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The efficiency of progesterone vaginal gel versus intramuscular progesterone for luteal phase supplementation in gonadotropin-releasing hormone antagonist cycles: A prospective clinical trial

Semra Kahraman, M.D.Corresponding Author Informationemail address, S. Hale Karagozoglu, M.D., Guvenc Karlıkaya, M.D.

Received 16 January 2009; received in revised form 29 September 2009; accepted 3 October 2009. published online 24 November 2009.
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We compared the efficiency of progesterone vaginal gel (PVG) with intramuscular progesterone (IMP) supplementation for luteal phase support after in vitro fertilization and embryo transfer in gonadotropin-releasing hormone (GnRH) antagonist cycles. The treatment outcomes were similar for PVG and IMP for luteal support in GnRH-antagonist protocols. With its ease of use, high tolerability by patients, and fewer side effects, PVG can be a successful alternative to IMP.

Istanbul Memorial Hospital IVF and Reproductive Genetics Unit, Istanbul, Turkey

Corresponding Author InformationReprint requests: Semra Kahraman, M.D., Istanbul Memorial Hospital Piyale Pasa Bulvari Okmeydani-Sisli 34385, Istanbul, Turkey (FAX: +90 212 314 66 49).

 S.K. has nothing to disclose. S.H.K. has nothing to disclose. G.K. has nothing to disclose.

PII: S0015-0282(09)03860-6

doi:10.1016/j.fertnstert.2009.10.004