Fertility and Sterility
Volume 93, Issue 7 , Pages 2415-2417 , 1 May 2010

The efficacy of multiple-dose methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery: a study on 294 cases

Received 10 June 2009 ,Revised 11 August 2009 ,Accepted 8 September 2009.

References 

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  4. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens. Obstet Gynecol. 2003;101:778–784
  5. Habana A, Dokras A, Giraldo JL, Jones EE. Cornual heterotopic pregnancy: contemporary management options. Am J Obstet Gynecol. 2000;182:1264–1270
  6. Bangsgaard N, Lund CO, Ottesen B, Nilas L. Improved fertility following conservative surgical treatment of ectopic pregnancy. BJOG. 2003;110:765–770
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  8. van Mello NM, Mol F, Mol BW, Hajenius PJ. Conservative management of tubal ctopic pregnancy. 2009 Mar 17 [Epub ahead of print].
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  10. Soliman KB, Saleh NM, Omran AA. Safety and efficacy of systemic methotrexate in the treatment of unruptured tubal pregnancy. Saudi Med J. 2006;27:1005–1010
  11. Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Hamed EA. Comparision of success rates in the medical management of ectopic pregnancy with single-dose and multiple-dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril. 2006;85:1661–1666
  12. Srivichai K, Uttavichai C, Tongsong T. Medical treatment of ectopic pregnancy: a ten-year review of 106 cases at Maharaj Nakorn Chiang Mai Hospital. J Med Assoc Thai. 2006;89:1567–1571
  13. Rozenberg P, Chevret S, Camus E, de Tayrac R, Garbin O, de Poncheville L, et al. Medical treatment of ectopic pregnancies: a randomized clinical trial comparing methotrexate-mifepristone and methotrexate-placebo. Hum Reprod. 2003;18:1802–1808
  14. Kirk E, Bourne T. The nonsurgical management of ectopic pregnancy. Curr Opin Obstet Gynecol. 2006;18:587–593
  15. Cho GJ, Lee SH, Shin JW, Lee NW, Kim T, Kim HJ, et al. Predictors of success of repeated injection of single-dose methotreaxate regimen for tubal ectopic pregnancy. J Korean Med Sci. 2006;21:86–89
  16. Menon S, Colins J, Barnhart KT. Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: a systematic review. Fertil Steril. 2007;87:481–484
  17. Moon MH, Lee YH, Lim KT, Yang JH, Park SH. Outcome prediction for treatment of tubal pregnancy using an intramuscular methotrexate protocol. J Ultrasound Med. 2008;27:1461–1467
  18. Potter MB, Lepine LA, Jamieson DJ. Predictors of success with methotrexate treatment of tubal ectopic pregnancy at Grady Memorial Hospital. Am J Obstet Gynecol. 2003;188:1192–1194

 O.B. has nothing to disclose. S.O. has nothing to disclose. A.S.M. has nothing to disclose. A.A. has nothing to disclose. M.C.C. has nothing to disclose.

PII: S0015-0282(09)03693-0

doi: 10.1016/j.fertnstert.2009.09.014

Fertility and Sterility
Volume 93, Issue 7 , Pages 2415-2417 , 1 May 2010

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