Fertility and Sterility
Volume 93, Issue 8 , Pages 2565-2571 , 15 May 2010

Glial cell line–derived neurotrophic factor (GDNF) and its receptors in human ovaries from fetuses, girls, and women

  • Jacob Farhi, M.D.

      Affiliations

    • Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Asangla Ao, Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
    • Department of Human Genetics, McGill University, Montreal, Quebec, Canada
  • ,
  • Benjamin Fisch, M.D., Ph.D.

      Affiliations

    • Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Xiao Yun Zhang, M.Sc.

      Affiliations

    • Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada
  • ,
  • Roni Garor, M.Sc.

      Affiliations

    • Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  • ,
  • Ronit Abir, Ph.D.

      Affiliations

    • Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel
    • Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    • Corresponding Author InformationReprint requests: Ronit Abir, Ph.D., Infertility and IVF Unit, Helen Schneider Hospital for Women, Rabin Medical Center, Beilinson Hospital, Petach Tikva 49100, Israel (FAX: 972-3-9376641).

Received 30 August 2009 ,Revised 23 September 2009 ,Accepted 23 September 2009.

References 

  1. Loveland KL, Hogarth C, Mendis S, Efthymiadis A, Ly J, Itman C, et al. Drivers of germ cell maturation. Ann N Y Acad Sci. 2005;1061:173–182
  2. Backmana CM, Shan L, Zhang YJ, Hoffer BJ, Leonard S, Troncoso C, et al. Gene expression patterns for GDNF and its receptors in the human putamen affected by Parkinson's disease: a real-time PCR study. Mol Cell Endocrinol. 2006;252:160–166
  3. Wang Y, Geng Z, Zhao L, Huang SH, Sheng AL, Chen ZY. GDNF isoform affects intracellular trafficking and secretion of GDNF in neuronal cells. Brain Res. 2008;1226:1–7
  4. Angrist M, Jing S, Bolk S, Bentley K, Nallasamy S, Halushka M, et al. Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. Genomics. 1998;48:354–362
  5. Sanicola M, Hession C, Worley D, Carmillo P, Ehrenfels C, Walus L, et al. Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins. Proc Natl Acad Sci USA. 1997;94:6238–6243
  6. Shefelbine SE, Khorana S, Schultz PN, Huang E, Thobe N, Hu ZJ, et al. Hum Genet. 1998;102:474–478
  7. Dey BK, Wong YW, Too HP. Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor. NeuroReport. 1998;9:37–42
  8. de Groot JW, Links TP, Plukker JT, Lips CJ, Hofstra RM. RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors. Endocrinol Rev. 2006;27:535–560
  9. Ichihara M, Murakumo Y, Takahashi M. RET and neuroendocrine tumors. Cancer. 2004;204:197–211
  10. de Graaff E, Srinivas S, Kilkenny C, D'Agati V, Mankoo BS, Costantini F, et al. Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 2001;15:2433–2444
  11. Lee DC, Chan KW, Chan SY. RET receptor tyrosine kinase isoforms in kidney function and disease. Oncogene. 2002;21:5582–5592
  12. Lorenzo MJ, Gish GD, Houghton C, Stonehouse TJ, Pawson T, Ponder BA, et al. RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene. 1997;14:763–771
  13. Gougeon A. Regulations of ovarian follicular development in primates: facts and hypotheses. Endocrinol Rev. 1996;17:121–154
  14. Abir R, Nitke S, Ben-Haroush A, Fisch B. In vitro maturation of human primordial ovarian follicles—clinical significance, progress and methods for growth evaluation. Histol Histopathol. 2006;21:887–898
  15. Dole G, Nilsson EE, Skinner MK. Glial derived neurotrophic factor promotes ovarian primordial follicle. Reproduction. 2008;135:671–682
  16. Golden JP, DeMaro JA, Osborne PA, Milbrandt J, Johnson EM. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp Neurol. 1999;158:504–528
  17. Aravindakshan J, Chen XL, Sairam MR. Age-dependent bimodal GDNF regulation during ovarian tumorigenesis in follitropin receptor mutant mice. Biochem Biophys Res Commun. 2006;351:507–513
  18. Pinkas H, Fisch B, Rozansky G, Felz C, Kessler-Icekson G, Krissi H, et al. Platelet-derived growth factors (PDGF-A and -B) and their receptors in human fetal and adult ovaries. Mol Hum Reprod. 2008;14:199–206
  19. Abir R, Fisch B, Jin S, Barnett M, Ben Haroush A, Felz C, et al. Presence of NGF and its receptors in ovaries from human fetuses and adults. Mol Hum Reprod. 2005;11:229–236
  20. Harel S, Jin S, Fisch B, Feldberg D, Krissi H, Freimann S, et al. Tyrosine kinase B receptor and its activated neurotrophins in ovaries from human fetuses and adults. Mol Hum Reprod. 2006;12:357–365
  21. Tsui-Pierchala BA, Ahrens RC, Crowder RJ, Milbrandt J, Johnson EM. The long and short isoforms of Ret function as independent signaling complexes. J Biol Chem. 2002;13(277):34618–34625
  22. Lee KY, Samy ET, Sham MH, Tam PK, Lui VC. 3′ Splicing variants of ret receptor tyrosine kinase are differentially expressed in mouse embryos and in adult mice. Biochim Biophys Acta. 2003;1627:26–38
  23. Choi-Lundberg DL, Bohn MC. Ontogeny and distribution of glial cell line-derived neurotrophic factor (GDNF) mRNA in rat. Brain Res Dev Brain Res. 1995;85:80–88
  24. Kawamura K, Ye Y, Kawamura N, Jing L, Groenen P, Gelpke MS, et al. Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor. Dev Biol. 2008;315:189–202
  25. Widenfalk J, Parvinen M, Lindqvist E. Olson L Neurturin, RET, GFRalpha-1 and GFRalpha-2, but not GFRalpha-3, mRNA are expressed in mice gonads. Cell Tissue Res. 2000;299:409–415
  26. Linher K, Wu D, Li J. Glial cell line-derived neurotrophic factor: an intraovarian factor that enhances oocyte developmental competence in vitro. Endocrinology. 2007;148:4292–4301
  27. Abir R, Garor R, Ao A, Fisch B. In:  MacIntire GK editors. Nerve Growth Factor-New Research Issues. Nerve growth factor in the human ovary. chapter 9:Hauppauge, NY: Nova Science Publishers Inc.; 2008;

 J.F. has nothing to disclose. A.A. has nothing to disclose. B.F. has nothing to disclose. X.Y.Z. has nothing to disclose. R.G. has nothing to disclose. R.A. has nothing to disclose.

PII: S0015-0282(09)03797-2

doi: 10.1016/j.fertnstert.2009.09.047

Fertility and Sterility
Volume 93, Issue 8 , Pages 2565-2571 , 15 May 2010