Fertility and Sterility
Volume 94, Issue 6 , Pages 2167-2171 , November 2010

The effectiveness of clomiphene citrate in LH surge suppression in women undergoing IUI: a randomized controlled trial

  • Hesham Al-Inany, M.D., Ph.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt
    • Corresponding Author InformationReprint requests: Hesham Al-Inany, M.D., Ph.D. 8-Moustapha Hassanin St, Manial, Cairo 11451, Egypt.
  • ,
  • Hamdy Azab, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt
  • ,
  • Waleed El-Khayat, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt
  • ,
  • Adel Nada, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt
  • ,
  • Eman El-Khattan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, Cairo University, Cairo, Egypt
  • ,
  • Ahmed M. Abou-Setta, M.D., Ph.D.

      Affiliations

    • Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Alberta, Canada

Received 19 September 2009 ,Revised 24 January 2010 ,Accepted 26 January 2010.

References 

  1. Cohlen BJ. Should we continue performing intrauterine inseminations in the year 2004?. Gynecol Obstet Invest. 2005;59:3–13
  2. Mansour RT, Serour GI, Aboulghar MA. Intrauterine insemination with washed capacitated sperm cells in the treatment of male factor, cervical factor and unexplained infertility. Asia Oceania J Obstet Gynaecol. 1989;15:151–154
  3. Dickey RP, Taylor SN, Lu PY, Sartor BM, Rye PH, Pyrzak R. Effect of diagnosis, age, sperm quality, and number of preovulatory follicles on the outcome of multiple cycles of clomiphene citrate–intrauterine insemination. Fertil Steril. 2002;78:1088–1095
  4. Aboulghar MA, Mansour RT, Serour GI, Al-Inany HG. Diagnosis and management of unexplained infertility: an update. Arch Gynecol Obstet. 2003;267:177–188
  5. Khalil MR, Rasmussen PE, Erb K, Laursen SB, Rex S, Westergaard LG. Homologous intrauterine insemination. An evaluation of prognostic factors based on a review of 2473 cycles. Acta Obstet Gynecol Scand. 2001;80:74–81
  6. Pandian Z, Bhattacharya S, Vale L, Templeton A. In vitro fertilisation for unexplained subfertility. Cochrane Database Syst Rev. 2005;CD003357
  7. Kerin JF, Liu JH, Phillipou G, Yen SS. Evidence for a hypothalamic site of action of clomiphene citrate in women. J Clin Endocrinol Metab. 1985;61:265–268
  8. Cohlen BJ, te Velde ER, van Kooij RJ, Looman CW, Habbema JD. Controlled ovarian hyperstimulation and intrauterine insemination for treating male subfertility: a controlled study. Hum Reprod. 1998;13:1553–1558
  9. Cantineau AE, Cohlen BJ. The prevalence and influence of luteinizing hormone surges in stimulated cycles combined with intrauterine insemination during a prospective cohort study. Fertil Steril. 2007;88:107–112
  10. Allegra A, Marino A, Coffaro F, Scaglione P, Sammartano F, Rizza G, et al. GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial. Hum Reprod. 2007;22:101–108
  11. Letterie GS. Inhibition of gonadotropin surge by a brief mid-cycle regimen of ethinyl estradiol and norethindrone: possible role in in vitro fertilization. Gynecol Endocrinol. 2000;14:1–4
  12. Escudero EL, Boerrigter PJ, Bennink HJ, Epifanio R, Horcajadas JA, Olivennes F, et al. Mifepristone is an effective oral alternative for the prevention of premature luteinizing hormone surges and/or premature luteinization in women undergoing controlled ovarian hyperstimulation for in vitro fertilization. J Clin Endocrinol Metab. 2005;90:2081–2088
  13. Branigan EF, Estes MA. Minimal stimulation IVF using clomiphene citrate and oral contraceptive pill pretreatment for LH suppression. Fertil Steril. 2000;73:587–590
  14. Goverde AJ, McDonnell J, Vermeiden JP, Schats R, Rutten FF, Schoemaker J. Intrauterine insemination or in-vitro fertilisation in idiopathic subfertility and male subfertility: a randomised trial and cost-effectiveness analysis. Lancet. 2000;355:13–18
  15. Matorras R, Diaz T, Corcostegui B, Ramon O, Pijoan JI, Rodriguez-Escudero FJ. Ovarian stimulation in intrauterine insemination with donor sperm: a randomized study comparing clomiphene citrate in fixed protocol versus highly purified urinary FSH. Hum Reprod. 2002;17:2107–2111
  16. Lambalk CB, Leader A, Olivennes F, Fluker MR, Andersen AN, Ingerslev J, et al. Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial. Hum Reprod. 2006;21:632–639
  17. Ragni G, Alagna F, Brigante C, Riccaboni A, Colombo M, Somigliana E, et al. GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a randomized study comparing different gonadotrophin dosages. Hum Reprod. 2004;19:54–58
  18. Manzi DL, Dumez S, Scott LB, Nulsen JC. Selective use of leuprolide acetate in women undergoing superovulation with intrauterine insemination results in significant improvement in pregnancy outcome. Fertil Steril. 1995;63:866–873
  19. Loumaye E. The control of endogenous secretion of LH by gonadotrophin-releasing hormone agonists during ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Hum Reprod. 1990;5:357–376
  20. Nakamura Y, Ono M, Yoshida Y, Sugino N, Ueda K, Kato H. Effects of clomiphene citrate on the endometrial thickness and echogenic pattern of the endometrium. Fertil Steril. 1997;67:256–260

 H.A.-I. has nothing to disclose. H.A. has nothing to disclose. W.E.-K. has nothing to disclose. A.N. has nothing to disclose. E.E.-K. has nothing to disclose. A.A.-S. has nothing to disclose.

PII: S0015-0282(10)00144-5

doi: 10.1016/j.fertnstert.2010.01.069

Fertility and Sterility
Volume 94, Issue 6 , Pages 2167-2171 , November 2010