Fertility and Sterility
Volume 93, Issue 6 , Pages 2075.e11-2075.e15 , April 2010

Two cases of myomectomy complicated by intravascular hemolysis and renal failure: disseminated intravascular coagulation or hemolytic uremic syndrome?

  • Ioannis Tsimpanakos, M.D.

      Affiliations

    • Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, Royal Free Hospital, Hampstead, London, United Kingdom
    • ,
  • John Connolly, Ph.D.

      Affiliations

    • Department of Nephrology, Royal Free Hospital, Hampstead, London, United Kingdom
    • ,
  • Kyriaki S. Alatzoglou, M.Sc.

      Affiliations

    • UCL Institute of Child Health, London, United Kingdom
    • ,
  • Camilla Rowan, M.B., B.S., B.Sc.

      Affiliations

    • Department of Histopathology, Royal Free Hospital, Hampstead, London, United Kingdom
    • ,
  • Adam Magos, M.D., B.Sc., M.B., B.S.

      Affiliations

    • Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, Royal Free Hospital, Hampstead, London, United Kingdom
    • Corresponding Author InformationReprint requests: Adam Magos, B.Sc., M.B., B.S., M.D., FRCOG, Minimally Invasive Therapy Unit and Endoscopy Training Centre, University Department of Obstetrics and Gynaecology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK (FAX: + 44 (0) 20 7431 1321).

Received 31 August 2009 ,Revised 9 November 2009 ,Accepted 10 November 2009.

References 

  1. Jacobson GF, Shaber RE, Armstrong MA, Hung Y-Y. Changes in rates of hysterectomy and uterine conserving procedures for treatment of uterine leiomyoma. Am J Obstet Gynecol. 2007;196:601.e1–601.e5
  2. Data from the National Uterine Fibroids Foundation. Available at www.nuff.org
  3. In-patient data for 2005–06. Hospital Episode Statistics, Department of Health, London, England. Available at http://www.hesonline.nhs.uk
  4. Taylor A, Sharma M, Tsirkas P, Di Spiezio Sardo A, Setchell M, Magos A. Reducing blood loss at open myomectomy using triple tourniquets: a randomized controlled trial. BJOG. 2005;112:340–345
  5. Kongnyuy EJ, Wiysonge CSU. Interventions to reduce haemorrhage during myomectomy for fibroids. Cochrane Database Syst Rev. 2007;1:CD005355
  6. Dalainas I. Pathogenesis, diagnosis and management of disseminated intravascular coagulation: a literature review. Eur Rev Med Pharmacol Sci. 2008;12:19–31
  7. Marshall JC. Inflammation, coagulopathy, and the pathogenesis of multiple organ dysfunction syndrome. Crit Care Med. 2001;29(Suppl 1):S99–S106
  8. Kumar KV, Jensen CE, Singer A, Wonke B, Morgan H. A case of myomectomy complicated by disseminated intravascular coagulation. J Obstet Gynaecol. 1997;17:307–308
  9. Bravo JJ, Novoa D, Romero R, Sanchez-Guisande D. Sindrome hemolitico uremico postmiomectomia. Nefrologia. 2001;21:217
  10. Taylor A, Sharma M, Buck L, Mastrogamvrakis G, Di Spezio Sardo A, Magos A. The use of triple tourniquets for laparoscopic myomectomy. J Gynecol Surg. 2005;21:65–72
  11. Zheng XL, Sadler JE. Pathogenesis of thrombotic microangiopathies. Annu Rev Pathol Mech Dis. 2008;3:249–277
  12. Levi M, Ten Cate H. Disseminated intravascular coagulation. N Engl J Med. 1999;341:586–592
  13. Levi M. Disseminated Intravascular coagulation. Crit Care Med. 2007;35:2191–2195
  14. Levi M, De Jonge E, Van der Poll T, Ten Cate H. Advances in the understanding of the pathogenetic pathways of disseminated intravascular coagulation result in more insight in the clinical picture and better management strategies. Semin Thromb Hemost. 2001;27:569–575
  15. Dempfle CE. The use of soluble fibrin in evaluating the acute and chronic hypercoagulable state. Thromb Haemost. 1999;82:673–683
  16. Taylor FBJ, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost. 2001;86:1327–1330
  17. Mannucci PM. Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome: much progress and many remaining issues. Haematologica. 2007;92:878–880
  18. Tsai HM. The molecular biology of thrombotic microangiopathy. Kidney Int. 2006;70:16–23
  19. Desch K, Motto D. Is there a shared pathophysiology for thrombotic thrombocytopenic purpura and hemolytic uremic syndrome?. J Am Soc Nephrol. 2007;18:2457–2460

 I.T. has nothing to disclose. J.C. has nothing to disclose. K.S.A. has nothing to disclose. C.R. has nothing to disclose. A.M. has nothing to disclose.

PII: S0015-0282(09)04052-7

doi: 10.1016/j.fertnstert.2009.11.023

Fertility and Sterility
Volume 93, Issue 6 , Pages 2075.e11-2075.e15 , April 2010

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