0282(09)03514-6

doi:10.1016/j.fertnstert.2009.08.036

Fertility and Sterility
Volume 93, Issue 7 , Pages 2418-2420, 1 May 2010

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