Assessing the reproductive competence of individual embryos: a proposal for the validation of new “-omics” technologies
Received 3 December 2008; received in revised form 22 February 2010; accepted 16 March 2010. published online 11 May 2010.
Rapid technological advances now provide the tools needed to evaluate the molecular genetics, proteomics, and microenvironment of an individual embryo in an effort to predict its reproductive competence. Rigorous criteria for accepting any test as a validated marker of embryonic reproductive competence should be established, and practitioners should be cautious about applying these tests clinically before the availability of comprehensive and convincing evidence.
aReproductive Medicine Associates of New Jersey, Morristown, New Jersey
bDivision of Reproductive Endocrinology, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey
Reprint requests: Richard T. Scott, Jr., M.D., H.C.L.D., 111 Madison Ave, Suite 100, Morristown, New Jersey 07962 (FAX: 973-290-8370).
R.T.S. has received research grants from EMD Serono, Organon Schering Plough, and Ferring. N.R.T. has nothing to disclose.
ABSTRACT