Fertility and Sterility
Volume 94, Issue 5 , Pages 1583-1588 , October 2010

Reduced expression and concomitant promoter hypermethylation of HOXA10 in endometrium from women wearing intrauterine devices

  • Yuan Lu, M.D., Ph.D.

      Affiliations

    • Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China
    • ,
  • Jichan Nie, M.D.

      Affiliations

    • Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China
    • ,
  • Xishi Liu, M.D., Ph.D.

      Affiliations

    • Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China
    • ,
  • Sun-Wei Guo, Ph.D.

      Affiliations

    • Renji Hospital, and the Institute of Obstetric and Gynecologic Research, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China
    • Corresponding Author InformationReprint requests: Sun-Wei Guo, Ph.D., Institute of Obstetric and Gynecologic Research, Shanghai Jiao Tong University School of Medicine, Renji Hospital, 145 Shandong Zhong Road, Shanghai 200001, People’s Republic of China (FAX: 86-21-5388-2377).

Received 10 July 2009 ,Revised 7 September 2009 ,Accepted 10 September 2009.

References 

  1. World Health Organization. Intrauterine device (IUD)—worth singing about. Prog Reprod Health Res. 2002;60:1–8
  2. Sivin I, Stern J, Coutinho E, Mattos CE, el Mahgoub S, Diaz S, et al. Prolonged intrauterine contraception: a seven-year randomized study of the levonorgestrel 20 mcg/day (LNg 20) and the Copper T380 Ag IUDS. Contraception. 1991;44:473–480
  3. ESHRE Capri Workshop Group. Intrauterine devices and intrauterine systems. Hum Reprod Update. 2008;14:197–208
  4. Stanford JB, Mikolajczyk RT. Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects. Am J Obstet Gynecol. 2002;187:1699–1708
  5. Cuadros A, Hirsch JG. Copper on intrauterine devices stimulates leukocyte exudation. Science. 1972;175:175–176
  6. Salaverry G, Mendez Mdel C, Zipper J, Medel M. Copper determination and localization in different morphologic components of human endometrium during the menstrual cycle in copper intrauterine contraceptive device wearers. Am J Obstet Gynecol. 1973;115:163–168
  7. Sheppard BL. Endometrial morphological changes in IUD users: a review. Contraception. 1987;36:1–10
  8. Cohen J. Fecundity following IUD use. Author's translation. Contracept Fertil Sex (Paris). 1981;9:465–468
  9. Belhadj H, Sivin I, Diaz S, Pavez M, Tejada AS, Brache V, et al. Recovery of fertility after use of the levonorgestrel 20 mcg/d or Copper T 380 Ag intrauterine device. Contraception. 1986;34:261–267
  10. Gupta BK, Gupta AN, Lyall S. Return of fertility in various types of IUD users. Int J Fertil. 1989;34:123–125
  11. Hata Y, Ishihama A, Kudo N, Nakamura Y, Miyai T, Makino T, et al. The effect of long-term use of intrauterine devices. Int J Fertil. 1969;14:241–249
  12. Horcajadas JA, Sharkey AM, Catalano RD, Sherwin JR, Dominguez F, Burgos LA, et al. Effect of an intrauterine device on the gene expression profile of the endometrium. J Clin Endocrinol Metab. 2006;91:3199–3207
  13. Tetrault AM, Richman SM, Fei X, Taylor HS. Decreased endometrial HOXA10 expression associated with use of the copper intrauterine device. Fertil Steril. 2008;[Epub ahead of print]
  14. Taylor HS. The role of HOX genes in the development and function of the female reproductive tract. Semin Reprod Med. 2000;18:81–89
  15. Taylor HS. The role of HOX genes in human implantation. Hum Reprod Update. 2000;6:75–79
  16. Taylor HS, Bagot C, Kardana A, Olive D, Arici A. HOX gene expression is altered in the endometrium of women with endometriosis. Hum Reprod. 1999;14:1328–1331
  17. Gui Y, Zhang J, Yuan L, Lessey BA. Regulation of HOXA-10 and its expression in normal and abnormal endometrium. Mol Hum Reprod. 1999;5:866–873
  18. Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo SW. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol. 2005;193:371–380
