Fertility and Sterility
Volume 93, Issue 8 , Pages 2738-2743 , 15 May 2010

Vitamin D3 receptor is expressed in the endometrium of cycling mice throughout the estrous cycle

  • Amir Hassan Zarnani, D.M.T., Ph.D.

      Affiliations

    • Nanobiotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
    • Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  • ,
  • Mehdi Shahbazi, M.S.

      Affiliations

    • Immunology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Alireza Salek-Moghaddam, Ph.D.

      Affiliations

    • Immunology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Mehri Zareie, Ph.D.

      Affiliations

    • Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada
  • ,
  • Maryam Tavakoli, M.D.

      Affiliations

    • Immunology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Jemileh Ghasemi, B.S.

      Affiliations

    • Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  • ,
  • Simin Rezania, M.S.

      Affiliations

    • Department of Microbiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Ali Moravej, M.S.

      Affiliations

    • Immunology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  • ,
  • Ebrahim Torkabadi, M.S.

      Affiliations

    • Reproductive Biotechnology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  • ,
  • Hodjattallah Rabbani, Ph.D.

      Affiliations

    • Immune and Gene Therapy Laboratory, CCK, Department of Oncology-Pathology, Karolinska University Hospital Solna, Stockholm, Sweden
    • Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
  • ,
  • Mahmood Jeddi-Tehrani, Ph.D.

      Affiliations

    • Immune and Gene Therapy Laboratory, CCK, Department of Oncology-Pathology, Karolinska University Hospital Solna, Stockholm, Sweden
    • Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran
    • Corresponding Author InformationReprint requests: Mahmood Jeddi-Tehrani, Ph.D., Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, P.O. Box: 19615-1177, Tehran, Iran (FAX: +98-21-22432021).

Received 19 January 2009 ,Revised 23 September 2009 ,Accepted 23 September 2009.

