Fertility and Sterility
Volume 94, Issue 3 , Pages 791-794, August 2010

Assessing the reproductive competence of individual embryos: a proposal for the validation of new “-omics” technologies

  • Richard T. Scott Jr., M.D., H.C.L.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey
    • Corresponding Author InformationReprint requests: Richard T. Scott, Jr., M.D., H.C.L.D., 111 Madison Ave, Suite 100, Morristown, New Jersey 07962 (FAX: 973-290-8370).
    • ,
  • Nathan R. Treff, Ph.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey

Received 3 December 2008; received in revised form 22 February 2010; accepted 16 March 2010. published online 11 May 2010.

Rapid technological advances now provide the tools needed to evaluate the molecular genetics, proteomics, and microenvironment of an individual embryo in an effort to predict its reproductive competence. Rigorous criteria for accepting any test as a validated marker of embryonic reproductive competence should be established, and practitioners should be cautious about applying these tests clinically before the availability of comprehensive and convincing evidence.

Key Words: Embryonic reproductive competence, genomics, in vitro fertilization, preimplantation genetic diagnosis, proteomics, transcriptomics

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 R.T.S. has received research grants from EMD Serono, Organon Schering Plough, and Ferring. N.R.T. has nothing to disclose.

PII: S0015-0282(10)00502-9

doi:10.1016/j.fertnstert.2010.03.041

Fertility and Sterility
Volume 94, Issue 3 , Pages 791-794, August 2010

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