Fertility and Sterility
Volume 94, Issue 2 , Pages 753.e1-753.e3 , July 2010

Successful pregnancy by insemination of spermatozoa in a woman with a human seminal plasma allergy: should in vitro fertilization be considered first?

  • Cynthia Frapsauce, M.D.

      Affiliations

    • Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • Corresponding Author InformationReprint requests: Cynthia Frapsauce, M.D., APHP Tenon Hospital, 4, rue de la Chine, 75020 Paris, France (FAX: 331-56-01-78-03).
    • ,
  • Isabelle Berthaut, M.D, Ph.D.

      Affiliations

    • Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Vanina de Larouziere, M.D.

      Affiliations

    • Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Emmanuelle Mathieu d'Argent, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Jean-Eric Autegarden, M.D.

      Affiliations

    • Department of Allergology, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Hanene Elloumi, M.D.

      Affiliations

    • Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Jean-Marie Antoine, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France
    • ,
  • Jacqueline Mandelbaum, M.D., Ph.D.

      Affiliations

    • Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France

Received 4 November 2009 ,Revised 7 January 2010 ,Accepted 11 January 2010.

References 

  1. Bernstein JA, Sugumaran R, Bernstein DI, Bernstein IL. Prevalence of human seminal plasma hypersensitivity among symptomatic women. Ann Allergy Asthma Immunol. 1997;78(1):54–58
  2. Shah A, Panjabi C. Human seminal plasma allergy: a review of a rare phenomenon. Clin Exp Allergy. 2004;34:827–838
  3. Specken J. Een merkwaardig geval van allerie in de gynaecol. Ned Tjidschr Verloskd Gynaecol. 1958;58:314–318
  4. World Health Organization . Laboratory manual for the examination of human semen and sperm–cervical mucus interaction. 4th ed.. New York: Cambridge University Press; 1999;19–71
  5. European Academy of Allergology and Clinical Immunology . Position paper: allergen standardization and skin tests. Allergy. 1993;48:48–82
  6. Halpern B, Ky T, Robert B. Clinical and immunological study of an exceptional case of reaginic type sensitization to human seminal fluid. Immunology. 1967;12:247–258
  7. Frankland AW. Allergy: immunity gone wrong. Proc R Soc Med. 1973;66:365–368
  8. Berger H. Allergy to human semen. NY State J Med. 1975;75:1072–1073
  9. Ebo DG, Stevens WJ, Bridts CH, De Clerck LS. Human seminal plasma anaphylaxis (HSPA): case report and literature review. Allergy. 1995;50:747–750
  10. Levine B, Siraganian R, Schenkein I. Allergy to human seminal plasma. N Engl J Med. 1973;288:894–896
  11. Mittman RJ, Bernstein DI, Alder TR, Korbee L, Nath V, Gallagher JS, et al. Selective desensitization to seminal plasma protein fractions after immunotherapy for postcoïtal anaphylaxis. J Allergy Clin Immunol. 1990;86:954–960
  12. Mike N, Bird G, Asquith P. A new manifestation of seminal fluid hypersensitivity. Q J Med. 1990;75:371–376
  13. Bernstein IL, Englander BE, Gallagher JS, Friedman SA, Nathan P, Marcus ZH. Localized and systemic hypersensitivity reaction to human seminal fluid. Ann Intern Med. 1981;94:459–465
  14. Shapiro SS, Kooistra JB, Schwartz D, Yunginger JW, Haning RV. Induction of pregnancy in a woman with seminal plasma allergy. Fertil Steril. 1981;36:405–407
  15. Iwahashi K, Miyazaki T, Yoshimura Y. Successful pregnancy in a woman with a human seminal plasma allergy. A case report. Reprod Med. 1999;44:391–393
  16. Ferre-Ybarz L, Basagana M, Coroleu B, Bartolome B, Cistero-Bahima A. Human seminal plasma allergy and successful pregnancy. J Investig Allergol Clin Immunol. 2006;16:314–316

 C.F. has nothing to disclose. I.B. has nothing to disclose. V.d.L. has nothing to disclose. E.M.d'A. has nothing to disclose. J.-E.A. has nothing to disclose. H.E. has nothing to disclose. J.-M.A. has nothing to disclose. J.M. has nothing to disclose.

PII: S0015-0282(10)00077-4

doi: 10.1016/j.fertnstert.2010.01.017

Fertility and Sterility
Volume 94, Issue 2 , Pages 753.e1-753.e3 , July 2010

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