Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure

Received 25 March 2010; received in revised form 12 May 2010; accepted 15 June 2010. published online 26 July 2010.
Corrected Proof

Using a mouse model expressing only the PRL receptor short isoform mimicking premature ovarian failure, signaling pathways induced by PRL were analyzed in mouse ovaries. Sequencing of the coding portion of exons 10 and 11, specific to the long and short receptor isoform, respectively, did not revealed any mutation in 101 women with premature ovarian failure.

Key Words: Prolactin receptor, short form, premature ovarian failure, PI3 kinase

a Institut National de la Santé et de la Recherche Médicale, U845, Paris, France

b Université Pierre et Marie Curie, Paris, France

c Département d'Endocrinologie et Médecine de la Reproduction, Centre de référence des Maladies Endocriniennes rares de la croissance, Assistance Publique–Hôpitaux de Paris, Paris, France

d Université Paris Descartes, Faculté de Médecine, Paris, France

Reprint requests: Nadine Binart, Ph.D., INSERM, U845, Faculté de Médecine Necker, 156 rue de Vaugirard, 75015 Paris, France (FAX: 331-40-61-55-87).

A.B. has nothing to disclose. J.B. has nothing to disclose. Y.L. has nothing to disclose. D.R. has nothing to disclose. C.L. has nothing to disclose. F.K. has nothing to disclose. P.T. has nothing to disclose. N.B. has nothing to disclose.

This work was supported by Institut National de la Santé et de la Recherche Médicale. N.B. was awarded an Institut National de la Santé et de la Recherche Médicale–Assistance Publique–Hôpitaux de Paris Interface contract.

PII: S0015-0282(10)00993-3

doi:10.1016/j.fertnstert.2010.06.040