  19. Kim JJ, Taylor HS, Lu Z, Ladhani O, Hastings JM, Jackson KS, et al. Altered expression of HOXA10 in endometriosis: potential role in decidualization. Mol Hum Reprod. 2007;13:323–332
  20. Lee B, Du H, Taylor HS. Experimental murine endometriosis induces DNA methylation and altered gene expression in eutopic endometrium. Biol Reprod. 2009;80:79–85
  21. Rountree MR, Bachman KE, Herman JG, Baylin SB. DNA methylation, chromatin inheritance, and cancer. Oncogene. 2001;20:3156–3165
  22. Shen F, Wang Y, Lu Y, Yuan L, Liu X, Guo SW. Immunoreactivity of progesterone receptor isoform B and nuclear factor kappa-B as biomarkers for recurrence of ovarian endometriomas. Am J Obstet Gynecol. 2008;199:486.e1-486.e10
  23. Ylikorkala O, Siljander M, Huhtaniemi I, Kauppila A, Seppala M. Trophoblastic markers in women using intrauterine contraception. Obstet Gynecol. 1980;55:329–332
  24. Inhaka R, Gentleman RR. R: a language for data analysis and graphics. J Comput Graph Statist. 1996;5:1923–1927
  25. Taylor HS, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. J Clin Invest. 1998;101:1379–1384
  26. Ushijima T, Okochi-Takada E. Aberrant methylations in cancer cells: where do they come from?. Cancer Sci. 2005;96:206–211
  27. Issa JP. Aging, DNA methylation and cancer. Crit Rev Oncol Hematol. 1999;32:31–43
  28. Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res. 2001;61:3573–3577
  29. Hsieh CJ, Klump B, Holzmann K, Borchard F, Gregor M, Porschen R. Hypermethylation of the p16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. Cancer Res. 1998;58:3942–3945
  30. Song JZ, Stirzaker C, Harrison J, Melki JR, Clark SJ. Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells. Oncogene. 2002;21:1048–1061
  31. Stirzaker C, Song JZ, Davidson B, Clark SJ. Transcriptional gene silencing promotes DNA hypermethylation through a sequential change in chromatin modifications in cancer cells. Cancer Res. 2004;64:38717
  32. Kang GH, Lee S, Kim WH, Lee HW, Kim JC, Rhyu MG, et al. Epstein-Barr virus-positive gastric carcinoma demonstrates frequent aberrant methylation of multiple genes and constitutes CpG island methylator phenotype-positive gastric carcinoma. Am J Pathol. 2002;160:787–794
  33. Sandvei R, Wollen AL, Flood PR, Anker C. Mast cells in the tubal wall in women using an intrauterine contraceptive device. Br J Obstet Gynaecol. 1986;93:758–764
  34. Lebovic DI, Bentzien F, Chao VA, Garrett EN, Meng YG, Taylor RN. Induction of an angiogenic phenotype in endometriotic stromal cell cultures by interleukin-1beta. Mol Hum Reprod. 2000;6:269–275
  35. Sarno J, Schatz F, Huang SJ, Lockwood C, Taylor HS. Thrombin and Interleukin-1{beta} Decrease HOX Gene Expression in Human First Trimester Decidual Cells: Implications for Pregnancy Loss. Mol Hum Reprod. 2009;15:451–457
  36. Sivin I, Tatum HJ. Four years of experience with the TCu 380A intrauterine contraceptive device. Fertil Steril. 1981;36:159–163
  37. UNDP/UNFPA/WHO/World Bank. Special Programme of Research, Development and Research Training in Human Reproduction: IUD Research Group. A randomized multicentre trial of the Multiload 375 and TCu380A IUDs in parous women: three-year results. Contraception. 1994;49:543–549
  38. Bhalla KN. Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies. J Clin Oncol. 2005;23:3971–3993

 Y.L. has nothing to disclose. J.N. has nothing to disclose. X.L. has nothing to disclose. S.-W.G. has nothing to disclose.

 Yuan Lu and Jichan Nie contributed equally to this article.

 Supported by grants C03030401/30700903 (Y.L.) and 30872759 (S.-W.G.) from the National Science Foundation of China, and the Pujian Project and grant 074119517 from the Shanghai Science and Technology Commission (S.-W.G.).

PII: S0015-0282(09)03690-5

doi: 10.1016/j.fertnstert.2009.09.011

Fertility and Sterility
Volume 94, Issue 5 , Pages 1583-1588 , October 2010

Article Tools

* Image Usage & Resolution