Aneuploidies in embryos and spermatozoa from patients with Y chromosome microdeletions
Received 11 February 2010; received in revised form 8 June 2010; accepted 16 June 2010. published online 26 July 2010. Corrected Proof
In patients with Y chromosome microdeletions and high percentage of numeric chromosome abnormalities detected by fluorescence in situ hybridization on sperm, a high percentage of abnormal embryos was observed compared with oligozoospermic patients without Y chromosome microdeletions, with a significant increase in the percentage of embryos with monosomy X. Differences in fertilization rates between the different patient groups were not observed; however, blastocyst rates were significantly impaired in patients with Y chromosome microdeletions.
aInstituto Valenciano de Infertilidad, Valencia, Spain
bInstituto Valenciano de Infertilidad, Murcia, Spain
Reprint requests: Emilia Mateu, Ph.D., Instituto Universitario IVI, Pl. Policia Local 3, 46015 Valencia, Spain (FAX: 34-963-05-09-99).
E.M. has nothing to disclose. L.R. has nothing to disclose. M.C.M. has nothing to disclose. V.P. has nothing to disclose. M.M. has nothing to disclose. M.G-S. has nothing to disclose. J.M.M-J. has nothing to disclose. J.R. has nothing to disclose. A.P. has nothing to disclose. C.R. has nothing to disclose.
ABSTRACT