Fertility and Sterility
Volume 94, Issue 7 , Pages 2772-2775, December 2010

Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure

  • Anne Bachelot, M.D., Ph.D.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Pierre et Marie Curie, Paris, France
    • Département d'Endocrinologie et Médecine de la Reproduction, Centre de référence des Maladies Endocriniennes rares de la croissance, Assistance Publique–Hôpitaux de Paris, Paris, France
    • ,
  • Justine Bouilly, B.Sc.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Paris Descartes, Faculté de Médecine, Paris, France
    • ,
  • Yuchen Liu, B.Sc.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Paris Descartes, Faculté de Médecine, Paris, France
    • ,
  • Diane Rebourcet, Ph.D.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Paris Descartes, Faculté de Médecine, Paris, France
    • ,
  • Céline Leux, B.Sc.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Paris Descartes, Faculté de Médecine, Paris, France
    • ,
  • Frédérique Kuttenn, M.D.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Pierre et Marie Curie, Paris, France
    • Département d'Endocrinologie et Médecine de la Reproduction, Centre de référence des Maladies Endocriniennes rares de la croissance, Assistance Publique–Hôpitaux de Paris, Paris, France
    • ,
  • Philippe Touraine, M.D., Ph.D.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Pierre et Marie Curie, Paris, France
    • Département d'Endocrinologie et Médecine de la Reproduction, Centre de référence des Maladies Endocriniennes rares de la croissance, Assistance Publique–Hôpitaux de Paris, Paris, France
    • ,
  • Nadine Binart, Ph.D.

      Affiliations

    • Institut National de la Santé et de la Recherche Médicale, U845, Paris, France
    • Université Paris Descartes, Faculté de Médecine, Paris, France
    • Corresponding Author InformationReprint requests: Nadine Binart, Ph.D., INSERM, U845, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, France (FAX: 331-40-61-55-87).

Received 25 March 2010; received in revised form 12 May 2010; accepted 15 June 2010. published online 26 July 2010.

Using a mouse model expressing only the PRL receptor short isoform mimicking premature ovarian failure, signaling pathways induced by PRL were analyzed in mouse ovaries. Sequencing of the coding portion of exons 10 and 11, specific to the long and short receptor isoform, respectively, did not revealed any mutation in 101 women with premature ovarian failure.

Key Words: Prolactin receptor, short form, premature ovarian failure, PI3 kinase

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

 A.B. has nothing to disclose. J.B. has nothing to disclose. Y.L. has nothing to disclose. D.R. has nothing to disclose. C.L. has nothing to disclose. F.K. has nothing to disclose. P.T. has nothing to disclose. N.B. has nothing to disclose.

 This work was supported by Institut National de la Santé et de la Recherche Médicale. N.B. was awarded an Institut National de la Santé et de la Recherche Médicale–Assistance Publique–Hôpitaux de Paris Interface contract.

PII: S0015-0282(10)00993-3

doi:10.1016/j.fertnstert.2010.06.040

Fertility and Sterility
Volume 94, Issue 7 , Pages 2772-2775, December 2010

Article Tools

* Image Usage & Resolution