Fertility and Sterility
Volume 94, Issue 1 , Pages 384-386 , June 2010

Genotype and haplotype determination of interleukin (IL) 1β (g. −511C>T and g. +3954C>T) and IL-1RN in polycystic ovary syndrome

  • Yan Yang, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China
    • ,
  • Jie Qiao, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China
    • Corresponding Author InformationReprint requests: Jie Qiao, M.D., Department of Obstetrics and Gynecology, Peking University Third Hospital, No. 49 HuaYuan Bei Road, HaiDian District, Beijing, China 100083 (FAX: 86-10-62013283).
    • ,
  • Rong-Xin Tang, M.Sc.

      Affiliations

    • Department of Obstetrics and Gynecology, Lanzhou University First Hospital, Lanzhou, People's Republic of China
    • ,
  • Mei-zhi Li, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, People's Republic of China

Received 10 August 2008 ,Revised 4 September 2009 ,Accepted 18 September 2009.

References 

  1. Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, Escobar-Morreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected caucasian women from Spain. J Clin Endocrinol Metab. 2000;85:2434–2438
  2. Franks S, Gharani N, Waterworth D, Batty S, White D, Williamson R, et al. The genetic basis of polycystic ovary syndrome. Hum Reprod. 1997;12:2641–2648
  3. Luque-Ramirez M, San Millan JL, Escobar-Morreale HF. Genomic variants in polycystic ovary syndrome. Clin Chim Acta. 2006;366:14–26
  4. Dinarello CA. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int Rev Immunol. 1998;16:457–499
  5. Kolbus A, Walch K, Nagele F, Wenzl R, Unfried G, Huber JC. Interleukin-1 alpha but not interleukin-1 beta gene polymorphism is associated with polycystic ovary syndrome. J Reprod Immunol. 2007;73:188–193
  6. Hart R, Hickey M, Franks S. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18:671–683
  7. Yang J, Hu Z, Xu Y, Shen J, Niu J, Hu X, et al. Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population. Cancer Lett. 2004;215:191–198
  8. Buchs N, di Giovine FS, Silvestri T, Vannier E, Duff GW, Miossec P. IL-1β and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels. Genes Immun. 2001;2:222–228
  9. Kolbus A, Walch K, Szabo L, Huber JC, Nagele F, Unfried G. A polymorphism of the interleukin 1 receptor antagonist is not associated with polycystic ovary syndrome in caucasian women. Fertil Steril. 2006;85:523–525

 Y.Y. has nothing to disclose. J.Q. has nothing to disclose. R.-X.T. has nothing to disclose. M.L. has nothing to disclose.

 Supported by National Key Technology R&D Program (2007BA104B00), Beijing, China.

PII: S0015-0282(09)03791-1

doi: 10.1016/j.fertnstert.2009.09.042

Fertility and Sterility
Volume 94, Issue 1 , Pages 384-386 , June 2010

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