Fertility and Sterility
Volume 93, Issue 1 , Pages 268.e15-268.e18 , 1 January 2010

Gene expression during successful implantation in a natural cycle

Presented at the 25th Annual Meeting of the European Society of Human Reproduction and Embryology, Amsterdam, The Netherlands, June 28–July 1, 2009.

  • Inge Van Vaerenbergh, M.Sc.

      Affiliations

    • Department of Pathology, UZ Brussel and Vrije Universiteit Brussel, Jette, Belgium
    • Corresponding Author InformationReprint requests: Inge Van Vaerenbergh, M.Sc., Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium (FAX: =32 2 477 48 09).
    • ,
  • Ramsey McIntire, Ph.D.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, California
    • ,
  • Leentje Van Lommel, M.Sc.

      Affiliations

    • Department of Molecular Cell Biology, Gene Expression Unit, KU Leuven, Leuven, Belgium
    • ,
  • Paul Devroey, M.D., Ph.D.

      Affiliations

    • Centre for Reproductive Medicine, UZ Brussel, Jette, Belgium
    • ,
  • Linda Giudice, M.D., Ph.D., M.Sc.

      Affiliations

    • Department of Obstetrics, Gynecology and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, California
    • ,
  • Claire Bourgain, M.D., Ph.D.

      Affiliations

    • Department of Pathology, UZ Brussel and Vrije Universiteit Brussel, Jette, Belgium

Received 16 June 2009 ,Revised 16 August 2009 ,Accepted 24 August 2009.

References 

  1. Armstrong EM, More IA, McSeveny D, Chatfield WR. Reappraisal of the ultrastructure of the human endometrial glandular cell. J Obstet Gynaecol Br Commonw. 1973;80:446–460
  2. Gordon M. Cyclic changes in the fine structure of the epithelial cells of human endometrium. Int Rev Cytol. 1975;42:127–172
  3. Rosenfeld DL, Garcia CR. Endometrial biopsy in the cycle of conception. Fertil Steril. 1975;26:1088–1093
  4. Balasch J, Vanrell JA, Marquez M, Gonzalez-Merlo J. Endometrial biopsy inadvertently taken in the cycle of conception. Int J Gynaecol Obstet. 1984;22:95–99
  5. Wentz AC, Herbert CM, Maxson WS, Hill GA, Pittaway DE. Cycle of conception endometrial biopsy. Fertil Steril. 1986;46:196–199
  6. Myers ER, Silva S, Barnhart K, Groben PA, Richardson MS, Robboy SJ, et al. Interobserver and intraobserver variability in the histological dating of the endometrium in fertile and infertile women. Fertil Steril. 2004;82:1278–1282
  7. Noyes RW, Hertig AT, Rock J. Dating the endometrial biopsy. Fertil Steril. 1950;1:3–25
  8. Talbi S, Hamilton AE, Vo KC, Tulac S, Overgaard MT, Dosiou C, et al. Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women. Endocrinology. 2006;147:1097–1121
  9. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003;4:249–264
  10. Van Vaerenbergh I, Van Lommel L, Ghislain V, In't Veld P, Schuit F, Fatemi HM, et al. In GnRH antagonist/rec-FSH stimulated cycles, advanced endometrial maturation on the day of oocyte retrieval correlates with altered gene expression. Hum Reprod. 2009;24:1085–1091
  11. Labrie C, Lessard J, Ben Aicha S, Savard MP, Pelletier M, Fournier A, et al. Androgen-regulated transcription factor AIbZIP in prostate cancer. J Steroid Biochem Mol Biol. 2008;108:237–244
  12. Hoshino R, Chatani Y, Yamori T, Tsuruo T, Oka H, Yoshida O, et al. Constitutive activation of the 41-/43-kDa mitogen-activated protein kinase signaling pathway in human tumors. Oncogene. 1999;18:813–822
  13. Rinehart J, Adjei AA, Lorusso PM, Waterhouse D, Hecht JR, Natale RB, et al. Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. J Clin Oncol. 2004;22:4456–4462
  14. Wagner KU, Rui H. Jak2/Stat5 signaling in mammogenesis, breast cancer initiation and progression. J Mammary Gland Biol Neoplasia. 2008;13:93–103
  15. Alpers CE, Davis CL, Barr D, Marsh CL, Hudkins KL. Identification of platelet-derived growth factor A and B chains in human renal vascular rejection. Am J Pathol. 1996;148:439–451
  16. Floege J, Eitner F, Alpers CE. A new look at platelet-derived growth factor in renal disease. J Am Soc Nephrol. 2008;19:12–23
  17. True L, Feng Z. Immunohistochemical validation of expression microarray results. J Mol Diagn. 2005;7:149–151
  18. Fujiwara H, Yoshioka S, Tatsumi K, Kosaka K, Satoh Y, Nishioka Y, et al. Human endometrial epithelial cells express ephrin A1: possible interaction between human blastocysts and endometrium via Eph-ephrin system. J Clin Endocrinol Metab. 2002;87:5801–5807
  19. Fujii H, Tatsumi K, Kosaka K, Yoshioka S, Fujiwara H, Fujii S. Eph-ephrin A system regulates murine blastocyst attachment and spreading. Dev Dynamics. 2006;235:3250–3258
  20. Ihle JN, Kerr IM. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet. 1995;11:69–74
  21. Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, et al. Stage-specific integration of maternal and embryonic PPARδ signaling is critical to pregnancy success. J Biol Chem. 2007;282:37770–37782
  22. Dissen GA, Romero C, Paredes A, Ojeda SR. Neurotrophic control of ovarian development. Microsc Res Tech. 2002;59:509–515
  23. Shibayama E, Koizumi H. Cellular localization of the Trk neurotrophin receptor family in human non-neuronal tissues. Am J Pathol. 1996;148:1807–1818

 I.V.V. has nothing to disclose. R.M. has nothing to disclose. L.V.L. has nothing to disclose. P.D. has received grant support from Merck, Schering Plough, Ferring, IBSA, Besins, Anecova. L.G. is a consultant for Repros Therapeutics, Quest Diagnostics, EMD Serono, Biosante, Vantia Therapeutics, and Bayer Schering Pharma; and owns stock in Pfizer. C.B. has nothing to disclose.

 Supported by grant AL405 from Research Foundation-Flanders (FWO), Belgium, and by National Institute of Child Health and Human Development/National Institutes of Health, Bethesda, MD, through a cooperative agreement U54HD055764-02 (LCG) as part of the Specialized Cooperative Centers Program in Reproduction and Infertility Research.

PII: S0015-0282(09)03596-1

doi: 10.1016/j.fertnstert.2009.08.057

Fertility and Sterility
Volume 93, Issue 1 , Pages 268.e15-268.e18 , 1 January 2010

Article Tools

* Image Usage & Resolution