Fertility and Sterility
Volume 94, Issue 2 , Pages 764-766 , July 2010

Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study

  • Ikbal Kaygusuz, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Fatih University, Ankara, Turkey
    • ,
  • Nilgun Ozturk Turhan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Fatih University, Ankara, Turkey
    • ,
  • Candan Iltemir Duvan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Fatih University, Ankara, Turkey
    • Corresponding Author InformationReprint requests: Candan Iltemir Duvan, M.D., Fatih University Hospital, Hosdere cad. No. 145, Yukari Ayranci 06540, Ankara, Turkey (FAX: 90-312-441-54-98).
    • ,
  • Cemile Koca, M.D.

      Affiliations

    • Department of Biochemistry, Fatih University, Ankara, Turkey
    • ,
  • Murat Aydin, M.D.

      Affiliations

    • Department of Biochemistry, Fatih University, Ankara, Turkey

Received 14 May 2009 ,Revised 24 September 2009 ,Accepted 27 September 2009.

References 

  1. Mosca L, Manson JE, Sutherland SE, Langer RD, Manolio T, Barrett-Connor E. Cardiovascular disease in women: a statement for healthcare professionals from the American Heart Association. Circulation. 1997;96:2468–2482
  2. Witteman JC, Grobbee DE, Kok FJ, Hofman A, Valkenburg HA. Increased risk of atherosclerosis in women after the menopause. BMJ. 1989;298:642–644
  3. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24:471–476
  4. Boger RH, Bode-Boger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, et al. Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Circulation. 1998;98:1842–1847
  5. Teerlink T, Neele SJ, de Jong S, Netelenbos JC, Stehouwer CD. Oestrogen replacement therapy lowers plasma levels of asymmetrical dimethylarginine in healthy postmenopausal women. Clin Sci (Lond). 2003;105:67–71
  6. Belchetz PE. Hormonal treatment of postmenopausal women. N Engl J Med. 1994;330:1062–1071
  7. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, et al. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med. 2003;349:523–534
  8. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women: Heart and Estrogen/Progestin Replacement Study (HERS) Research Group. JAMA. 1998;280:605–613
  9. Hintze J. NCSS and PASS. Kaysville, Utah: Number Cruncher Statistical Systems; 2001;
  10. Reimann M, Dierkes J, Carlsohn A, Talbot D, Ferrari M, Hallund J, et al. Consumption of soy isoflavones does not affect plasma total homocysteine or asymmetric dimethylarginine concentrations in healthy postmenopausal women. J Nutr. 2006;136:100–105
  11. Hallund J, Tetens I, Bügel S, Tholstrup T, Ferrari M, Teerlink T, et al. Daily consumption for six weeks of a lignan complex isolated from flaxseed does not affect endothelial function in healthy postmenopausal women. J Nutr. 2006;136:2314–2318
  12. Verhoeven MO, Teerlink T, Kenemans P, Zuijdgeest-van Leeuwen SD, van der Mooren MJ. Effects of a supplement containing isoflavones and Actaea racemosa L. on asymmetric dimethylarginine, lipids, and C-reactive protein in menopausal women. Fertil Steril. 2007;87:849–857
  13. Sacks FM, Lichtenstein A, Van Horn L, Harris W, Kris-Etherton P, Winston M. American Heart Association Nutrition Committee. Soy protein, isoflavones, and cardiovascular health: an American Heart Association Science Advisory for professionals from the Nutrition Committee. Circulation. 2006;113:1034–1044
  14. Fang M, Chen D, Yang CS. Dietary polyphenols may affect DNA methylation. J Nutr. 2007;137:223S–228S
  15. Qin LQ, Xu JY, Tezuka H, Wang PY, Hoshi K. Commercial soy milk enhances the development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in rats. In Vivo. 2007;21:667–671
  16. Santell RC, Chang YC, Nair MG, Helferich WG. Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and the hypothalamic/pituitary axis in rats. J Nutr. 1997;127:263–269
  17. Murray MJ, Meyer WR, Lessey BA, Oi RH, DeWire RE, Fritz MA. Soy protein isolate with isoflavones does not prevent estradiol-induced endometrial hyperplasia in postmenopausal women: a pilot trial. Menopause. 2003;10:456–464

 I.K. has nothing to disclose. N.O.T. has nothing to disclose. C.I.D. has nothing to disclose. C.K. has nothing to disclose. M.A. has nothing to disclose.

PII: S0015-0282(09)03807-2

doi: 10.1016/j.fertnstert.2009.09.057

Fertility and Sterility
Volume 94, Issue 2 , Pages 764-766 , July 2010

Article Tools