Fertility and Sterility
Volume 94, Issue 5 , Pages 1680-1683 , October 2010

Blastocyst versus cleavage stage transfer in in vitro fertilization: differences in neonatal outcome?

  • Bengt Källén, M.D., Ph.D.

      Affiliations

    • Tornblad Institute, University of Lund, Lund, Sweden
    • Corresponding Author InformationReprint requests: Bengt Källén, M.D., Ph.D., Tornblad Institute, Biskopsgatan 7, SE-223 62 Lund, Sweden (TEL: +46-46-222-7536; FAX: +46-46-222-4223).
    • ,
  • Orvar Finnström, M.D., Ph.D.

      Affiliations

    • Department of Paediatrics, University Hospital, Linköping, Sweden
    • ,
  • Anna Lindam, M.Sc.

      Affiliations

    • Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden
    • ,
  • Emma Nilsson, Ph.D.

      Affiliations

    • Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden
    • ,
  • Karl-Gösta Nygren, M.D., Ph.D.

      Affiliations

    • IVF and Fertility Clinic, Sophiahemmet, Stockholm, Sweden
    • ,
  • Petra Otterblad Olausson, Ph.D.

      Affiliations

    • Centre for Epidemiology, National Board of Health and Welfare, Stockholm, Sweden

Received 13 October 2009 ,Revised 7 December 2009 ,Accepted 7 December 2009.

References 

  1. Blake D, Farquhar C, Johnson N, Proctor M. Cleavage stage versus blastocyst stage embryo transfer in assisted conception (Review). Cochrane Data base of Systematic reviews 2007, (Issue 4). Art. No: CD002118. DOI: 10.1002/14651858.CD002118.pub3.
  2. Papanikolaou EG, Kolibianakis EM, Tournaye H, Venetis CA, Fatemi H, Tarlatzis B, et al. Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis. Hum Reprod. 2008;23:91–99
  3. Guerif F, Lemseffer M, Bidault R, Gasnier O, Saussereau H, Cadoret V, et al. Single day 2 embryo versus blastocyst-stage transfer: a prospective study integrating fresh and frozen embryo transfers. Hum Reprod. 2009;24:1051–1058
  4. Millki AA, Jun SH, Hinckley MD, Behr B, Giudice LC, Westphal LM. Incidence of monozygotic twinning with blastocyst transfer compared to cleavage-stage transfer. Fertil Steril. 2003;79:503–506
  5. Chang HJ, Lee JR, Jee BC, Suh CS, Kim SH. Impact of blastocyst transfer on offspring sex ratio and the monozygotic twinning rate: a systematic review and meta-analysis. Fertil Steril. 2009;91:2381–2390
  6. Mercader A, Garcia-Velasco JA, Escudero A, Remohí A, Simón C. Clinical experience and perinatal outcome of blastocyst transfer after coculture of human embryos with human endometrial epithelial cells: a 5-year follow-up study. Fertil Steril. 2003;80:1162–1168
  7. National Board of Health and Welfare. Centre for Epidemiology. The Swedish Medical Birth Register—a summary of content and quality. Available at: http://www.socialstyrelsen.se/Publikationer2003/2003-112-3. Accessed September 23, 2009.
  8. Källén B. A birth weight for gestational age standard based on data in the Swedish medical birth registry 1985-1989. Eur J Epidemiol. 1995;11:601–606
  9. National Board of Health and Welfare. Centre for Epidemiology. Registration of congenital malformations in Swedish health registers. Available at: http://www.socialstyrelsen.se/Publikationer2004/2004-112-1. Accessed September 23, 2009.
  10. Schwärzler P, Zech H, Auer M, Pfau K, Göbel G, Vanderswalmen P, et al. Pregnancy outcome after blastocyst transfer as compared to early cleavage stage embryo transfer. Hum Reprod. 2004;19:2097–2102

 Supported by a grant from Evy and Gunnar Sandberg Foundation, Lund, Sweden, to B.K.

 B.K. has nothing to disclose. O.F. has nothing to disclose. A.L. has nothing to disclose. E.N. has nothing to disclose. K.-G.N. has nothing to disclose. O.P.O. has nothing to disclose.

PII: S0015-0282(09)04213-7

doi: 10.1016/j.fertnstert.2009.12.027

Fertility and Sterility
Volume 94, Issue 5 , Pages 1680-1683 , October 2010

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