Fertility and Sterility
Volume 94, Issue 5 , Pages 1787-1792 , October 2010

Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome)

  • Louise A. Brinton, Ph.D.

      Affiliations

    • National Cancer Institute, Rockville, Maryland
    • Corresponding Author InformationReprint requests: Louise A. Brinton, Ph.D., 6120 Executive Blvd., Room 5018, Rockville, MD 20852-7234 (TEL: 301-496-1693; FAX: 301-402-0916)
  • ,
  • Kamran S. Moghissi, M.D.

      Affiliations

    • Wayne State University, Detroit, Michigan
  • ,
  • Carolyn L. Westhoff, M.D.

      Affiliations

    • Columbia University, New York, New York
  • ,
  • Emmet J. Lamb, M.D.

      Affiliations

    • Stanford University, Stanford, California
  • ,
  • Bert Scoccia, M.D.

      Affiliations

    • University of Illinois, Chicago, Illinois

Received 24 April 2009 ,Revised 30 September 2009 ,Accepted 7 October 2009.

References 

  1. Eliassen AH, Hankinson SE. Endogenous hormone levels and risk of breast, endometrial and ovarian cancers: prospective studies. Adv Exp Med Biol. 2008;630:148–165
  2. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89:2745–2749
  3. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;83:3078–3082
  4. Legro RS, Myers E. Surrogate end-points or primary outcomes in clinical trials in women with polycystic ovary syndrome?. Hum Reprod. 2004;19:1697–1704
  5. Revised . 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19:41–47
  6. Jafari K, Javaheri G, Ruiz G. Endometrial adenocarcinoma and the Stein-Leventhal syndrome. Obstet Gynecol. 1978;51:97–100
  7. Navaratnarajah R, Pillay OC, Hardiman P. Polycystic ovary syndrome and endometrial cancer. Semin Reprod Med. 2008;26:62–71
  8. Coulam CB, Annegers JF, Kranz JS. Chronic anovulation syndrome and associated neoplasia. Obstet Gynecol. 1983;61:403–407
  9. Escobedo LG, Lee NC, Peterson HB, Wingo PA. Infertility-associated endometrial cancer risk may be limited to specific subgroups of infertile women. Obstet Gynecol. 1991;77:124–128
  10. Iatrakis G, Zervoudis S, Saviolakis A, Troulos M, Antoniou E, Sarantaki A, et al. Women younger than 50 years with endometrial cancer. Eur J Gynaecol Oncol. 2006;27:399–400
  11. Niwa K, Imai A, Hashimoto M, Yokoyama Y, Mori H, Matsuda Y, et al. A case-control study of uterine endometrial cancer of pre- and post-menopausal women. Oncol Rep. 2000;7:89–93
  12. Wild S, Pierpoint T, Jacobs H, McKeigue P. Long-term consequences of polycystic ovary syndrome: results of a 31 year follow-up study. Hum Fertil (Camb). 2000;3:101–105
  13. dos Santos Silva I, Wark PA, McCormack VA, Mayer D, Overton C, Little V, et al. Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort. Br J Cancer. 2009;100:1824–1831
  14. Schildkraut JM, Schwingl PJ, Bastos E, Evanoff A, Hughes C. Epithelial ovarian cancer risk among women with polycystic ovary syndrome. Obstet Gynecol. 1996;88(4 Pt 1):554–559
  15. Anderson KE, Sellers TA, Chen PL, Rich SS, Hong CP, Folsom AR. Association of Stein-Leventhal syndrome with the incidence of postmenopausal breast carcinoma in a large prospective study of women in Iowa. Cancer. 1997;79:494–499
  16. Gammon MD, Thompson WD. Polycystic ovaries and the risk of breast cancer. Am J Epidemiol. 1991;134:818–824
  17. Talamini R, Franceschi S, Favero A, Negri E, Parazzini F, La Vecchia C. Selected medical conditions and risk of breast cancer. Br J Cancer. 1997;75:1699–1703
  18. Pierpoint T, McKeigue PM, Isaacs AJ, Wild SH, Jacobs HS. Mortality of women with polycystic ovary syndrome at long-term follow-up. J Clin Epidemiol. 1998;51:581–586
