Fertility and Sterility
Volume 95, Issue 1 , Pages 152-157 , January 2011

A randomized trial of the effect of testosterone and estrogen on verbal fluency, verbal memory, and spatial ability in healthy postmenopausal women

  • Ljiljana Kocoska-Maras, M.D.

      Affiliations

    • Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Niklas Zethraeus, Ph.D.

      Affiliations

    • Department of Economics, Stockholm School of Economics, Stockholm, Sweden
    • Medical Management Centre, Institution for Learning, Informatics, Management and Ethics, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Angelique Flöter Rådestad, M.D., Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Tore Ellingsen, Ph.D.

      Affiliations

    • Department of Economics, Stockholm School of Economics, Stockholm, Sweden
  • ,
  • Bo von Schoultz, M.D., Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
  • ,
  • Magnus Johannesson, Ph.D.

      Affiliations

    • Department of Economics, Stockholm School of Economics, Stockholm, Sweden
  • ,
  • Angelica Lindén Hirschberg, M.D., Ph.D.

      Affiliations

    • Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden
    • Corresponding Author InformationReprint requests: Angelica Lindén Hirschberg, M.D., Ph.D., Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, SE-171 76 Stockholm, Sweden (FAX: 46-8-5177-4252).

Received 7 April 2010 ,Revised 26 May 2010 ,Accepted 27 May 2010.

  • Image Result

    The design of the double-blind randomized trial.

    The design of the double-blind randomized trial.

  • Image Result

    Mean values of verbal fluency, verbal memory, and spatial ability after 4 weeks of treatments with testosterone (T), estrogen (E), and placebo (P). Error bars indicate 95% confidence intervals. There

    Mean values of verbal fluency, verbal memory, and spatial ability after 4 weeks of treatments with testosterone (T), estrogen (E), and placebo (P). Error bars indicate 95% confidence intervals. There were no significant differences between any of the treatment groups (ANOVA/ANCOVA, P>0.05).

 Supported by the Swedish Research Council (No. 20324), Karolinska Institutet, Jan Wallander and Tom Hedelius Foundation, and the Swedish Council for Working Life and Social Research.

 L. K-M. has nothing to disclose. N.Z. has nothing to disclose. A.F.R. has nothing to disclose. T.E. has nothing to disclose. B.v.S. has nothing to disclose. M.J. has nothing to disclose. A.L.H. has nothing to disclose.

PII: S0015-0282(10)00943-X

doi: 10.1016/j.fertnstert.2010.05.062

Fertility and Sterility
Volume 95, Issue 1 , Pages 152-157 , January 2011