Fertility and Sterility
Volume 94, Issue 3 , Pages 791-794 , August 2010

Assessing the reproductive competence of individual embryos: a proposal for the validation of new “-omics” technologies

  • Richard T. Scott Jr., M.D., H.C.L.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey
    • Corresponding Author InformationReprint requests: Richard T. Scott, Jr., M.D., H.C.L.D., 111 Madison Ave, Suite 100, Morristown, New Jersey 07962 (FAX: 973-290-8370).
    • ,
  • Nathan R. Treff, Ph.D.

      Affiliations

    • Reproductive Medicine Associates of New Jersey, Morristown, New Jersey
    • Division of Reproductive Endocrinology, Department of Obstetrics Gynecology and Reproductive Science, University of Medicine and Dentistry of New Jersey–Robert Wood Johnson Medical School, New Brunswick, New Jersey

Received 3 December 2008 ,Revised 22 February 2010 ,Accepted 16 March 2010.

References 

  1. Adamson D, Baker V. Multiple births from assisted reproductive technologies: a challenge that must be met. Fertil Steril. 2004;81:517–522
  2. Van Montfoort AP, Fiddelers AA, Janssen JM, Derhaag JG, Dirksen CD, Dunselman GA, et al. In unselected patients, elective single embryo transfer prevents all multiples, but results in significantly lower pregnancy rates compared with double embryo transfer: a randomized controlled trial. Hum Reprod. 2006;21:338–343
  3. Handyside AH, Pattinson JK, Penketh RJ, Delhanty JD, Winston RM, Tuddenham EG. Biopsy of human preimplantation embryos and sexing by DNA amplification. Lancet. 1989;1:347–349
  4. Mastenbroek S, Twisk M, van Echten-Arends J, Sikkema-Raddatz B, Korevaar JC, Verhoeve HR, et al. In vitro fertilization with preimplantation genetic screening. New Engl J Med. 2007;357:9–17
  5. Treff NR, Su J, Tao X, Levy B, Scott RT Jr. Accurate single cell 24 chromosomeaneuploidy screening using whole genome amplification and single nucleotide polymorphism microarrays. Fertil Steril. Published online February 24, 2010.
  6. Katz-Jaffe M, McCallie BR, Treff NR, Miller KA, Scott RT, Schoolcraft WB. A novel profile of cumulus cell transcripts is associated with oocyte aneuploidy. Fertil Steril. 2008;90(Suppl 1):S36
  7. Brison DR, Houghton FD, Falconer D, Roberts SA, Hawkhead J, Humpherson PG, et al. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod. 2004;19:2319–2324
  8. Scott R, Seli E, Miller K, Sakkas D, Scott K, Burns DH. Noninvasive metabolomic profiling of human embryo culture media using Raman spectroscopy predicts embryonic reproductive potential: a prospective blinded pilot study. Fertil Steril. 2008;90:77–83
  9. Scott RT, Miller KA, Olivares R, Su J, Fratterelli J, Treff NR. Microarray based 24 chromosome preimplantation genetic diagnosis (mPGD) is highly predictive of the reproductive potential of human embryos:a prospective blinded non-selection trial. Fertil Steril. 2008;90(Suppl 1):S22–S23
  10. Spits C, Sermon K. PGD for monogenic disorders: aspects of molecular biology. Prenat Diag. 2009;29:50–56
  11. Henry NL, Hayes DF. Uses and abuses of tumor markers in the diagnosis, monitoring, and treatment of primary and metastatic breast cancer. Oncologist. 2006;11:541–552
  12. Jennings L, Van Deerlin VM, Gulley ML. Recommended principles and practices for validating clinical molecular pathology tests. College of American Pathologists Molecular Pathology Resource Committee. Arch Pathol Lab Med. 2009;133:743–755
  13. Pepe MS, Etzioni R, Feng Z, Potter JD, Thompson ML, Thornquist M, et al. Phases of biomarker development for early detection of cancer. J Natl Cancer Inst. 2001;93:1054–1061

 R.T.S. has received research grants from EMD Serono, Organon Schering Plough, and Ferring. N.R.T. has nothing to disclose.

PII: S0015-0282(10)00502-9

doi: 10.1016/j.fertnstert.2010.03.041

Fertility and Sterility
Volume 94, Issue 3 , Pages 791-794 , August 2010

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