  19. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, et al. Ovarian cancer risk associated with varying causes of infertility. Fertil Steril. 2004;82:405–414
  20. Breslow NE, Day NE. Statistical methods in cancer research. Lyon, Franch: International Agency for Research on Cancer; 1987;
  21. Althuis MD, Scoccia B, Lamb EJ, Moghissi KS, Westhoff CL, Mabie JE, et al. Melanoma, thyroid, cervical, and colon cancer risk after use of fertility drugs. Am J Obstet Gynecol. 2005;193(3 Pt 1):668–674
  22. Brinton LA, Lamb EJ, Moghissi KS, Scoccia B, Althuis MD, Mabie JE, et al. Ovarian cancer risk after the use of ovulation-stimulating drugs. Obstet Gynecol. 2004;103:1194–1203
  23. Brinton LA, Scoccia B, Moghissi KS, Westhoff CL, Althuis MD, Mabie JE, et al. Breast cancer risk associated with ovulation-stimulating drugs. Hum Reprod. 2004;19:2005–2013
  24. Hart R, Norman R. Polycystic ovarian syndrome—prognosis and outcomes. Best Pract Res Clin Obstet Gynaecol. 2006;20:751–778
  25. Chittenden BG, Fullerton G, Maheshwari A, Bhattacharya S. Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review. Reprod Biomed Online. 2009;19:398–405
  26. Colafranceschi M, Taddei GL, Scarselli G, Branconi F, Tinacci G, Savino L. Clinico-pathological profile of endometrial carcinoma in young women (under 40 years of age). Eur J Gynaecol Oncol. 1989;10:353–356
  27. Gadducci A, Gargini A, Palla E, Fanucchi A, Genazzani AR. Polycystic ovary syndrome and gynecological cancers: is there a link?. Gynecol Endocrinol. 2005;20:200–208
  28. Gallup DG, Stock RJ. Adenocarcinoma of the endometrium in women 40 years of age or younger. Obstet Gynecol. 1984;64:417–420
  29. Honore LH, Davey SJ. Endometrial carcinoma in young women. A report of four cases. J Reprod Med. 1989;34:845–849
  30. Konishi I, Koshiyama M, Mandai M, Kuroda H, Yamamoto S, Nanbu K, et al. Increased expression of LH/hCG receptors in endometrial hyperplasia and carcinoma in anovulatory women. Gynecol Oncol. 1997;65:273–280
  31. Pillay OC, Te Fong LF, Crow JC, Benjamin E, Mould T, Atiomo W, et al. The association between polycystic ovaries and endometrial cancer. Hum Reprod. 2006;21:924–929
  32. Shu XO, Brinton LA, Zheng W, Gao YT, Fan J, Fraumeni JF. A population-based case-control study of endometrial cancer in Shanghai. China. Int J Cancer. 1991;49:38–43
  33. Kaaks R, Lukanova A, Kurzer MS. Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review. Cancer Epidemiol Biomarkers Prev. 2002;11:1531–1543
  34. Baron JA, Weiderpass E, Newcomb PA, Stampfer M, Titus-Ernstoff L, Egan KM, et al. Metabolic disorders and breast cancer risk (United States). Cancer Causes Control. 2001;12:875–880
  35. Donesky BW, Adashi EY. Surgically induced ovulation in the polycystic ovary syndrome: wedge resection revisited in the age of laparoscopy. Fertil Steril. 1995;63:439–463
  36. Risch HA. Hormonal etiology of epithelial ovarian cancer, with a hypothesis concerning the role of androgens and progesterone. J Natl Cancer Inst. 1998;90:1774–1786
  37. Wynder EL, Dodo H, Barber HR. Epidemiology of cancer of the ovary. Cancer. 1969;23:352–370
  38. Olsen CM, Green A, Nagle C, Jordan S, Whiteman D, Bain C, et al. Epithelial ovarian cancer: testing the androgens hypothesis. Endocr Relat Cancer. 2008;15:1061–1068

 L.A.B. has nothing to disclose. K.S.M. has nothing to disclose. C.L.W. has nothing to disclose. E.J.L. has nothing to disclose. B.S. has nothing to disclose.

 Supported by funds from the intramural research program of the National Cancer Institute, National Institutes of Health.

PII: S0015-0282(09)03872-2

doi: 10.1016/j.fertnstert.2009.10.012

Fertility and Sterility
Volume 94, Issue 5 , Pages 1787-1792 , October 2010