Fertility and Sterility
Volume 93, Issue 7 , Pages 2453-2455 , 1 May 2010

Robust embryo identification using first polar body single nucleotide polymorphism microarray-based DNA fingerprinting

  • Nathan R. Treff, Ph.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Science, UMDNJ–Robert Wood Johnson Medical School, New Brunswick, New Jersey
    • Corresponding Author InformationReprint requests: Nathan R. Treff, Ph.D., 111 Madison Ave, Suite 100, Morristown, NJ 07960 (FAX: 973-290-8370).
    • ,
  • Jing Su, M.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Natasha Kasabwala, B.A.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Xin Tao, M.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Kathleen A. Miller, B.Sc.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • ,
  • Richard T. Scott Jr., M.D., H.C.L.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology, and Reproductive Science, UMDNJ–Robert Wood Johnson Medical School, New Brunswick, New Jersey

Received 13 July 2009 ,Revised 27 August 2009 ,Accepted 31 August 2009.

References 

  1. Treff NR, Su J, Tao X, Miller KA, Levy B, Scott RT Jr. A novel single-cell DNA fingerprinting method successfully distinguishes sibling human embryos. Fertil Steril. In press.
  2. Chung Y, Bishop CE, Treff NR, Walker SJ, Sandler VM, Becker S, et al. Reprogramming of human somatic cells using human and animal oocytes. Cloning Stem Cells. 2009;11:213–223
  3. Hardy K, Martin KL, Leese HJ, Winston RM, Handyside AH. Human pre-implantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Hum Reprod. 1990;5:708–714
  4. Montag M, van der Ven K, Rösing B, van der Ven H. Polar body biopsy: a viable alternative to preimplantation genetic diagnosis and screening. Reprod Biomed Online. 2009;18(Suppl. 1):6–11
  5. Gitlin S. Oocyte biology and genetics revelations from polar bodies. Reprod Biomed Online. 2003;6:403–409
  6. Di X, Matsuzaki H, Webster TA, Hubbell E, Liu G, Dong S, et al. Dynamic model based algorithms for screening and genotyping over 100 K SNPs on oligonucleotide microarrays. Bioinformatics. 2005;21:1958–1963

 N.R.T., K.A.M., and R.T.S. are supported by grants from EMD Serono, Schering-Plough, Ferring Pharmaceuticals, and Barr Pharmaceuticals. J.S. has nothing to disclose. N.K. has nothing to disclose. X.T. has nothing to disclose.

PII: S0015-0282(09)03624-3

doi: 10.1016/j.fertnstert.2009.08.070

Fertility and Sterility
Volume 93, Issue 7 , Pages 2453-2455 , 1 May 2010

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