Fertility and Sterility
Volume 94, Issue 7 , Pages 2874-2877, December 2010

Aneuploidies in embryos and spermatozoa from patients with Y chromosome microdeletions

  • Emilia Mateu, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • Corresponding Author InformationReprint requests: Emilia Mateu, Ph.D., Instituto Universitario IVI, Pl. Policia Local 3, 46015 Valencia, Spain (FAX: 34-963-05-09-99).
    • ,
  • Lorena Rodrigo, B.Sc.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • M. Carmen Martínez, B.Sc.

      Affiliations

    • Instituto Valenciano de Infertilidad, Murcia, Spain
    • ,
  • Vanessa Peinado, B.Sc.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • Miguel Milán, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • Manuel Gil-Salom, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • Jose Maria Martínez-Jabaloyas, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • José Remohí, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • Antonio Pellicer, M.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain
    • ,
  • Carmen Rubio, Ph.D.

      Affiliations

    • Instituto Valenciano de Infertilidad, Valencia, Spain

Received 11 February 2010; received in revised form 8 June 2010; accepted 16 June 2010. published online 26 July 2010.

In patients with Y chromosome microdeletions and high percentage of numeric chromosome abnormalities detected by fluorescence in situ hybridization on sperm, a high percentage of abnormal embryos was observed compared with oligozoospermic patients without Y chromosome microdeletions, with a significant increase in the percentage of embryos with monosomy X. Differences in fertilization rates between the different patient groups were not observed; however, blastocyst rates were significantly impaired in patients with Y chromosome microdeletions.

Key Words: Y microdeletion, aneuploidy, sperm, embryo

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 E.M. has nothing to disclose. L.R. has nothing to disclose. M.C.M. has nothing to disclose. V.P. has nothing to disclose. M.M. has nothing to disclose. M.G-S. has nothing to disclose. J.M.M-J. has nothing to disclose. J.R. has nothing to disclose. A.P. has nothing to disclose. C.R. has nothing to disclose.

PII: S0015-0282(10)00999-4

doi:10.1016/j.fertnstert.2010.06.046

Fertility and Sterility
Volume 94, Issue 7 , Pages 2874-2877, December 2010

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