Fertility and Sterility
Volume 94, Issue 2 , Pages 754.e1-754.e2, July 2010

Is it the patient or the IVF? Beckwith-Wiedemann syndrome in both spontaneous and assisted reproductive conceptions

  • Estil Y. Strawn Jr., M.D.

      Affiliations

    • Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, Wisconsin
    • Corresponding Author InformationReprint requests: Estil Y. Strawn, Jr., MD, Department of Obstetrics and Gynecology, Director Division of Reproductive Medicine Endocrinology and Infertility, Medical College of Wisconsin, Milwaukee, WI 53226 (FAX: 414-805-6622).
    • ,
  • David Bick, M.D.

      Affiliations

    • Division of Genetics, Department of Pediatrics, Children's Hospital of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Amy Swanson

      Affiliations

    • Department of Clinical Laboratories, University of San Francisco, San Francisco, California

Received 13 April 2009; received in revised form 22 January 2010; accepted 26 January 2010. published online 24 March 2010.

Objective

To describe two children diagnosed with Beckwith-Wiedemann Syndrome (BWS) arising from a spontaneous conception and an assisted reproductive technology (ART) cycle from one patient with a long-standing history of subfertility.

Design

Case report.

Setting

Academic medical center.

Patient(s)

Two children with the morphologic features of BWS as a result of a spontaneous conception and an ART cycle from the same patient.

Intervention(s)

Assisted reproductive technology.

Main Outcome Measure(s)

Neonatal and pediatric morphologic evaluation by geneticists.

Result(s)

Two children with the morphologic features consistent with the criteria for the diagnosis of BWS.

Conclusion(s)

Patients with subfertility may be carriers for genetic disorders that can be passed to a child with or without the use of assisted reproductive technologies (ART). The use of ART may bypass natural selection mechanisms.

Key Words: Beckwith-Wiedemann syndrome, assisted reproductive technology, subfertility

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 E.S. has nothing to disclose. D.B. has nothing to disclose. A.S. has nothing to disclose.

PII: S0015-0282(10)00142-1

doi:10.1016/j.fertnstert.2010.01.067

Fertility and Sterility
Volume 94, Issue 2 , Pages 754.e1-754.e2, July 2010

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