Fertility and Sterility
Volume 93, Issue 8 , Pages 2608-2614 , 15 May 2010

Abnormally up-regulated cystic fibrosis transmembrane conductance regulator expression and uterine fluid accumulation contribute to Chlamydia trachomatis-induced female infertility

Received 6 November 2009 ,Revised 11 January 2010 ,Accepted 14 January 2010.

References 

  1. Walters MD, Eddy CA, Gibbs RS, Schachter J, Holden AE, Pauerstein CJ. Antibodies to Chlamydia trachomatis and risk for tubal pregnancy. Am J Obstet Gynecol. 1988;159:942–946
  2. Cates W, Wasserheit JN. Genital chlamydial infections: epidemiology and reproductive sequelae. Am J Obstet Gynecol. 1991;164:1771–1781
  3. Rhoton-Vlasak A. Infections and infertility. Prim Care Update Ob Gyns. 2000;7:200–206
  4. Zana J, Thomas D, Muffat-Joly M, de Brux J, Pocidalo JJ, Orfila J, et al. An experimental model for salpingitis due to Chlamydia trachomatis and residual tubal infertility in the mouse. Hum Reprod. 1990;5:274–278
  5. Jones RB, Mammel JB, Shepard MK, Fisher RR. Recovery of Chlamydia trachomatis from the endometrium of women at risk for chlamydial infection. Am J Obstet Gynecol. 1986;155:35–39
  6. Belshe RB, Mendelman PM, Treanor J, King J, Gruber WC, Piedra P, et al. The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenza virus vaccine in children. N Engl J Med. 1998;338:1405–1412
  7. Glezen WP. Influenza virus in pediatric patients. Introduction. Semin Pediatr Infect Dis. 2002;13:69–70
  8. Doyle WJ, Skoner DP, Hayden F, Buchman CA, Seroky JT, Fireman P. Nasal and otologic effects of experimental influenza A virus infection. Ann Otol Rhinol Laryngol. 1994;103:59–69
  9. Evans HM, Long JA. Characteristic effects upon growth, oestrus and ovulation induced by the intraperitoneal administration of fresh anterior hypophyseal substance. Proc Natl Acad Sci U S A. 1922;8:38–39
  10. Chan LN, Tsang LL, Rowlands DK, Rochelle LG, Boucher RC, Liu CQ, et al. Distribution and regulation of ENaC subunit and CFTR mRNA expression in murine female reproductive tract. J Membr Biol. 2002;185:165–176
  11. Chan LN, Wang XF, Tsang LL, So SC, Chung YW, Liu CQ, et al. Inhibition of amiloride-sensitive Na(+) absorption by activation of CFTR in mouse endometrial epithelium. Pflugers Arch. 2001;443(Suppl. 1):S132–S136
  12. Ismailov II, Berdiev BK, Shlyonsky VG, Fuller CM, Prat AG, Jovov B, et al. Role of actin in regulation of epithelial sodium channels by CFTR. Am J Physiol. 1997;272:C1077–C1086
  13. Ajonuma LC, He Q, Sheung Chan PK, Yu Ng EH, Fok KL, Chan HC, et al. Involvement of cystic fibrosis transmembrane conductance regulator in infection-induced edema. Cell Biol Int. 2008;32:801–806
  14. Bobo L, Novak N, Mkocha H, Vitale S, West S, Quinn TC. Evidence for a predominant proinflammatory conjunctival cytokine response in individuals with trachoma. Infect Immun. 1996;64:3273–3279
  15. Conway DJ, Holland MJ, Bailey RL, Campbell AE, Mahdi OS, Jennings R, et al. Scarring trachoma is associated with polymorphism in the tumor necrosis factor alpha (TNF-alpha) gene promoter and with elevated TNF-alpha levels in tear fluid. Infect Immun. 1997;65:1003–1006
  16. Buranawuti K, Boyle MP, Cheng S, Steiner LL, McDougal K, Fallin MD, et al. Variants in mannose-binding lectin and tumour necrosis factor alpha affect survival in cystic fibrosis. J Med Genet. 2007;44:209–214
  17. Rugh R. Reproductive systems of adult mice. In: The mouse: its reproduction and development. New York: Oxford University Press; 1980;p. 7–43
  18. Ussing HH, Zerahn K. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol Scand. 1951;23:110–127
  19. Rochwerger L, Dho S, Parker L, Foskett JK, Buchwald M. Estrogen-dependent expression of the cystic fibrosis transmembrane regulator gene in a novel uterine epithelial cell line. J Cell Sci. 1994;107:2439–2448
  20. Clemetson CA, Kim JK, Mallikarjuneswara VR, Wilds JH. The sodium and potassium concentrations in the uterine fluid of the rat at the time of implantation. J Endocrinol. 1972;54:417–423
  21. Stutts MJ, Rossier BC, Boucher RC. Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J Biol Chem. 1997;272:14037–14040
  22. Cheung KH, Leung CT, Leung GP, Wong PY. Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. Biol Reprod. 2003;68:1505–1510
  23. Lindsay LA, Murphy CR. Aquaporins are upregulated in glandular epithelium at the time of implantation in the rat. J Mol Histol. 2007;38:87–95
  24. Levi AJ, Segars JH, Miller BT, Leondires MP. Endometrial cavity fluid is associated with poor ovarian response and increased cancellation rates in ART cycles. Hum Reprod. 2001;16:2610–2615
  25. Rochwerger L, Buchwald M. Stimulation of the cystic fibrosis transmembrane regulator expression by estrogen in vivo. Endocrinology. 1993;133:921–930

 Q.H. has nothing to disclose. L.L.T. has nothing to disclose. L.C.A. has nothing to disclose. H.C.C. has nothing to disclose.

 Supported by National 973 projects (2006CB504002); National Science Foundation of China (No. 30900511); Li Ka Shing Institute of Health Sciences and Focused Investments Scheme of The Chinese University of Hong Kong.

 The present address for Dr. Qiong He is Department of Physiology and Pathophysiology, Peking (Beijing) University Health Science Center, Beijing, People's Republic of China.

PII: S0015-0282(10)00100-7

doi: 10.1016/j.fertnstert.2010.01.040

Fertility and Sterility
Volume 93, Issue 8 , Pages 2608-2614 , 15 May 2010

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