Fertility and Sterility
Volume 94, Issue 7 , Pages 2835-2837, December 2010

Age at onset of multiple sclerosis is correlated to use of combined oral contraceptives and childbirth before diagnosis

  • Per Holmqvist, M.D.

      Affiliations

    • Division of Womens and Childrens Health, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
    • Clinical Department of Obstetrics and Gynecology, County Hospital Sundsvall, Sweden
    • Corresponding Author InformationReprint requests: Per Holmqvist, M.D., Clinical Department of Obstetrics and Gynecology, County Hospital, SE-85186 Sundsvall, Sweden (FAX: 46-60-181557).
    • ,
  • Mats Hammar, M.D., Ph.D.

      Affiliations

    • Division of Womens and Childrens Health, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
    • ,
  • Anne-Marie Landtblom, M.D., Ph.D.

      Affiliations

    • Division of Neurology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden
    • ,
  • Jan Brynhildsen, M.D., Ph.D.

      Affiliations

    • Division of Womens and Childrens Health, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden

Received 9 February 2010; received in revised form 3 June 2010; accepted 16 June 2010. published online 31 August 2010.

The aim of this study was to evaluate whether age of onset of multiple sclerosis is related to use of combined oral contraceptives and/or timing of childbirth. The results showed that use of combined oral contraceptives and childbirth before the first multiple sclerosis symptom was correlated to a higher mean age at the onset of the disease.

Key Words: Multiple sclerosis, estrogen, combined oral contraceptives

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 P.H. has nothing to disclose. M.H. has nothing to disclose. A-M.L. has nothing to disclose. J.B. has nothing to disclose.

PII: S0015-0282(10)00998-2

doi:10.1016/j.fertnstert.2010.06.045

Fertility and Sterility
Volume 94, Issue 7 , Pages 2835-2837, December 2010

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