Fertility and Sterility
Volume 94, Issue 1 , Pages 378-380, June 2010

Unexplained fetal loss: the fetal side of thrombophilia

  • Andrea Luigi Tranquilli, M.D., Ph.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Franca Saccucci, B.Sc.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Stefano Raffaele Giannubilo, M.D., Ph.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • Corresponding Author InformationReprint requests: Stefano R. Giannubilo, M.D., Ph.D., Department of Clinical Sciences, Obstetrics and Gynecology, “G. Salesi” Hospital via F. Corridoni 11 60128 Ancona, Italy (FAX: 0039 71 36575).
    • ,
  • Monia Cecati, Ph.D.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Linda Nocchi, Ph.D.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Sara Lorenzi, M.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Monica Emanuelli, B.Sc.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy

Received 4 June 2009; received in revised form 18 September 2009; accepted 23 September 2009. published online 11 November 2009.

Carrier status of the fetus for factor V polymorphism or double homozygosity for mutant alleles of the PAI-1 4 G/4 G and MTHFR T677 T polymorphisms must be considered risk factors for intrauterine fetal death. The clinical implications of these data need to be addressed in a prospective study to confirm our preliminary data and to answer the question of whether or not double homozygous individuals should be treated with low molecular-weight heparin and/or low-dose aspirin.

Key Words: IUFD, thrombophilia, placenta, MTHFR, PAI-1, factor V, factor H

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 A.L.T. has nothing to disclose. F.S. has nothing to disclose. S.R.G. has nothing to disclose. M.C. has nothing to disclose. L.N. has nothing to disclose. S.L. has nothing to disclose. M.E. has nothing to disclose.

PII: S0015-0282(09)03802-3

doi:10.1016/j.fertnstert.2009.09.052

Fertility and Sterility
Volume 94, Issue 1 , Pages 378-380, June 2010

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