Fertility and Sterility
Volume 94, Issue 2 , Pages 781-783.e1 , July 2010

Epigenetics in polycystic ovary syndrome: a pilot study of global DNA methylation

  • Ning Xu, M.D., Ph.D.

      Affiliations

    • Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    • ,
  • Ricardo Azziz, M.D., M.B.A., M.P.H.

      Affiliations

    • Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • Department of Obstetrics and Gynecology, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • ,
  • Mark O. Goodarzi, M.D., Ph.D.

      Affiliations

    • Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California
    • Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California
    • Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California
    • Corresponding Author InformationReprint requests: Mark O. Goodarzi, M.D., Ph.D., Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Room B-131, Los Angeles, California 90048 (FAX: 310-423-0440).

Received 21 August 2009 ,Revised 8 October 2009 ,Accepted 12 October 2009.

References 

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  2. Shaw LM, Elton S. Polycystic ovary syndrome: a transgenerational evolutionary adaptation. Br J Obstet Gynecol. 2008;115:144–148
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  9. Homburg R. Androgen circle of polycystic ovary syndrome. Hum Reprod. 2009;24:1548–1555
  10. Li Z, Huang H. Epigenetic abnormality: a possible mechanism underlying the fetal origin of polycystic ovary syndrome. Med Hypoth. 2008;70:638–642
  11. Martin-Gronert MS, Ozanne SE. Programming of appetite and type 2 diabetes. Early Hum Dev. 2005;81:981–988
  12. Ho SM, Tang WY, Belmonte de Frausto J, Prins GS. Developmental exposure to estradiol and bisphenol A increases susceptibility to prostate carcinogenesis and epigenetically regulates phosphodiesterase type 4 variant 4. Cancer Res. 2006;66:5624–5632
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  14. Shah NA, Antoine HJ, Pall M, Taylor KD, Azziz R, Goodarzi MO. Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome. J Clin Endocrinol Metab. 2008;93:1939–1945
  15. Hickey T, Chandy A, Norman RJ. The androgen receptor CAG repeat polymorphism and X-chromosome inactivation in Australian Caucasian women with infertility related to polycystic ovary syndrome. J Clin Endocrinol Metab. 2002;87:161–165
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  19. Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89:2745–2749
  20. Zawadzki JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In:  Dunaif A,  Givens JR,  Haseltine F,  Merriam GR editor. Polycystic Ovary Syndrome. Cambridge: Blackwell Scientific Publications; 1992;p. 377–384
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  22. Song F, Mahmood S, Ghosh S, Liang P, Smiraglia DJ, Nagase H, et al. Tissue specific differentially methylated regions (TDMR): changes in DNA methylation during development. Genomics. 2009;93:130–139
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  24. Shimabukuro M, Sasaki T, Imamura A, Tsujita T, Fuke C, Umekage T, et al. Global hypomethylation of peripheral leukocyte DNA in male patients with schizophrenia: a potential link between epigenetics and schizophrenia. J Psychiatr Res. 2007;41:1042–1046

 N.X. has nothing to disclose. R.A. has nothing to disclose. M.O.G. has nothing to disclose.

 This study was supported in part by National Institutes of Health grant nos. R01-HD29364 and K24-HD01346 (to RA), R01-DK79888 (to MOG), and M01-RR00425 (General Clinical Research Center Grant from the National Center for Research Resources [NCRR]); the Cedars-Sinai Winnick Clinical Scholars Award (to MOG) and an endowment from the Helping Hand of Los Angeles, Inc.

PII: S0015-0282(09)03882-5

doi: 10.1016/j.fertnstert.2009.10.020

Fertility and Sterility
Volume 94, Issue 2 , Pages 781-783.e1 , July 2010

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