References 

  1. Jones G, Strugnell SA, DeLuca HF. Current understanding of the molecular actions of vitamin D. Physiol Rev. 1998;78:1193–1231
  2. Chen TL, Feldman D. The effects of 1,25-dihydroxyvitamin D and dexamethasone on rat osteoblast-like primary cell cultures: receptor occupancy and functional expression patterns for three different bioresponses. Endocrinology. 1986;118:250–259
  3. Halloran BP, DeLuca HF. Appearance of the intestinal cytosolic receptor for 1,25-dihydroxyvitamin D3 during neonatal development in the rat. J Biol Chem. 1981;25(256):7338–7342
  4. Gallagher JC, Riggs BL, Eisman J, Hamstra A, Arnaud SB, DeLuca HF. Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest. 1979;64:729–736
  5. Russell JE, Morimoto S, Birge SJ, Fausto A, Avioli LV. Effects of age and estrogen on calcium absorption in the rat. J Bone Miner Res. 1986;1:185–189
  6. Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem Cell Biol. 1996;105:7–15
  7. Van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005;97:93–101
  8. Adorini L, Penna G, Giarratana N, Roncari A, Amuchastegui S, Daniel KC, et al. Dendritic cells as key targets for immunomodulation by vitamin D receptor ligands. J Steroid Biochem Mol Biol. 2004;89–90:437–441
  9. Corbett ST, Hill O, Nangia AK. Vitamin D receptor found in human sperm. Urology. 2006;68:1345–1349
  10. Viganò P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol. 2006;36:415–424
  11. Welsh J, Wietzke JA, Zinser GM, Smyczek S, Romu S, Tribble E, et al. Impact of the Vitamin D3 receptor on growth-regulatory pathways in mammary gland and breast cancer. J Steroid Biochem Mol Biol. 2002;83:85–92
  12. Panda DK, Miao D, Tremblay ML, Sirois J, Farookhi R, Hendy GN, et al. Targeted ablation of the 25-hydroxyvitamin D1a-hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci USA. 2001;98:7498–7503
  13. Yoshizawa T, Handa Y, Uematsu Y, Takeda S, Sekine K, Yoshihara Y, et al. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat Genet. 1997;16:391–396
  14. Kwiecinksi GG, Petrie GI, DeLuca HF. 1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats. Am J Physiol. 1989;256:E483–E487
  15. Zarnani AH, Moazzeni SM, Shokri F, Salehnia M, Dokouhaki P, Ghods R, et al. Microenvironment of the feto-maternal interface protects the semiallogenic fetus through its immunomodulatory activity on dendritic cells. Fertil Steril. 2008;90:781–788
  16. Juretic K, Strbo N, Crncic TB, Laskarin G, Rukavina D. An insight into the dendritic cells at the maternal-fetal interface. Am J Reprod Immunol. 2004;52:350–355
  17. Raghupathy R. Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. Semin Immunol. 2001;13:219–227
  18. Choudhury SR, Knapp LA. Human reproductive failure I: immunological factors. Hum Reprod Update. 2001;7:113–134
  19. Bubanovic I. 1α,25-dihydroxy-vitamin-D3 as new immunotherapy in treatment of recurrent spontaneous abortion. Med Hypotheses. 2004;63:250–253
  20. Zarnani AH, Moazzeni SM, Shokri F, Salehnia M, Jeddi Tehrani M. Analysis of endometrial myeloid and lymphoid dendritic cells during mouse estrous cycle. J Reprod Immunol. 2006;71:28–40
  21. Zarnani AH, Moazzeni SM, Shokri F, Salehnia M, Dokouhaki P, Shojaeian J, et al. The efficient isolation of murine splenic dendritic cells and their cytochemical features. Histochem Cell Biol. 2006;126:275–282
  22. Chan TY. Vitamin D deficiency and susceptibility to tuberculosis. Calcif. Tissue Int. 2000;66:476–478
  23. Liel Y, Shany S, Smirnoff P, Schwartz B. Estrogen increases 1,25-dihydroxyvitamin D receptors expression and bioresponse in the rat duodenal mucosa. Endocrinology. 1999;140:280–285
  24. Gilad LA, Bresler T, Gnainsky J, Smirnoff P, Schwartz B. Regulation of vitamin D receptor expression via estrogen-induced activation of the ERK 1/2 signaling pathway in colon and breast cancer cells. J Endocrinol. 2005;185:577–592
  25. Gilad LA, Tirosh O, Schwartz B. Phytoestrogens regulate transcription and translation of vitamin D receptor in colon cancer cells. J Endocrinol. 2006;191:387–398
  26. Levy J, Zuili I, Yankowitz N, Shany S. Induction of cytosolic receptors for 1 alpha, 25. dihydroxyvitamin D3 in the immature rat uterus by oestradiol. J Endocrinol. 1984;100:265–269
  27. Harris SS, Eccleshall TR, Gross C, Dawson-Hughes B, Feldman D. The vitamin D receptor start codon polymorphism (FokI) and bone mineral density in premenopausal American black and white women. J Bone Miner Res. 1997;12:1043–1048
  28. Gross C, Eccleshall TR, Malloy PJ, Villa ML, Marcus R, Feldman D. The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women. J Bone Miner Res. 1996;11:1850–1855
  29. Correale J, Ysrraelit MC, Gaitán MI. Immunomodulatory effects of vitamin D in multiple sclerosis. Brain. 2009;132:1146–1160
  30. Jeddi-Tehrani M, Abbasi N, Dokouhaki P, Ghasemi J, Rezania S, Ostadkarampour M, et al. Indoleamine 2,3-dioxygenase is expressed in the endometrium of cycling mice throughout the oestrous cycle. J Reprod Immunol. 2009;80:41–48
  31. Robertson SA. Control of the immunological environment of the uterus. Rev Reprod. 2000;5:164–174
  32. Wira CR, Grant-Tschudy KS, Crane-Godreau MA. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am J Reprod Immunol. 2005;53:65–76
  33. Wira CR, Fahey JV, Sentman CL, Pioli PA, Shen L. Innate and adaptive immunity in female genital tract: cellular responses and interactions. Immunol Rev. 2005;206:306–335
  34. Potashnik G, Lunenfeld E, Levitas E, Itskovitz J, Albutiano S, Yankowitz N, et al. The relationship between endogenous oestradiol and vitamin D3 metabolites in serum and follicular fluid during ovarian stimulation for in-vitro fertilization and embryo transfer. Hum Reprod. 1992;7:1357–1360
  35. Hodgins MB, Murad S. 1, 25-Dihydroxycholecalciferol stimulates conversion of androstenedione into oestrone by human skin fibroblasts in culture. J Endocrinol. 1986;110:R1–R4
  36. Erickson GF, Magoffin DA, Cragun JR, Chang RJ. The effects of insulin and insulin-like growth factors-I and -II on estradiol production by granulosa cells of polycystic ovaries. J Clin Endocrinol Metab. 1990;70:894–902
  37. Drummond AE. The role of steroids in follicular growth. Reprod Biol Endocrinol. 2006;4:16
  38. Johnson JA, Kumar R. Renal and intestinal calcium transport: roles of vitamin D and vitamin D-dependent calcium binding proteins. Semin Nephrol. 1994;14:119–128
  39. Audran M, Gross M, Kumar R. The physiology of the vitamin D endocrine system. Semin Nephrol. 1986;6:4–20
  40. Fujimoto G, Tsuchiya H, Kobayashi K, Saga M, Rothman CM, Ogawa S. Calcium concentration and fertilization by subzonal insemination of a single spermatozoon in mouse oocytes. Mol Reprod Dev. 1994;38:54–60

 A.H.Z. has nothing to disclose. M.S. has nothing to disclose. A.S-M. has nothing to disclose. M.Z. has nothing to disclose. M.T. has nothing to disclose. J.G. has nothing to disclose. S.R. has nothing to disclose. A.M. has nothing to disclose. E.T. has nothing to disclose. H.R. has nothing to disclose. M.J-T. has nothing to disclose.

 Funding provided by Avicenna Research Institute, Tehran, Iran.

PII: S0015-0282(09)03795-9

doi: 10.1016/j.fertnstert.2009.09.045

Fertility and Sterility
Volume 93, Issue 8 , Pages 2738-2743 , 15 May 2010