Fertility and Sterility
Volume 94, Issue 1 , Pages 378-380 , June 2010

Unexplained fetal loss: the fetal side of thrombophilia

  • Andrea Luigi Tranquilli, M.D., Ph.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Franca Saccucci, B.Sc.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Stefano Raffaele Giannubilo, M.D., Ph.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • Corresponding Author InformationReprint requests: Stefano R. Giannubilo, M.D., Ph.D., Department of Clinical Sciences, Obstetrics and Gynecology, “G. Salesi” Hospital via F. Corridoni 11 60128 Ancona, Italy (FAX: 0039 71 36575).
    • ,
  • Monia Cecati, Ph.D.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Linda Nocchi, Ph.D.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Sara Lorenzi, M.D.

      Affiliations

    • Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
    • ,
  • Monica Emanuelli, B.Sc.

      Affiliations

    • Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Ancona, Italy

Received 4 June 2009 ,Revised 18 September 2009 ,Accepted 23 September 2009.

References 

  1. Grandone E, Margaglione M, Colaizzo D, D'Andrea G, Cappucci G, Brancaccio V, et al. Genetic susceptibility to pregnancy-related venous thromboembolism: roles of factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677 T mutations. Am J Obstet Gynecol. 1998;179:1324–1328
  2. Bremme KA. Hemostatic changes in pregnancy. Ballieres Best Pract Res Clin Haematol. 2003;16:153–168
  3. Martinelli I, Taioli E, Cetin I, Marinoni A, Gerosa S, Villa MV, et al. Mutations in coagulation factors in women with unexplained late fetal loss. N Engl J Med. 2000;343:1015–1018
  4. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med. 1999;340:9–13
  5. Preston FE, Rosendaal FR, Walker ID, Briët E, Berntorp E, Conard J, et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348:913–916
  6. Gonen R, Lavi N, Attias D, Schliamser L, Borochowitz Z, Toubi E, et al. Absence of association of inherited thrombophilia with unexplained third-trimester intrauterine fetal death. Am J Obstet Gynecol. 2005;192:742–746
  7. Tranquilli AL, Emanuelli M. The thrombophilic fetus. Med Hypotheses. 2006;67:1226–1229
  8. Alonso A, Soto I, Urgelles MF, Corte JR, Rodriguez MJ, Pinto CR. Acquired and inherited thrombophilia in women with unexplained fetal losses. Am J Obstet Gynecol. 2002;187:1337–1342
  9. Pickering W, Marriott K, Regan L. G20210A prothrombin gene mutation: prevalence in recurrent miscarriage population. Clin Appl Thromb Hemost. 2001;7:25–28
  10. Larciprete G, Gioia S, Angelucci PA, Brosio F, Barbati G, Angelucci GP, et al. Single inherited thrombophilias and adverse pregnancy outcomes. J Obstet Gynaecol Res. 2007;33:423–430
  11. Nelen WL, Steegers EA, Eskes TK, Blom HJ. Genetic risk factor unexplained recurrent early pregnancy loss. Lancet. 1997;350:861
  12. Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, Rosenberg IH, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996;93:7–9
  13. Graham CH. Effect of transforming growth factor-beta on the plasminogen activator system in cultured first trimester human cytotrophoblasts. Placenta. 1997;18:137–143
  14. Hu ZY, Liu YX, Liu K, Byrne S, Ny T, Feng Q, et al. Expression of tissue type and urokinase type plasminogen activators as well as plasminogen activator inhibitor type-1 and type-2 in human and rhesus monkey placenta. J Anat. 1999;194:183–195
  15. Paidas MJ, Ku DH, Arkel YS. Screening and management of inherited thrombophilias in the setting of adverse pregnancy outcome. Clin Perinatol. 2004;31:783–805
  16. Jivraj S, Rai R, Underwood J, Regan L. Genetic thrombophilic mutations among couples with recurrent miscarriage. Hum Reprod. 2006;21:1161–1165
  17. Wigglesworth J. Major problems in pathology, perinatal pathology. Vol. 15. London: WB Saunders; 1984;60–1

 A.L.T. has nothing to disclose. F.S. has nothing to disclose. S.R.G. has nothing to disclose. M.C. has nothing to disclose. L.N. has nothing to disclose. S.L. has nothing to disclose. M.E. has nothing to disclose.

PII: S0015-0282(09)03802-3

doi: 10.1016/j.fertnstert.2009.09.052

Fertility and Sterility
Volume 94, Issue 1 , Pages 378-380 , June 2010

Article Tools