Inhibition of cell proliferation, adhesion, and invasion with an anti-L1-cell adhesion molecule monoclonal antibody in an in vitro endometriosis model
Received 15 September 2009; received in revised form 14 November 2009; accepted 25 November 2009. published online 04 February 2010. Corrected Proof
The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the adhesion compared with unspecific IgG-Ab treated and untreated cells. Because it increases the cell invasion and adhesion which consequently aggravates the disease, L1 could possibly promote endometriosis development; thus, further studies should evaluate the possible use of anti-L1-mAb in an animal endometriosis model.
aDepartment of Obstetrics and Gynecology, University of Schleswig-Holstein, Campus Luebeck
bInstitute of Anthropology and Human Genetics for Biologists, Johann-Wolfgang-Goethe University of Frankfurt, Frankfurt
cTumorimmunology Program, German Cancer Research Center, Heidelberg, Germany
Reprint requests: Daniela Hornung, M.D., Ph.D., Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538 Luebeck, Germany (FAX: +49-451-500-2139).
A.A. has nothing to disclose. U.v.W. has nothing to disclose. A.S-P. has nothing to disclose. K.D. has nothing to disclose. P.A. has nothing to disclose. D.H. has nothing to disclose.
ABSTRACT