Fertility and Sterility
Volume 94, Issue 3 , Pages 1097.e9-1097.e12 , August 2010

Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B–producing thecoma and insights into the influence of inhibin B on LH

  • Lois E. Donovan, M.D.

      Affiliations

    • Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    • Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada
    • Corresponding Author InformationReprint requests: Lois E. Donovan, M.D., Foothills Medical Centre, North Tower Room 716, 1403 29th St. NW, Calgary, Alberta, Canada T2N 2T9 (FAX: 403-944-3199).
    • ,
  • Philippa H. Brain, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada
    • ,
  • Máire A. Duggan, M.D.

      Affiliations

    • Department of Obstetrics and Gynecology, University of Calgary, Calgary, Alberta, Canada
    • Department of Pathology and Laboratory Medicine, Foothills Medical Centre, Calgary, Alberta, Canada

Received 22 January 2010 ,Revised 3 February 2010 ,Accepted 4 February 2010.

References 

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  2. Tsigkou A, Luisi S, Reis FM, Petraglia F. Inhibins as diagnostic markers in human reproduction. Adv Clin Chem. 2008;45:1–29
  3. Robertson DM, Hale GE, Jolley D, Fraser IS, Hughes CL, Burger HG. Interrelationships between ovarian and pituitary hormones in ovulatory menstrual cycles across reproductive age. J Clin Endocrinol Metab. 2009;94:138–144
  4. Latronico AC, Anasti J, Arnhold IJ, Rapaport R, Mendonca BB, Bloise W, et al. Brief report: testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene. N Engl J Med. 1996;334:507–512
  5. Berger K, Souza H, Brito VN. d'Alva CB, Mendonca BB, Latronico AC. Clinical and hormonal features of selective follicle-stimulating hormone (FSH) deficiency due to FSH beta-subunit gene mutations in both sexes. Fertil Steril. 2005;83:466–470
  6. Chanson P, Brochier S. Non-functioning pituitary adenomas. J Endocrinol Invest. 2005;28:93–99
  7. Castelo-Branco C, del Pino M, Valladares E. Ovarian hyperstimulation, hyperprolactinaemia and LH gonadotroph adenoma. Reprod Biomed Online. 2009;19:153–155
  8. Knoepfelmacher M, Danilovic DL, Rosa Nasser RH, Mendonca BB. Effectiveness of treating ovarian hyperstimulation syndrome with cabergoline in two patients with gonadotropin-producing pituitary adenomas. Fertil Steril. 2006;86:719;e15–8
  9. Berglund L, Holmberg NG. Heterophilic antibodies against rabbit serum causing falsely elevated gonadotropin levels. Acta Obstet Gynecol Scand. 1989;68:377–378
  10. Cronje HS, Niemand I, Bam RH, Woodruff JD. Review of the granulosa-theca cell tumors from the emil Novak ovarian tumor registry. Am J Obstet Gynecol. 1999;180:323–327
  11. Aboud E. A review of granulosa cell tumours and thecomas of the ovary. Arch Gynecol Obstet. 1997;259:161–165
  12. Outwater EK, Wagner BJ, Mannion C, McLarney JK, Kim B. Sex cord-stromal and steroid cell tumors of the ovary. Radiographics. 1998;18:1523–1546
  13. Lappohn RE, Burger HG, Bouma J, Bangah M, Krans M, de Bruijn HW. Inhibin as a marker for granulosa-cell tumors. N Engl J Med. 1989;321:790–793
  14. Kurihara S, Hirakawa T, Amada S, Ariyoshi K, Nakano H. Inhibin-producing ovarian granulosa cell tumor as a cause of secondary amenorrhea: case report and review of the literature. J Obstet Gynaecol Res. 2004;30:439–443
  15. Meyer AC, Papadimitriou JC, Silverberg SG, Sharara FI. Secondary amenorrhea and infertility caused by an inhibin-B-producing ovarian fibrothecoma. Fertil Steril. 2000;73:258–260
  16. Shaw ND, Srouji SS, Histed SN, McCurnin KE, Hall JE. Aging attenuates the pituitary response to gonadotropin-releasing hormone. J Clin Endocrinol Metab. 2009;94:3259–3264
  17. Lambalk CB, de Boer L, Schoute E, Popp-Snyders C, Schoemaker J. Post-menopausal and chronological age have divergent effects on pituitary and hypothalamic function in episodic gonadotrophin secretion. Clin Endocrinol (Oxf). 1997;46:439–443
  18. Datta M, Winter-Roach BA, Fitzgerald C. Secondary amenorrhoea associated with an isolated elevated serum leuteinising hormone: an unusual presentation of a granulosa cell tumour. J Obstet Gynaecol. 2006;26:830–832
  19. Agha-Hosseini M, Aleyaseen A, Safdarian L, Kashani L. Secondary amenorrhea with low serum luteinizing hormone and follicle-stimulating hormone caused by an inhibin A- and inhibin B-producing granulosa cell tumor. Taiwan J Obstet Gynecol. 2009;48:72–75
  20. Mom CH, Engelen MJ, Willemse PH, Gietema JA, ten Hoor KA, de Vries EG, et al. Granulosa cell tumors of the ovary: the clinical value of serum inhibin A and B levels in a large single center cohort. Gynecol Oncol. 2007;105:365–372

 L.E.D. has nothing to disclose. P.H.B. has nothing to disclose. M.A.D. has nothing to disclose.

PII: S0015-0282(10)00266-9

doi: 10.1016/j.fertnstert.2010.02.016

Fertility and Sterility
Volume 94, Issue 3 , Pages 1097.e9-1097.e12 , August 2010

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