Fertility and Sterility
Volume 93, Issue 7 , Pages 2414.e1-2414.e3 , 1 May 2010

Thyroxine replacement during super-ovulation for in vitro fertilization: a potential gap in management?

  • Bronwyn G.A. Stuckey, M.B.B.S., F.R.A.C.P.

      Affiliations

    • Keogh Institute for Medical Research, Nedlands, Western Australia, Australia
    • Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
    • School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia
    • Corresponding Author InformationReprint requests: Bronwyn G. A. Stuckey, Keogh Institute for Medical Research, 3rd floor, A Block, Sir Charles Gairdner Hospital, Nedlands, WA, Australia 6009 (TEL: +61-8-9346-2008; FAX: +61-8-9346-3003).
    • ,
  • Doreen Yeap, M.B.B.S., F.R.A.N.Z.C.O.G.

      Affiliations

    • Fertility Specialists of Western Australia, Claremont, Western Australia, Australia
    • ,
  • Simon R. Turner, M.B.B.S., F.R.A.N.Z.C.O.G.

      Affiliations

    • Hollywood Fertility Centre, Nedlands, Western Australia, Australia

Received 28 September 2009 ,Revised 28 October 2009 ,Accepted 4 November 2009.

References 

  1. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2007;92(Suppl 8):S1–47
  2. Poppe K, Velkeniers B, Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nat Clin Pract Endocrinol Metab. 2008;4:394–405
  3. Gilbert RM, Hadlow NC, Walsh JP, Fletcher SJ, Brown SJ, Stuckey BGA, et al. Assessment of thyroid function during pregnancy: first-trimester (weeks 9-13) reference intervals derived from Western Australian women. Med J Austr. 2008;189:250–253
  4. Glinoer D, Gershengorn MC, Dubois A, Robbins J. Stimulation of thyroxine-binding globulin synthesis by isolated rhesus monkey hepatocytes after in vivo beta-estradiol administration. Endocrinology. 1977;100:807–813
  5. Glinoer D, McGuire RA, Gershengorn MC, Robbins J, Berman M. Effects of estrogen on thyroxine-binding globulin metabolism in rhesus monkeys. Endocrinology. 1977;100:9–17
  6. Poppe K, Velkeniers B, Glinoer D. Thyroid disease and female reproduction. Clin Endocrinol. 2007;66:309–321
  7. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev. 1997;18:404–433
  8. Arafah BM. Increased need for thyroxine in women with hypothyroidism during estrogen therapy. New Engl J Med. 2001;344:1743–1749
  9. Macklon NS, Stouffer RL, Giudice LC, Fauser BC. The science behind 25 years of ovarian stimulation for in vitro fertilization. Endocr Rev. 2006;27:170–207
  10. Muller AF, Verhoeff A, Mantel MJ, De Jong FH, Berghout A. Decrease of free thyroxine levels after controlled ovarian hyperstimulation. J Clin Endocrinol Metab. 2000;85:545–548
  11. Poppe K, Glinoer D, Tournaye H, Schiettecatte J, Devroey P, van Steirteghem A, et al. Impact of ovarian hyperstimulation on thyroid function in women with and without thyroid autoimmunity. J Clin Endocrinol Metab. 2004;89:3808–3812
  12. Poppe K, Glinoer D, Tournaye H, Devroey P, Velkeniers B. Impact of the ovarian hyperstimulation syndrome on thyroid function. Thyroid. 2008;18:801–802
  13. Negro R, Mangieri T, Coppola L, Presicce G, Casavola EC, Gismondi R, et al. Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study. Hum Reprod. 2005;20:1529–1533
  14. Rotondi M, Mazziotti G, Sorvillo F, Piscopo M, Cioffi M, Amato G, et al. Effects of increased thyroxine dosage pre-conception on thyroid function during early pregnancy. Eur J Endocrinol. 2004;151:695–700
  15. Casey BM, Dashe JS, Wells CE, McIntire DD, Leveno KJ, Cunningham FG. Subclinical hyperthyroidism and pregnancy outcomes. Obstet Gynecol. 2006;107:337–341

 B.G.A.S. has nothing to disclose. D.Y. has nothing to disclose. S.R.T. has nothing to disclose.

PII: S0015-0282(09)04143-0

doi: 10.1016/j.fertnstert.2009.11.051

Fertility and Sterility
Volume 93, Issue 7 , Pages 2414.e1-2414.e3 , 1 May 2010

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